ID A0A1V8T134_9PEZI Unreviewed; 1055 AA.
AC A0A1V8T134;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Protein HIR {ECO:0000256|RuleBase:RU364014};
GN ORFNames=B0A48_08136 {ECO:0000313|EMBL:OQO05116.1};
OS Rachicladosporium antarcticum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Cladosporiales; Cladosporiaceae; Rachicladosporium.
OX NCBI_TaxID=1507870 {ECO:0000313|EMBL:OQO05116.1, ECO:0000313|Proteomes:UP000192596};
RN [1] {ECO:0000313|Proteomes:UP000192596}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCFEE 5527 {ECO:0000313|Proteomes:UP000192596};
RA Coleine C., Masonjones S., Stajich J.E.;
RT "Genomes of endolithic fungi from Antarctica.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|ARBA:ARBA00002677,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQO05116.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NAJO01000020; OQO05116.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V8T134; -.
DR STRING; 1507870.A0A1V8T134; -.
DR InParanoid; A0A1V8T134; -.
DR OrthoDB; 5478541at2759; -.
DR Proteomes; UP000192596; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF07676; PD40; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000192596};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 13..45
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 66..107
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 126..167
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 168..199
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 722..970
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 628..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 977..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 977..995
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1055 AA; 114251 MW; F91DEBDCE6821B18 CRC64;
MRFTKPLWLS HGGEKREHEV YSCHVSPDGS RLATAAGDGH VRIWSTDAIL NASDPAYTKP
KQLASLSHHS GTIHSVRFSA NGKYLASGAD DKIVCVYNLD PSPPSHTTFG SNETPPVENW
RIFRRLIGHD NDVQDLGWSC DSSILVSVGL DSKAVVWSGS TFEKLKTLSN HQSHVKGITF
DPSNKYFATA SDDRTIKIFR FTPPPPNASA YDQTSNFTLE HTVSAPFSTS PLTTYFRRCS
WSPEGAHIAA ANAVNGPVSS VAIINRGTWD GEINLIGHEG PVEVCAFSPR LFYQRPHDKD
VPQSSVTIIA CAGQDKTLSV WNTSFPRPFV TTAELAAKPI SDLAWSPDGE TIYYTSLDGT
IAAVVFERGE LGYPAPTADN DKALAKYGAG RRVGIVENAD ALRLEEGSKA GELRGVEGRM
GELMGDSQPQ PSVLTNGDAH VNGTANVTGA AEPAATAPAP PKDPQAEKID KLKQRVTITK
DGKKRIAPLL LSSSNQGESN LPRTQLQAAV RHGAVSDAPA TILDLSKPYD GLPKGGLSGL
LMGNKRKYAE VEGDDEKRAE KRVHLVQQTG AAPIVSNTPD GLVPASTAPS KPIEVPEVLR
PAITNPSMTV SQIRLAVPMV RSVIIRPREP ARSIPDSDTT STAPAEPPDA DKPLIFEARN
ATGPSRTGRA QDREPSRITV SKRAQTLWQD YLPKAVLLVT GNSHFWAAAC EDGSLHVWTP
AGRRLLNALI LDSQPVILDC RGWWLLALTA TGQCHIYNLR TLSAPHPPIS LAPILDTASA
VQHPHLTPSP SLIFARLNSA GRIIAALSNG EGFTYSPALH TWQRLTENWW AVGSQYWNTT
DTSLATPAAI AKNLRPQASS CSGVPPAWHE TINPENLSAG IIPLLERHTT AQALLKGRAY
FLQRLVKMLI SAEGYEGFES AVSIAHLENR IAAALTLGAR DEFRVYLVTY AKRLGAENLR
AKVEELLRGL MGRLYEDEED GDDGEGDEEG EGVEWGEGNE VCGWKREELL REIVVVLGKW
RELQRVTVPY AKLLGVIGEA AEGAGKEGEE MEVET
//
