ID A0A1V6Z3W9_PENNA Unreviewed; 1526 AA.
AC A0A1V6Z3W9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Flavodoxin-like domain-containing protein {ECO:0000259|PROSITE:PS50902};
GN ORFNames=PENNAL_c0004G07955 {ECO:0000313|EMBL:OQE94375.1},
GN PNAL_LOCUS415 {ECO:0000313|EMBL:CAG7948352.1};
OS Penicillium nalgiovense.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=60175 {ECO:0000313|EMBL:OQE94375.1, ECO:0000313|Proteomes:UP000191691};
RN [1] {ECO:0000313|EMBL:OQE94375.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 13039 {ECO:0000313|EMBL:OQE94375.1};
RA Nielsen J.C., Nielsen J.;
RT "Uncovering the secondary metabolism of Penicillium species provides
RT insights into the evolution of 6-MSA pathways.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000191691}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 13039 {ECO:0000313|Proteomes:UP000191691};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
RN [3] {ECO:0000313|EMBL:CAG7948352.1}
RP NUCLEOTIDE SEQUENCE.
RA Branca A.L. A.;
RL Submitted (JUL-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- COFACTOR:
CC Name=siroheme; Xref=ChEBI:CHEBI:60052;
CC Evidence={ECO:0000256|ARBA:ARBA00001929};
CC -!- SIMILARITY: Belongs to the nitrite and sulfite reductase 4Fe-4S domain
CC family. {ECO:0000256|ARBA:ARBA00010429}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE94375.1}.
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DR EMBL; CAJVNV010000011; CAG7948352.1; -; Genomic_DNA.
DR EMBL; MOOB01000004; OQE94375.1; -; Genomic_DNA.
DR STRING; 60175.A0A1V6Z3W9; -.
DR OMA; YGSYTQV; -.
DR OrthoDB; 5474937at2759; -.
DR Proteomes; UP000191691; Unassembled WGS sequence.
DR Proteomes; UP001153461; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.30.413.10; Sulfite Reductase Hemoprotein, domain 1; 2.
DR Gene3D; 3.90.480.10; Sulfite Reductase Hemoprotein;Domain 2; 1.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR005117; NiRdtase/SiRdtase_haem-b_fer.
DR InterPro; IPR036136; Nit/Sulf_reduc_fer-like_dom_sf.
DR InterPro; IPR006067; NO2/SO3_Rdtase_4Fe4S_dom.
DR InterPro; IPR045169; NO2/SO3_Rdtase_4Fe4S_prot.
DR InterPro; IPR045854; NO2/SO3_Rdtase_4Fe4S_sf.
DR InterPro; IPR006066; NO2/SO3_Rdtase_FeS/sirohaem_BS.
DR InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR PANTHER; PTHR11493:SF47; SULFITE REDUCTASE [NADPH] SUBUNIT BETA; 1.
DR PANTHER; PTHR11493; SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF01077; NIR_SIR; 1.
DR Pfam; PF03460; NIR_SIR_ferr; 2.
DR Pfam; PF01855; POR_N; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR PRINTS; PR00397; SIROHAEM.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF56014; Nitrite and sulphite reductase 4Fe-4S domain-like; 2.
DR SUPFAM; SSF55124; Nitrite/Sulfite reductase N-terminal domain-like; 2.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
DR PROSITE; PS00365; NIR_SIR; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000191691}.
FT DOMAIN 782..931
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT REGION 213..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1526 AA; 168253 MW; 771AE469478909C7 CRC64;
MVSISSAAEA VARIAYLTSD TVLSVQPSLQ NDSLFSKSLK ALKSNKTSNL SSKVTEVQAV
RYNEDPLLSV FTPLQNGETT SIVTSSSVLI TAVPHLYRLA NSPVVIHVAL EPSPFPDYSV
ISSIRQSGFT FLHSETVQEA QDIAITAHAL ARKSGKGVIH FFDPSNSAKD PSIPEEDIEV
VKKVLSVGGN SAISAGTQTL YADSGRVATV TAETVGTSPS GQSESTNLTV PSQPQTPFNA
SVDNSSVGSS RRDSSAGSET PSSTATTVDS ATIRPVNAAD IFDWTAQIWN TLFEEVGRRY
NAIEYTGVAD AKSAIFVFGS TGVFVDALAN AGANPELENI GLITARLYRP WVGGQISNSI
PSSVEKIAVL EQVRKTTRWG PSFMDLLSSL TPSGARAQPP QIVGYRLGYI EPSTAVQALR
GVLQNLNSAS PIQNLDIGSS QVPVVQHALE QPRIENAYLK ILDQLFGERL HIANQLGSNN
AGISSTIAAS PEFGFGSLLA RQEHRQRFIR EVEEATRSNG FATDVPKTWL SRWALNVKEA
AKANKLAPDV ISRLSNDGSA ISRQLLQSKQ LFYEESDWLV GSDAWAYDLG NSGVHHVLAS
GANVNMLIID SQPYSERTAS DANRRKKDIG LYAMNRGTAY VASVAVYSSY TQVLQAMSEA
QQFKGPSVVV AYLPYNQEND SALTVLQETK KAIDLGYWPL YRWNPDNEEK GEPKFQLDSE
RIKRDLEEFL RRDNQLTQLM NRQPKYAPVL SESYGTEVRA LQKRNAKDSY EKLLDGLFGA
PLTILFASDG GNAQNIAKRL GNRGRARGLK TMVIAMDEFP LEDLPTEENV VFITSTAGQG
EFPVNGRSLW EHVKNTGDLD LSTINYSVFG LGDSHYWPRK EDKIYYNKPA KDLDDRVAFL
GGRKLTDIGL GDDQDPDAYQ TGYSEWEPRL WKSLGVDKVE GLPEEPAPIT NEDIKINSNF
LRGTIAEALL DESTGAIPAS DQQLTKFHGT YMQDDRDLRD ERKAQGLEPA YSFMIRCRLA
GGVATPKQWL QMDAISSSHG NETMKLTTRQ TFQFHGVIKR NLRGAMRAIN NSMMDTLAAC
GDVNRNVMCS SLPELSSVHR ETWAISSKIS EHLLPSTTAY HEIWLKDDND KKVQVAGDAV
VDHEPLYGPT YLPRKFKITI AIPPHNDTDV YAHDIGLIAI KGADGNLEGF NVLAGGGMGS
THNNTKTYPQ TGRMFGYIPK DMVHIACEKI MLVQRDNGDR KNRKHARMKY TIDDMGVDAF
RSEVENRLPD GLKFGEPRPF EFKSNVDTFG WLKDDTGLNH FTFFIENGRI EDTADFKMRT
GLRELAEMGK GEFRLTGNQH LMISRITDED LPAIKEHMAK YKLDNTAFSG LRLSSSACVA
FPTCGLAMAE SERYLPVLIS KLESTLEECG LARDSIVMRM TGCPNGCARP WLAEVAFVGK
AFGAYNMYLG GGYHGQRLNK RYRSSIKEDE ILEIMKGLLK RYSLERDTDG ETPERFGDWC
IRAGVIKATT DGKDFHDGVA EDEEEE
//
