ID A0A1V9K2S6_9ACTN Unreviewed; 560 AA.
AC A0A1V9K2S6;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 13-SEP-2023, entry version 18.
DE SubName: Full=Aspartate-alanine antiporter {ECO:0000313|EMBL:OQQ13883.1};
GN ORFNames=B0675_27095 {ECO:0000313|EMBL:OQQ13883.1};
OS Streptomyces sp. M41(2017).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1955065 {ECO:0000313|EMBL:OQQ13883.1, ECO:0000313|Proteomes:UP000192467};
RN [1] {ECO:0000313|EMBL:OQQ13883.1, ECO:0000313|Proteomes:UP000192467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M41 {ECO:0000313|EMBL:OQQ13883.1,
RC ECO:0000313|Proteomes:UP000192467};
RX PubMed=28326787; DOI=10.1021/acs.orglett.7b00545;
RA Wyche T.P., Ruzzini A.C., Beemelmanns C., Kim K.H., Klassen J.L., Cao S.,
RA Poulsen M., Bugni T.S., Currie C.R., Clardy J.;
RT "Linear Peptides Are the Major Products of a Biosynthetic Pathway That
RT Encodes for Cyclic Depsipeptides.";
RL Org. Lett. 19:1772-1775(2017).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the AAE transporter (TC 2.A.81) family.
CC {ECO:0000256|ARBA:ARBA00009854}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQQ13883.1}.
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DR EMBL; MWFK01000002; OQQ13883.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V9K2S6; -.
DR STRING; 1955065.B0675_27095; -.
DR OrthoDB; 5166626at2; -.
DR Proteomes; UP000192467; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR022457; Asp_Ala_antiprt.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR006512; YidE_YbjL.
DR NCBIfam; TIGR03802; Asp_Ala_antiprt; 1.
DR NCBIfam; TIGR01625; YidE_YbjL_dupl; 1.
DR PANTHER; PTHR30445:SF8; TRANSPORT PROTEIN YBJL-RELATED; 1.
DR PANTHER; PTHR30445; UNCHARACTERIZED; 1.
DR Pfam; PF06826; Asp-Al_Ex; 2.
DR Pfam; PF02080; TrkA_C; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 2.
DR PROSITE; PS51202; RCK_C; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000192467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 206..287
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
FT DOMAIN 292..375
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 560 AA; 58380 MW; C3B930461C4EA714 CRC64;
MGVIKDHPEL AIFLCLGAGY LVGKLRIGPI TLGGICGTLI VSLLLGAWTK VQVSDDVKTV
FFAIFIFALG YMAGPQFFDN LNKKSLRFFA LCGIELVCVV GIALGIAQAF DLDVGTASGI
LAGAATESAV VGTATEAIGN LSNLTSQQIS TYQGHVATAY TVCYLFGLVT IVIYTSQLMP
MLLRINLADS SRALWQKMRG GGGGLASDER EALPGMVGRT FLVTTADGLP VADLERHLGG
RVTVEAVKRG SKVLTPPPPD FTLTLSDLVL AVGRRANIIE AGRLIGPETP AVPGLDTALA
TTQVSLTDKS VAGRTLDTLN REHPEFTTNG VYVTEVQRGD QVLPASPETE VRRGDVLTLV
GARSGLGRLV AKIGSVVKND TTDFVYLGAG ITAGSLLGQV VVTFGDVPLS LGTGGGCLVS
GLLFGWFRSR SQTFGAFPPQ AATTLKDMGL AVFIACTGLV SGPQAWPLLK EYGALLPFAG
IAMVVVPATV SLIVGRRFLK IEPPLLIGAI AGQQCSTPAI TSVTQVAQSS VPMLGYTITY
ALSNFLLPLT GPLLVGILGT
//
