ID A0A1V9K6V1_9ACTN Unreviewed; 332 AA.
AC A0A1V9K6V1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=DNA polymerase III subunit epsilon {ECO:0000313|EMBL:OQQ15307.1};
GN ORFNames=B0675_35330 {ECO:0000313|EMBL:OQQ15307.1};
OS Streptomyces sp. M41(2017).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1955065 {ECO:0000313|EMBL:OQQ15307.1, ECO:0000313|Proteomes:UP000192467};
RN [1] {ECO:0000313|EMBL:OQQ15307.1, ECO:0000313|Proteomes:UP000192467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M41 {ECO:0000313|EMBL:OQQ15307.1,
RC ECO:0000313|Proteomes:UP000192467};
RX PubMed=28326787; DOI=10.1021/acs.orglett.7b00545;
RA Wyche T.P., Ruzzini A.C., Beemelmanns C., Kim K.H., Klassen J.L., Cao S.,
RA Poulsen M., Bugni T.S., Currie C.R., Clardy J.;
RT "Linear Peptides Are the Major Products of a Biosynthetic Pathway That
RT Encodes for Cyclic Depsipeptides.";
RL Org. Lett. 19:1772-1775(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQQ15307.1}.
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DR EMBL; MWFK01000002; OQQ15307.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V9K6V1; -.
DR STRING; 1955065.B0675_35330; -.
DR OrthoDB; 190275at2; -.
DR Proteomes; UP000192467; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProt.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd06127; DEDDh; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR006054; DnaQ.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR00573; dnaq; 1.
DR PANTHER; PTHR30231; DNA POLYMERASE III SUBUNIT EPSILON; 1.
DR PANTHER; PTHR30231:SF4; PROTEIN NEN2; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00292; BRCT; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Reference proteome {ECO:0000313|Proteomes:UP000192467}.
FT DOMAIN 21..185
FT /note="Exonuclease"
FT /evidence="ECO:0000259|SMART:SM00479"
FT DOMAIN 248..326
FT /note="BRCT"
FT /evidence="ECO:0000259|SMART:SM00292"
FT REGION 221..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 332 AA; 36139 MW; 990654E06A8A096E CRC64;
MLEDLTTAAS PASWPAAYPQ GYAVVDVETT GLARDDRIIS AAVYRLDARG EVEDHWYTMV
NPERDPGPVW IHGLTSDMLE GAPLFPEIAE EFAARLDGRV LVAHNAVFDW SMIAREYARA
EREAPVRQRL CTIALSKELG LPLPNHKLES LAAHFGVVQQ RAHHALDDAR VLAEAFRPSL
RAAARDGVRL PLLECLPLKE WSGSPSAPRI GRQAGGYASG GYPSGSWRPS RKRPACPYPN
PGRYESGKPL KQGMRVAFSG DTSVDRELLE DRAVEAGLHV ATSLSRLTSL LVTNDPDAAT
SKVVKARQFG TPVIDEAAFG QLLHDVEPAS HG
//
