ID A0A1V6Z0B2_PENNA Unreviewed; 1576 AA.
AC A0A1V6Z0B2;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 08-NOV-2023, entry version 24.
DE RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
GN ORFNames=PENNAL_c0006G04843 {ECO:0000313|EMBL:OQE93067.1};
OS Penicillium nalgiovense.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=60175 {ECO:0000313|EMBL:OQE93067.1, ECO:0000313|Proteomes:UP000191691};
RN [1] {ECO:0000313|Proteomes:UP000191691}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 13039 {ECO:0000313|Proteomes:UP000191691};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE93067.1}.
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DR EMBL; MOOB01000006; OQE93067.1; -; Genomic_DNA.
DR STRING; 60175.A0A1V6Z0B2; -.
DR OMA; ATRFLMN; -.
DR OrthoDB; 20915at2759; -.
DR Proteomes; UP000191691; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR018515; Tuberin-type_domain.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR InterPro; IPR024584; Tuberin_N.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR Pfam; PF11864; DUF3384; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF03542; Tuberin; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000191691}.
FT DOMAIN 1278..1515
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 30..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1513..1534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1576 AA; 174549 MW; 0E75993043B0235E CRC64;
MSSDDVPQFS QHKPSSTSFA DVFKTLGVGR PKSHSPVSLQ ESSSDSLSHT DSRGTNRRAH
GYESMHRGSV VSSSSDTPSG LDFETSLHNL SQRQNLAHAI EEADGLSKGL SWFSSDLSVV
LWEAAEYLLH HESSPDAQQS GARLLEAIAT RQDLSPSARR LVFESIASPT EPEVIAARVQ
SLISLSDHGR KLDFASSSIL HIISSWIVPF YETIASARAK AKKGKMVKPH GPSHDEAVFA
DLFQFVVDLI TLQRKQPTQE EIETLLTEIF TICRRTSVAA DIKNSLAVFD AVIMYADVPD
ISFPTLLEVL CSIHASVKPL SGPTSRAVRS LAKSRRQAEM VNTLHDFLRN SCAVEQSRNL
NVLRGTIYVF SDFVRAYGQD GMPQLPFDQL MESLQVIAQK DDSRVDADML DLCLNILEGD
YVRVALERDW TAFVNLLILC SRRLVDESAP SPTSTTNPQG KPTYDETKSY ILANLIRIAS
ALESPWEQLN GEQKQHAVRF LMKIHQHVEP PQAELIIHSM REDKICHPSN NSNWAQHCRE
LVECFVQPRK QSSDIRILAL DTLKEALSGH EDLLFSHKHG LLGLLLKDFS AEHDLLFLES
LVSLLTGPAI KYSDDDMFKL LISTIGAPMQ AELHRDEPRE HPPSHGTQRR TSTTSVLELS
LTNVCAVGLV KMMLRALNLS STKAVMIFEA LLDIAQSPSR PVDSRLTVLK LLFRLRCDSA
GSVTVISTSE SDFLMNVLGR NLDGGSKLQA PSDSPTREIP QQDNSPVSPT GKLPTKESAS
TPMSKSAQGR GSISARGSKL TAPVWTYALP QVLPEQPSGE SSPVVFAYTH PEESKPAESE
TTITRTTGLL KVKMWLEVVI TLLQREVDWD VYSYILTHIG PQLGNKDFFR DAIPQITLLR
SILCDQVKNG TFHEPPETTG LKKSDVAACI FDALCMLVSY HEHFAKSEED DLVRAFMQGI
IGSWGGTSRG CIQALSLCCY EIPMSVTKSL NSILDRMSKV ITMSNIAVHI LELLALLARL
PAVYVNLREE EIRTVFGICI RFLQTSREHR YKASELAARA SLSAQPTQSR LSAGAKEIAA
HAAEAVETSQ DGMSKYISNL TYHVMVFWFL SLKLQDRPKH VNWITSRLIY HDEHGKEVVE
EQSQVFIDLM QRVAYSDLGE TIPFETFPPS PEDGPVAKKS WIVGMSIVTV ESAGLSGLSQ
ITKRQASGTT YSVYQQRTAP VLPHQVPPTP DAHLHSDSMR TAVLPSHIML QLTATAFPTP
TVMQPIPVPE DDITRRAISN FDRTDIVDGH RIGVVYIDDG QTKEADILAN TGGSADYENL
LSGLGIKVSL RNPQFNPQGL YADTDGEYTY AWRDRVTEIV YHVATMMPTD FDRDPACVNK
KRNLGNNHVT IVFNRSNLPF NFDTIPSEFN SINIVITPSS RIAYDESGNA SGETDPQKLY
YSVQVMSKPG FPDVSPAATP KVISGKNLAP FVRILALNAS VFSLVWSNKG GEHTSSWTTR
LREIKKVRER ALKAQSEGSE AAEGTYPGLR RNTKPNIFSE ELPSRAPQVQ TDFAAEWNAA
ADTNILQNLD FSRWAR
//
