ID A0A1V8THI2_9PEZI Unreviewed; 994 AA.
AC A0A1V8THI2;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=B0A48_04148 {ECO:0000313|EMBL:OQO10847.1};
OS Rachicladosporium antarcticum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Cladosporiales; Cladosporiaceae; Rachicladosporium.
OX NCBI_TaxID=1507870 {ECO:0000313|EMBL:OQO10847.1, ECO:0000313|Proteomes:UP000192596};
RN [1] {ECO:0000313|Proteomes:UP000192596}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCFEE 5527 {ECO:0000313|Proteomes:UP000192596};
RA Coleine C., Masonjones S., Stajich J.E.;
RT "Genomes of endolithic fungi from Antarctica.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQO10847.1}.
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DR EMBL; NAJO01000008; OQO10847.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V8THI2; -.
DR InParanoid; A0A1V8THI2; -.
DR OrthoDB; 1330110at2759; -.
DR Proteomes; UP000192596; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF154; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000192596};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 38..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 670..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..715
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..199
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 223..389
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 401..684
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 858..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 319..346
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 863..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..896
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 994 AA; 111778 MW; BCF110C045985CB5 CRC64;
MAAALWARQD DGGGKSGTDE LLNLLANPYG GTLSTNSFFA SLGTSLGATA VIALLFCFLR
PYNNVVYAPR AKHADSKHAP PPVSKGIFGW IPPLMRTTEQ DLVDKVGLDA AIFMRFTRMC
RNMFVVLSIV GCGVLIPVYL LSANEYTPQR KRQDNYSTGQ GVSFFYKLTP QNMYFSKSFW
ALVVVAYVFD IVVCYFLYHN YVAVLRLRRA YLDSPEYQRS LHARTLLLTD IPNDYRTDDG
IVRLTDEIRA TDSVPRAAIA RNVKELPELV EEHEDAVRKL EKYLAKYLKN PDKLPAQRPM
CKASSKDKTY SKGQKVDAIE YLTARIKNLE IEIKQVRETI DKRNALSYGF ASYDQISEAH
GAAYVARKKG PQGSIVRLAP RPNDLVWKNL KMAKKDRNWQ NFINNLWVAV LTLFWTAPNV
FIAVFLANLA NLGKVWPAFN QSLLDHPKWW AVVQGVAAPA VTNIFYYYLP AIFRRLCISS
GDVTKTSRER HVMHKLYTFF VVNNLIIFSI FAALWGFVVN VINANKDKNE GVWEAITHGK
FFLSVITTLC QISPYWIGWL LQRNLGAAVD ISQVVNLAWG SISRKWFSPT PRELIELSAP
QPFDYAGYYN YFCYYATVAL AFATIQPLVL PVVLFYFFLD SWLKKYLLLY VFITKYESGG
MFWRTIFNRM LVAAFLGNVV VALVVVAFGS VGINWAMLAA LGPLPFLLAA FKWYCARKFD
DQIHYYQKGN AIKDREEHAG SEHKTRKSDR VGVRFGHPVL YKPLMTPMVS AKSQHLLKQI
YSGRTSVEDS RTVGGYSDVY LDAMDSNAPG KASGKNPAPF ELVDENQMDF EHYKNRPEFR
DEAGGDGELY GRAADLIRPG TPSTIMTGVT RTGTMESYDR SRSTSRHDRN RSDDSDSTRV
APVGGTDYPR GYHQTPHMRE QSPAGSDFGD GFAGRGRPGL GHAPSREGLV GGAARMGMSP
PPKMPGGYGN LRSENTTPGE ESTSYDYFRR GRGL
//
