ID A0A1V9K492_9ACTN Unreviewed; 705 AA.
AC A0A1V9K492;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Membrane transport protein MMPL domain-containing protein {ECO:0000259|Pfam:PF03176};
GN ORFNames=B0675_30105 {ECO:0000313|EMBL:OQQ14398.1};
OS Streptomyces sp. M41(2017).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1955065 {ECO:0000313|EMBL:OQQ14398.1, ECO:0000313|Proteomes:UP000192467};
RN [1] {ECO:0000313|EMBL:OQQ14398.1, ECO:0000313|Proteomes:UP000192467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M41 {ECO:0000313|EMBL:OQQ14398.1,
RC ECO:0000313|Proteomes:UP000192467};
RX PubMed=28326787; DOI=10.1021/acs.orglett.7b00545;
RA Wyche T.P., Ruzzini A.C., Beemelmanns C., Kim K.H., Klassen J.L., Cao S.,
RA Poulsen M., Bugni T.S., Currie C.R., Clardy J.;
RT "Linear Peptides Are the Major Products of a Biosynthetic Pathway That
RT Encodes for Cyclic Depsipeptides.";
RL Org. Lett. 19:1772-1775(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQQ14398.1}.
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DR EMBL; MWFK01000002; OQQ14398.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V9K492; -.
DR STRING; 1955065.B0675_30105; -.
DR OrthoDB; 2365435at2; -.
DR Proteomes; UP000192467; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000192467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 167..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 648..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..365
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 397..694
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 705 AA; 73045 MW; 2DFDC8A03A4237ED CRC64;
MSITPRRALW LIPVVLLVAW LGIGGTLGPY AGKLGEVATN DQAAFLPRSA ESTKVVSEQR
AFQQDETLPA IVVWTVDGAG SVRGEGQAAA TRALASLAGT PGVVGQASPA LPSGDGKALE
GVVQLRPDLG DELPDTLDRV RTATDRVPGT TARIAGPAAS QADLSDAFAG IDGLLLGVAL
ATVLVILLLV YRSVLLPFVI ILGAVFALGL ACAVVYVLAD HDVVRVDGQV QGILSILVIG
AATDYALLFT ARFREELALH DDRFTAVRAA LRQSWGAIVA SAGTVALGLL ALLLSDLTNN
RALGPVGAIG VVCAVLSTLT FLPAVLVLLG RAAYWPARPR ATGDAGAGSG VWRRVADLVD
RAPRKVWAIA LAGLLACAAF APTLTAKGVP LDEIFVDDAP SVAAQRTLSE HFPGGSGNPA
VIIAGADRLS QVITAARDTD GVASAAAVTE SGRPGGGDPK AVDGRVRVDV TLRAAADSDA
AKSTVARLRE AVHAVPDADA LVGGYTAQQY DTRQTAERDR TLIVPVVLAI ILVILAGLLR
SLLMPLLLVA TVALNFAATL GISSLVFRHV FGFSGTDASV PLYGFVFLVA LGVDYNIFLM
SRVREESLRH GVRQGVLRGL VATGGVITSA GVVLAATFAA LGVIPLAFLV QIAFIVAFGV
LLDTLVVRSL LVPALVRDIG RRAWWPGTLS REPAPVPHEG EHVRV
//