ID A0A1V8T902_9PEZI Unreviewed; 1411 AA.
AC A0A1V8T902;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Pre-mRNA-splicing factor {ECO:0000256|PIRNR:PIRNR038901};
GN ORFNames=B0A48_06620 {ECO:0000313|EMBL:OQO07829.1};
OS Rachicladosporium antarcticum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Cladosporiales; Cladosporiaceae; Rachicladosporium.
OX NCBI_TaxID=1507870 {ECO:0000313|EMBL:OQO07829.1, ECO:0000313|Proteomes:UP000192596};
RN [1] {ECO:0000313|Proteomes:UP000192596}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCFEE 5527 {ECO:0000313|Proteomes:UP000192596};
RA Coleine C., Masonjones S., Stajich J.E.;
RT "Genomes of endolithic fungi from Antarctica.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in mRNA splicing where it associates with cdc5 and
CC the other cwf proteins as part of the spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBUNIT: Belongs to the 40S cdc5-associated complex (or cwf complex), a
CC spliceosome sub-complex reminiscent of a late-stage spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SIMILARITY: Belongs to the CWF11 family.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQO07829.1}.
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DR EMBL; NAJO01000013; OQO07829.1; -; Genomic_DNA.
DR STRING; 1507870.A0A1V8T902; -.
DR InParanoid; A0A1V8T902; -.
DR OrthoDB; 7041at2759; -.
DR Proteomes; UP000192596; Unassembled WGS sequence.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd17935; EEXXQc_AQR; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR048966; Aquarius_b-barrel.
DR InterPro; IPR048967; Aquarius_insert.
DR InterPro; IPR032174; Aquarius_N.
DR InterPro; IPR026300; CWF11_fam.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF5; RNA HELICASE AQUARIUS; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF16399; Aquarius_N_1st; 1.
DR Pfam; PF21143; Aquarius_N_2nd; 1.
DR Pfam; PF21144; Aquarius_N_3rd; 1.
DR PIRSF; PIRSF038901; AQR_cwf11; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|PIRNR:PIRNR038901};
KW mRNA splicing {ECO:0000256|PIRNR:PIRNR038901};
KW Nucleus {ECO:0000256|PIRNR:PIRNR038901};
KW Reference proteome {ECO:0000313|Proteomes:UP000192596}.
FT DOMAIN 16..402
FT /note="RNA helicase aquarius N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16399"
FT DOMAIN 482..647
FT /note="RNA helicase aquarius beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF21143"
FT DOMAIN 696..787
FT /note="RNA helicase aquarius insertion"
FT /evidence="ECO:0000259|Pfam:PF21144"
FT DOMAIN 804..1097
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 1108..1300
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 718..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1374..1411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1381..1411
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1411 AA; 158397 MW; A4FD9B0E38B390B3 CRC64;
MQRPTVHDLT SDDNHFAQLA RRTWLTAKPA KVLPSIIKDG LYDKLEAESF PQPQLALLEQ
LQCLERYLWP GYADDASNQH ILLILLLVNV KRQANLPIWS LFEASPDAFS SFFKRVLHMS
IDASLPVSVR QHVLVFIITA FQSLDSGVVR RECAPLVSVA IWTNLHSESE RERKLAGNVA
LQKAWRAAGK KYSNADDEGQ ARIRFERSWL YTLVLDFLAR LYGVEGNADQ RQTNVRYCER
SLELLCDLLS QLPTKRYVNA LLQDLNVLAA IKLSPRYQDE DSSLLRELHE ILAHYIGFPI
DDQSGKQLSR QEYEELSNAG IARLQRAALQ LHPEKLKILI LANYGLLSQR TELQSHLADL
SDSELLKLVS ELGLRSRYPE KSSVITDRTF LLEVVVTALE AKPYYTDAVR DMTTMPTERV
LYDKALLRTD DYDGTTPLAI PKLNLQYLTA GDFLWRSFIL YRAEAFYEIR KHLEDTVKRL
QPRRQASGIT RFDGFSSMAI PITKPAIIET LPPRVGEDVP AEVKAEVMLD VSRLQPKLRQ
EWESVRPDDV VFLLNVQAQD RALTNGHGSD LTPINEKLGL KAVRSAEIIS VLDEAGRMLR
RDGPPGDDSS RPRQRRLLLR LDAASYKQDQ ADSKADPIDG INLIIRRRAR ENTFKAVLDS
VKDLAVSDAP LPAWFQDVFL GYGDPATVTA ARLTDKTKAV DYRDTFLDWQ HLIESFPGQP
VEPDGNANGS FPPPYVLEST TAAPAAPPRT AKKRKREAEA EPVAQDVQAI KVSTYEPPNA
GPYPTDAPKV NKVRFTPAQV KAVSSGTKPG LTLVVGPPGT GKTDVATQII SNIYHNYPEQ
RTLLVAHSNQ ALNQLFQKIT ALNIDERHLL RLGHGEEELT TEASYSKAGR VESFLERGSQ
HLAEVQRLAN SINAPGAHGS TCETATYFDQ VYATPMWKRF WTAAEGLTSA EDISSIFPFH
VFFADASQPL FPANTPHASL LDIARGCETH IRRIFTELAS IRPFELLRSP RDKANYLLIK
EARIIAMTST HAAMRRQEIA SLGFQYDTVV MEEAAQLTEI ETLIPFALQN PTPGKIPTSR
LKRIVLVGDH LQNAPIIQNA AFRQYANLEQ SLFLRLVRLG VPICMLDAQG RARPSLAALY
KWRYPSLTNL PITTTSPEFQ RANAGLRYDY QFIDVPPYRG VGESEPSPHF IQNLGEAEYV
VAMFQYLRLL GYPAHRISIL TTYAGQRALI RDVLGHRCKG KAMFGMPGWV GTVDKYQGEE
NDFVLLSLVR TKTVGYLRDL RRLTVALSRA RLGLYVFGRR EVFESSLEVR QAFSLLFARP
EKLTLVVNEL YPTQRGVEDE VEGTEMEGLE HLGSYIPVMV KAKLEQIKQE GGQIVAEDSG
GRMEDEEDEA GGEALAEDVA EMEGIEEDEV V
//
