ID A0A1V6YKK1_PENNA Unreviewed; 321 AA.
AC A0A1V6YKK1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PENNAL_c0018G01385 {ECO:0000313|EMBL:OQE87970.1};
OS Penicillium nalgiovense.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=60175 {ECO:0000313|EMBL:OQE87970.1, ECO:0000313|Proteomes:UP000191691};
RN [1] {ECO:0000313|Proteomes:UP000191691}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 13039 {ECO:0000313|Proteomes:UP000191691};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE87970.1}.
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DR EMBL; MOOB01000018; OQE87970.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6YKK1; -.
DR STRING; 60175.A0A1V6YKK1; -.
DR OMA; CSEAFDM; -.
DR OrthoDB; 203032at2759; -.
DR Proteomes; UP000191691; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR22981:SF81; DEHYDROGENASE, PUTATIVE-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000191691}.
FT DOMAIN 7..175
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 181..303
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 185
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 321 AA; 34535 MW; 3D6A81AA2A82543D CRC64;
MMQAKAIGFI GLGNMGFSMV VNLAEKLPVN SSVHVFDIIP ALVDDICAKY PDRVVACSGP
KDVADRSDII ITMLPEGKHV KAVYMEPDGI CSSDVGQKLL VDCSTIDTAS FLEIKDHISK
NFPRASFYDA PVSGGVIGAE RGMIAFFLGC AEDNIKDIEE LGQLFSLMGN KLIPCGGPSL
GIAAKLSNNY LSGIIAIACS EAMDMGMKSG LDPRVLAQVY AAGNAQNTIC DRFNPVPGVD
PDAPSSNGYK KGFKVHLMKK DISLALDMAR RVGSTNVLGS VGLQIYKEAS EDERCKDLDS
RIVFRYLGGN EDWKADHENK K
//
