ID   A0A1V8UCH1_9PEZI        Unreviewed;       656 AA.
AC   A0A1V8UCH1;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   13-SEP-2023, entry version 28.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OQO21063.1};
GN   ORFNames=B0A51_11470 {ECO:0000313|EMBL:OQO21063.1}, B0A51_14310
GN   {ECO:0000313|EMBL:OQO19365.1};
OS   Rachicladosporium sp. CCFEE 5018.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Cladosporiales; Cladosporiaceae; Rachicladosporium.
OX   NCBI_TaxID=1974281 {ECO:0000313|EMBL:OQO21063.1, ECO:0000313|Proteomes:UP000192386};
RN   [1] {ECO:0000313|EMBL:OQO21063.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CCFEE 5018 {ECO:0000313|EMBL:OQO21063.1};
RX   PubMed=28684563;
RA   Coleine C., Masonjones S., Selbmann L., Zucconi L., Onofri S., Pacelli C.,
RA   Stajich J.E.;
RT   "Draft Genome Sequences of the Antarctic Endolithic Fungi Rachicladosporium
RT   antarcticum CCFEE 5527 and Rachicladosporium sp. CCFEE 5018.";
RL   Genome Announc. 5:e00397-17(2017).
RN   [2] {ECO:0000313|Proteomes:UP000192386}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCFEE 5018 {ECO:0000313|Proteomes:UP000192386};
RA   Coleine C., Masonjones S., Stajich J.E.;
RT   "Genomes of endolithic fungi from Antarctica.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC       {ECO:0000256|ARBA:ARBA00006743}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQO21063.1}.
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DR   EMBL; NAEU01000772; OQO19365.1; -; Genomic_DNA.
DR   EMBL; NAEU01000594; OQO21063.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V8UCH1; -.
DR   STRING; 1974281.A0A1V8UCH1; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000192386; Unassembled WGS sequence.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00537; MTHFR; 1.
DR   Gene3D; 3.20.20.220; -; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR004621; Fadh2_euk.
DR   InterPro; IPR003171; Mehydrof_redctse-like.
DR   NCBIfam; TIGR00677; fadh2_euk; 1.
DR   PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR   Pfam; PF02219; MTHFR; 1.
DR   SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192386}.
FT   REGION          631..656
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        632..656
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   656 AA;  73422 MW;  5893365E4CDC632A CRC64;
     MHITKKLAAS HAKGEPTYSF EFFPPKTSQG VQNLYDRMDR MHGFGPAFID ITWGAGGRHS
     QLTCEMVKVA QSVYGLETCM HLTCTDMETS KIDEALKEAY NSGCTNILAL RGDPPREQEK
     WEQAEGGFRY ARDLIKYIKT NYGDHFDIGV AGYPEGCDET TGSEEHIPYL KEKIDAGGTF
     IVTQMCYDAD IFIDWVHRCH AAGIPESVPI IPGIMPIHTH ASFMRRATWT QCHIPPEWHE
     KLEPVKNDDV SVREVGKELV ADFCRRVLDS GTTMHLHFYT MNLAVATRMV LEELAVTPPS
     NEHNPLLKPL PWRQSLGLNR RDENVRPIFW RNRNRSYVAR TQDWDEFPNG RWGDSRSPAF
     GELDTYGVGL KGTNEENRKL WGSPESNRDI ADLFVGYMKG SVKSLPWSEA PINTEANVLQ
     SDLIDLNGRG LLTINSQPAV DGAKSNHQDY GWGPKNGYVY QKAYLEVLVH PNLIDTVISR
     MERDEDITYY AVNSSGSLRT NVPVDCGPNA VTWGVFPGKE IVQPTIVETV SFLAWRDEFY
     HLGSEWAKCY AEGSASKTLI KDVVDNWYLV NIVHNDFRQA RGIFPLFEGL SAPGLSVTEQ
     ANGNGYVNGH VNGGAENSDL SFRKKPETNG VYDGNNAVNG ADHANMTNGQ NGEVEA
//