ID A0A1V6YSL1_PENNA Unreviewed; 638 AA.
AC A0A1V6YSL1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=histone deacetylase {ECO:0000256|ARBA:ARBA00012111};
DE EC=3.5.1.98 {ECO:0000256|ARBA:ARBA00012111};
GN ORFNames=PENNAL_c0012G06757 {ECO:0000313|EMBL:OQE90288.1},
GN PNAL_LOCUS9650 {ECO:0000313|EMBL:CAG8292083.1};
OS Penicillium nalgiovense.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=60175 {ECO:0000313|EMBL:OQE90288.1, ECO:0000313|Proteomes:UP000191691};
RN [1] {ECO:0000313|EMBL:OQE90288.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 13039 {ECO:0000313|EMBL:OQE90288.1};
RA Nielsen J.C., Nielsen J.;
RT "Uncovering the secondary metabolism of Penicillium species provides
RT insights into the evolution of 6-MSA pathways.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000191691}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 13039 {ECO:0000313|Proteomes:UP000191691};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
RN [3] {ECO:0000313|EMBL:CAG8292083.1}
RP NUCLEOTIDE SEQUENCE.
RA Branca A.L. A.;
RL Submitted (JUL-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the histone deacetylase family. HD type 1
CC subfamily. {ECO:0000256|ARBA:ARBA00006457}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE90288.1}.
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DR EMBL; CAJVNV010000624; CAG8292083.1; -; Genomic_DNA.
DR EMBL; MOOB01000012; OQE90288.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6YSL1; -.
DR STRING; 60175.A0A1V6YSL1; -.
DR OMA; EHRWDKH; -.
DR OrthoDB; 1327607at2759; -.
DR Proteomes; UP000191691; Unassembled WGS sequence.
DR Proteomes; UP001153461; Unassembled WGS sequence.
DR GO; GO:1902494; C:catalytic complex; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0004407; F:histone deacetylase activity; IEA:UniProtKB-EC.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR CDD; cd10004; RPD3-like; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR003084; His_deacetylse_1.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF13; HISTONE DEACETYLASE HDAC1; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR PRINTS; PR01271; HISDACETLASE.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000191691}.
FT DOMAIN 35..324
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT REGION 390..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 70862 MW; D61A8120A20FE6EC CRC64;
MALEPISDRL LGSKNKKVAY FYDSDVGNYA YVSGHPMKPH RIRMTHSLVM NYGLYKKMEI
YRAKPASKYE MTQFHTDEYI DFLSKVTPDN MDHFSKEQSR YNVGDDCPVF DGLFEFCGIS
AGGSMEGAAR LNRNKCDVAV NWAGGLHHAK KSEASGFCYV NDIVLGILEL LRFKQRVLYV
DIDVHHGDGV EEAFYTTDRV MTCSFHKYGE YFPGTGELRD IGVGQGKNYA VNFPLRDGIT
DETYKSIFEP VIKSVMEWYR PEAVVLQCGG DSLSGDRLGC FNLSMRGHAN CVNFVKSFDL
PTLVLGGGGY TMRNVARTWA YETGILVGEP LGSELPYNDY YEYFAPDYQL DVRPSNMDNA
NTKEYLDKIR NQVVENLKRT AFAPSVQMTD VPRNPILDGM DDEADDVMDD LDEDENKDKR
FTQRRFDQRT EKAGELSDSE DEDENAANGV RRQPGGMRRR NQVNYRNLEP DSGLDSGMAT
PQDGSSAADG EMDFALDANA PRTEPEAPFA GPEASHADET PMTDADNMAM ESEEQEAPTA
SQHQSPRPHD EDTTMEDVAA VAEPTTSEQA PAKAPSIEEK SLVEGSAASP VRAQSPPKEA
ADSTLEKSAE ASAPTADTEA TATKEENLEP MAETKKEE
//
