ID A0A1V6YZ46_PENNA Unreviewed; 548 AA.
AC A0A1V6YZ46;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=PABS domain-containing protein {ECO:0000259|PROSITE:PS51006};
GN ORFNames=PENNAL_c0007G09165 {ECO:0000313|EMBL:OQE92462.1},
GN PNAL_LOCUS9084 {ECO:0000313|EMBL:CAG8266969.1};
OS Penicillium nalgiovense.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=60175 {ECO:0000313|EMBL:OQE92462.1, ECO:0000313|Proteomes:UP000191691};
RN [1] {ECO:0000313|EMBL:OQE92462.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 13039 {ECO:0000313|EMBL:OQE92462.1};
RA Nielsen J.C., Nielsen J.;
RT "Uncovering the secondary metabolism of Penicillium species provides
RT insights into the evolution of 6-MSA pathways.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000191691}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 13039 {ECO:0000313|Proteomes:UP000191691};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
RN [3] {ECO:0000313|EMBL:CAG8266969.1}
RP NUCLEOTIDE SEQUENCE.
RA Branca A.L. A.;
RL Submitted (JUL-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the spermidine/spermine synthase family.
CC {ECO:0000256|ARBA:ARBA00007867}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE92462.1}.
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DR EMBL; CAJVNV010000614; CAG8266969.1; -; Genomic_DNA.
DR EMBL; MOOB01000007; OQE92462.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6YZ46; -.
DR STRING; 60175.A0A1V6YZ46; -.
DR OMA; CFIGWAG; -.
DR OrthoDB; 5489391at2759; -.
DR Proteomes; UP000191691; Unassembled WGS sequence.
DR Proteomes; UP001153461; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR030374; PABS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF037959; MFS_SpdSyn; 1.
DR Pfam; PF01564; Spermine_synth; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51006; PABS_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Polyamine biosynthesis {ECO:0000256|PROSITE-ProRule:PRU00354};
KW Reference proteome {ECO:0000313|Proteomes:UP000191691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00354}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 309..464
FT /note="PABS"
FT /evidence="ECO:0000259|PROSITE:PS51006"
FT ACT_SITE 383
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00354"
SQ SEQUENCE 548 AA; 60879 MW; E6EF370599340C88 CRC64;
MSLQDMLQHI DARRFTTGVV LLILLAFYSP LSKLVLSPTY GSYAAHIFHS FGVTISGGVG
WLLKDKILKR LGRLGGFMLP VLAFWVPTLQ YFIKQQSSKI GNPTGPVITE LCGYYPLVLL
TVAYAGKQIQ TSLRLEAQGD LIVEHVPLIG TYVFYSAGEH IAHFVLSWIV GTSVFFTRVG
MQMLLAACYS ALIPSKWLVL AIPSIIFSVT SNVHFAGISG VNSAIEHEGY SLLARQEAYT
GYISVLENEN DGFRVMRCDH SLLGGQWTRL APGYRPEVED PIYAIFAMLE AVRLVEPDHG
VPRVDADSKA LVIGLGIGTT PSALIKHGIE TTIVEIDPVV HKFATQYFNL PPNHIPVIED
AVKFVKKAES SPNKPQYDFI VHDVFTGGAE PAELFTYEFL SGLHSLLKED GAIAINYAGD
LTLYPTGLIV RTIAAVFPSC RIFREAPSGE DEDTDFTNMV LFCKKSSNTP VQFRDPVPAD
FLRSRSRESY LVPKHELDAA MFSTWPKGGR SLLWAKEVGR LHKFQDRSAL KHWAIMRKVL
PDAVWENW
//
