ID A0A1V8M4T9_9GAMM Unreviewed; 901 AA.
AC A0A1V8M4T9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=AU255_01305 {ECO:0000313|EMBL:OQK16571.1};
OS Methyloprofundus sedimenti.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methyloprofundus.
OX NCBI_TaxID=1420851 {ECO:0000313|EMBL:OQK16571.1, ECO:0000313|Proteomes:UP000191980};
RN [1] {ECO:0000313|EMBL:OQK16571.1, ECO:0000313|Proteomes:UP000191980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WF1 {ECO:0000313|EMBL:OQK16571.1,
RC ECO:0000313|Proteomes:UP000191980};
RA Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQK16571.1}.
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DR EMBL; LPUF01000001; OQK16571.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V8M4T9; -.
DR STRING; 1420851.AU255_01305; -.
DR OrthoDB; 9806130at2; -.
DR Proteomes; UP000191980; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OQK16571.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000191980};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 398..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 669..886
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 901 AA; 101387 MW; 25179128C8F7F356 CRC64;
MIGYNSCQIS PGTLPFLNNN KHPNHGHLKI FVGAASGAGK TYAMLTAAKE RLKNGESVLA
GWVETHGLHD TALLLENFKV LPKKSVLSQG RELEEFDLDE AIRRRPQLIL IDELAHSNLP
GGRHRWRHQD IAELLTAGVD VYTTLNIYNL ASLSDTVLQM TGVRIDETVP NQIIDNADDL
ILIAPPTKTL LERFRNGKVS LPEFLLPTGK NFFLPSSLTA LRELAIREVT ERSDAHLKSE
LQNKDNILDF VIYEKLLVLI SHRRDQKYLI RLGRQIADRR QIPWLVVWVD TGQPRYQKDS
ARLQAAFSLA KNLGAKTETL RGPNTFQTIL PFITEQRINT VLVGAGKRHK FFPWRKNLYQ
RLIESGLPIE VSVFRKKPSS VDVKRVEDSN ICIWGNKFGH VFSIFAVLFA TLLAIPLEYW
LSNANLVMLY VLAVMITGLK HGSVPAILAS ILSFLSFNFF LTEPRHSLAV DRQDELYTLV
FLFMIALFSG PAASRIRRQF ILLREANRYS ESMRLLGQEL SVAEDSKAVW NALVKKLHNI
MQAECCIVMP TEHKNHTIYP HPPVEFQPID FSAIEWTLHH AEPSGRFTDT VTKSAWTVFP
ITKDGETIAA VILRLDSKVS GLRSHDKELI QTMIQQAADT WRRIQLVSEL ESARVKTKIE
QLRSALLSSV SHDLKSPLAA MMGAAESMRL LDKQLNTEDR LELVDTILSE SRRLDSYIQN
LLDMTRLGHG SLKIERDWAS VTDIIGSAII RLKRSFPTVK TEYRENPPLP LLFVHAALIE
QALFNILENA AKFSPPEETI KITVSVKNKT CLINVEDQGP GVPEPFREKI FDMFYVVSDG
DRKKPSTGLG LAICRGMVGA HGGSVKAMAG MDHKGTRIVV ELPIDYPIVS ETNNPIKTIN
S
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