ID A0A1V6YS80_PENNA Unreviewed; 395 AA.
AC A0A1V6YS80;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Steroid 5-alpha reductase C-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PENNAL_c0012G09730 {ECO:0000313|EMBL:OQE90309.1},
GN PNAL_LOCUS9739 {ECO:0000313|EMBL:CAG8295972.1};
OS Penicillium nalgiovense.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=60175 {ECO:0000313|EMBL:OQE90309.1, ECO:0000313|Proteomes:UP000191691};
RN [1] {ECO:0000313|EMBL:OQE90309.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 13039 {ECO:0000313|EMBL:OQE90309.1};
RA Nielsen J.C., Nielsen J.;
RT "Uncovering the secondary metabolism of Penicillium species provides
RT insights into the evolution of 6-MSA pathways.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000191691}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 13039 {ECO:0000313|Proteomes:UP000191691};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
RN [3] {ECO:0000313|EMBL:CAG8295972.1}
RP NUCLEOTIDE SEQUENCE.
RA Branca A.L. A.;
RL Submitted (JUL-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE90309.1}.
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DR EMBL; CAJVNV010000625; CAG8295972.1; -; Genomic_DNA.
DR EMBL; MOOB01000012; OQE90309.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6YS80; -.
DR OMA; WRKGGYQ; -.
DR OrthoDB; 1420758at2759; -.
DR Proteomes; UP000191691; Unassembled WGS sequence.
DR Proteomes; UP001153461; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.1630; -; 1.
DR InterPro; IPR010721; UstE-like.
DR PANTHER; PTHR32251; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 1.
DR PANTHER; PTHR32251:SF35; DUF1295 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G02670); 1.
DR Pfam; PF06966; DUF1295; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000191691};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 395 AA; 45009 MW; EF5A787017F93E1F CRC64;
MYFLFRHTIP NQAITGQLTR PTPPEQTNGF CFPFLCGILI LYSAAMASLP LPRVESLLDY
TSFELTVLPY LTQLQWLPDS LREAGSDVHS LRAVYLATNP LVSAIAFSGV LAGLLFIAAE
INRNYSQIDR FWSILPALYN VHFALWARLS GIQTQTLDTI AVVTVLWSIR LTYNYWRKGG
YSIGSEDYRW EVVRSKVNNS FVFMIFNLGF ISIAQSLLLL LITTPTYIFV VAAYNQGPET
FGLPDLAFSR AAFFFIIIEF FADGQQWKFQ SAKKEYQTNA RIPEPYKDQF SAEDLERGFV
VSGLWSWSRH PNFVAEQAFW LTMYLWSCYR TETYFNWTGL GALGTIAIFQ GSVRLTEAIT
AGKYPEYSDY QARVGRFIPR LSVKAKKTKA SKKST
//
