ID A0A1V8TGP1_9PEZI Unreviewed; 1288 AA.
AC A0A1V8TGP1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Antiviral helicase {ECO:0008006|Google:ProtNLM};
GN ORFNames=B0A48_03847 {ECO:0000313|EMBL:OQO10549.1};
OS Rachicladosporium antarcticum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Cladosporiales; Cladosporiaceae; Rachicladosporium.
OX NCBI_TaxID=1507870 {ECO:0000313|EMBL:OQO10549.1, ECO:0000313|Proteomes:UP000192596};
RN [1] {ECO:0000313|Proteomes:UP000192596}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCFEE 5527 {ECO:0000313|Proteomes:UP000192596};
RA Coleine C., Masonjones S., Stajich J.E.;
RT "Genomes of endolithic fungi from Antarctica.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQO10549.1}.
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DR EMBL; NAJO01000008; OQO10549.1; -; Genomic_DNA.
DR STRING; 1507870.A0A1V8TGP1; -.
DR InParanoid; A0A1V8TGP1; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000192596; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 2.30.30.1160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR InterPro; IPR040801; Ski2_N.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR Pfam; PF17911; Ski2_N; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000192596};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 320..476
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 609..810
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 203..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1288 AA; 144009 MW; DE757422808AFD6F CRC64;
MDDSLTSAFE RLRVGADKIE SIDSILDDPK PRTRLRRTPD EVKQQLEIDF LTPSTSFSPQ
WLNKLQQRWD APTNYSELFS LAPTQTRTII RFTREGLEGR VTGYKEVTVP ANSATAKNST
SLLRKPANRA EFVRGAAGFY PFAPGGLEGV EATAAAEDEF LAAREVNGGR KASKLDRVID
FAAEGGLLSV PPGFERGLRL PEKAEKAEDD AAEEVERVLE EETEQKDEAN WVDGADEANG
DADVTSDDEG SEEEVDALLP VEFPALAPHA PLLSARNKHG GREWAHMVDV NRDIANFKDL
VPDMARTWPF ELDTFQKEAV YHLENGDSVF VAAHTSAGKT VVAEYAIALA AKHMTKAIYT
SPIKALSNQK FRDFRLEFDD VGILTGDVQI RPEASCLIMT TEILRSMLYR GADLIRDVEF
VIFDEVHYVN DSERGVVWEE VIIMLPEHVT LIMLSATVPN TFEFASWVGR TKKKDIYVIS
TPKRPVPLAH YLWADKRMIK IVDENKHFLE KGWKDANDAL SGRDKIIAAE AKAKEKEDAA
VAAGRGGRGN ARGGPAGRGG APRGGPAQRG GAQQRGRGAP ATRGQGNIAR TGRGGGRTSA
AQDKTLWVHL VQHLKKEELL PCCIFVFSKK RCEENADALS NLDFSNAAEK SATHMILEKS
LARLKADDRD LPQIRRIREL LSRGIAVHHG GLLPIVKECV EILFAKTLVK VLFATETFAM
GLNLPTRTVV FSGFRKFDNK GFRDLLPGEY TQMAGRAGRR GLDTVGYVLL VSAGAEEAPP
AGRLRQMMLG EPTKLRSQFR LTYNMILNLL RVEALKIEEM IKRSFSENAT QALLPEHEKQ
IRLSEADLAK VKRESCETCD KDIEACHDAS VMFEQYTQDL HLAMLGTPVG RRMFQPKRII
VFKNQNGVRT VGVLLREGAS RGANAGVQTL EVAYKKKTKR QDADFLPFLP RFRRHFTALP
QTDAEMDLRL TTVPVNDIEA LTANHLQMDV NAVMRKEPTE WAKAKADLLQ LCSSWASSTW
NELDHLKWLK AMTVRNLLDD RLRFATLAQQ CACIHCPNFP RHFAMAHDQW IIKDKIDSIR
SLMSDQNLQL LPDYQQRISV LKDLGFIDDN SRVELKGKVA CEIHSADELV LTELILENVL
AEYEPEEIVA LLSSFVFQER TDSSPNLTPA LEKGIETIIK ISENVNRYQT LHQVILSSDD
SNDFVSRPRF GLVEVVYEWA RGMPFSRITD LTDVLEGTIV RVITRLDETC RECKNAARII
GDPTLFAKMQ SCQELIKRDI CATASLYM
//
