ID A0A1V9K298_9ACTN Unreviewed; 2579 AA.
AC A0A1V9K298;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:OQQ13712.1};
GN ORFNames=B0675_25960 {ECO:0000313|EMBL:OQQ13712.1};
OS Streptomyces sp. M41(2017).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1955065 {ECO:0000313|EMBL:OQQ13712.1, ECO:0000313|Proteomes:UP000192467};
RN [1] {ECO:0000313|EMBL:OQQ13712.1, ECO:0000313|Proteomes:UP000192467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M41 {ECO:0000313|EMBL:OQQ13712.1,
RC ECO:0000313|Proteomes:UP000192467};
RX PubMed=28326787; DOI=10.1021/acs.orglett.7b00545;
RA Wyche T.P., Ruzzini A.C., Beemelmanns C., Kim K.H., Klassen J.L., Cao S.,
RA Poulsen M., Bugni T.S., Currie C.R., Clardy J.;
RT "Linear Peptides Are the Major Products of a Biosynthetic Pathway That
RT Encodes for Cyclic Depsipeptides.";
RL Org. Lett. 19:1772-1775(2017).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQQ13712.1}.
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DR EMBL; MWFK01000002; OQQ13712.1; -; Genomic_DNA.
DR STRING; 1955065.B0675_25960; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000192467; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000192467}.
FT DOMAIN 968..1042
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2492..2567
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2579 AA; 275586 MW; 7C69268426DD2693 CRC64;
MIPLSFAQRR LWFLHRLEGP SATYNIPFAL RLEGPLDTTA LAAAVTDVAT RHETLRTLIV
EDADGTPGQR ILPPAEAVLP FTVTDTTPGE LDAALDTVLR RGFHLESQLP LRTTVFRLAP
QEHVVAFVFH HIAVDGASMA PFLTDLVTAY TARRQGRPPN WTPLPVQYKD YTLWQRQLLG
DEDDPESVAA AQIDYWRTEL DGVPQPVQLP LDRPRPTMPG HHGGHVSFIL EPELLTGIGK
LAADHGATAP MAAQAALALL LHKLGGGHDV TIGSPIEGRA DEQLDDLIGF FVNTWVLRAD
LATAPTFADL LEQVREKALA AYDNQDLPFE RLVELLGQDR ATSYQPLFQT MLAWQFVWPQ
IHLPGLNATP LAADTRSAKF DLFFNVVPDA DGGAYGRLEY AEELFDQSTA AAIADRFVRV
LRHVVADPGA PLTALDVRTD AEREDQARRN DTATPHAATT LPELLAAQRA RTPDAPAVIH
AATTLTYRQL DERAARLAAH LRAHGAGPDV LVAVALPRTA DLVVALLAVL KAGAAYLPVD
PQHPAARTRL LLTTARPALL LTDRATAPQA GLDADTAPVL HLDDLDLTGP APALPAVRVR
PDDLAYVMFT SGSTGTPKGV AVTHAGVVNG ITDLRRTVHA GPGERMLAAT SVNFDVSVFE
IFTALTTGAS VEIVRDVLEL AERDAWSGTT ISAVPAVFSA LLDHITHHPG SLRLTVDTLV
LAGEALTADL VDKARTVLPG VRIVNAYGQT ESFYATTHTL PQESAPTGAL PIGRPLANLR
THVLGPDLTP VPPGVIGELH VAGILARGYH DNPAATAQRF LPDPFGAPGE RMYRTGDLAR
WDADGHLVYA GRADTQVKIN GIRIEPTEIE TVLTRHPAVG QAVVTVHQDP AAGTRLVAHL
APPAAAEEAA APAVIDESDV RRFAARHLPD YMVPAALVTL ERLPLTASGK LDRAALPAPV
FTSAGHRPPR TATEQTLAEV YADVLAASRV GIDDDFFTSG GDSIRSIQVV ARATARGVRI
STRDIFEHRT IARLAELIEA RGAEQRPVLA ELPGAGVGWA PLTPTAAHVL ALGAGTGRFS
MSALLTLPDG ITPAQLTATL QTLLDRHDVL RSRLVRLQPG LRMEPPGAVD AATLLHRRPY
DPTTVQAELD AAAARLDPDT GVMAQFVHLT DDTGPGRLLL VLHHLVVDGV SWRILLPDLA
DAWQHVRDNL EPPPAPASTS LRRWAHALAE TANTPQREAE LPHWQQILRE GEPPLGSRRT
DPAQDTAATT DTVRVRIPAD ITHTLLTTLP ALYRGGADDA LLTGLALALA RWRARHDTPA
PATLVRLEGH GREEHLVPGA DLTATIGWFT AMYPVRLDLA GLDLADAFAG GPAAGAALKA
VKEHLRTVPD NGLGHGLLRH LNPRTAPVLA ALPQPQIGFN YLGRASAADL PEHLRSAGFT
PDTGHQDLIA ADDPDMPVLS ALEINTVAAP TDEGDELSAY FGFATGVLTR PQVTELADLW
VKALTALAHH TTTDGAGGLT PSDVPLAEVN QTEIDGWEQR FGPLTQVWPV TPAQSGMLFH
TLLAGTSAFD AYRMQLVFHL DGDADPERMR RAGHALLERH PGLRAAFVER ADGEAVQVIP
TTAPLPWRHL DLTARPDEER TAAFERFLEE DRAAPFDLTE PPLLRLALVT LEPGRAELVL
TAHHALFDGW STPLLLQDLL FLYASGGDGS VLPPARDFGD FLSWRARQDP QESARAWAGE
LDGLAEPTLL APGAEQAGDE GLDEVDVTLP PELARSLPRA AAAMGVTANT LLQGAWALLI
GQLTGRQDVV FGATVSGRPA AVTGVESMVG MFINTLPVRV THAPGDTIAG LLSRLQQRQA
ALTDHHHHGL TEIQQPTGLP ALFDTLVVFE SYPVDEDGLN AAGAASGGLT VTGLRHATGT
NYPLTLTALV EPQLKLTLQY ARAVFGRATV ETYAARLVRV LARLADSPHL PASRLDTLSD
GERERLLEAF NDTAAPTPDT TIGALIEQQS ARTPDASALI AGQTTLTYRE LNRRSDALAH
ELAARGGGAE SLIALSLPRT ADLVIALLAV LKAGCAYLPL DPKYPGHRLA AILTDARPAL
LLTDTPTSAL LPDHEATTVL IDTLDPAAHP AAPPQQAVHP DQLAYVMYTS GSTGRPKGVA
ITHAGVVNGV LHLADRLDLG PGKRLLAGAS VNFDVSAFEI FTTLATGGTV ELVRDVLVLG
ERERWSGSVI STVPSAFAEL LDRITGRTEV ESVVFAGEAL PAALADRTRQ AFPGVRVVNA
YGQSETFYAT THTTAPQDGG PGSVPLGAPL DNMRAYVLGP GLIPVPPGAA GELYVGGAIG
RGYHDRPTLT AARFVPDPHG APGARMYRTG DLARFTAEGL LEYAGRSDAQ VKVRGFRVEP
GEVEAVLTAH PHLAQAAVIT HGTGTATRLV GYAVPEQETS AQEIRRHAAE HLPEYMVPSA
VVLLERLPLM PNGKLDRAAL PEPEYTAAPY RAPRTPREET LAALFAEILG RDRVGIDDGF
FELGGHSLLA TRLISRARAE AGIEIPIRTI FDLPTVAELA AWSQESAAPR RPSLRQMFA
//