ID   A0A1V9K9Z1_9ACTN        Unreviewed;       850 AA.
AC   A0A1V9K9Z1;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   ORFNames=B0675_03800 {ECO:0000313|EMBL:OQQ16389.1};
OS   Streptomyces sp. M41(2017).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1955065 {ECO:0000313|EMBL:OQQ16389.1, ECO:0000313|Proteomes:UP000192467};
RN   [1] {ECO:0000313|EMBL:OQQ16389.1, ECO:0000313|Proteomes:UP000192467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M41 {ECO:0000313|EMBL:OQQ16389.1,
RC   ECO:0000313|Proteomes:UP000192467};
RX   PubMed=28326787; DOI=10.1021/acs.orglett.7b00545;
RA   Wyche T.P., Ruzzini A.C., Beemelmanns C., Kim K.H., Klassen J.L., Cao S.,
RA   Poulsen M., Bugni T.S., Currie C.R., Clardy J.;
RT   "Linear Peptides Are the Major Products of a Biosynthetic Pathway That
RT   Encodes for Cyclic Depsipeptides.";
RL   Org. Lett. 19:1772-1775(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQQ16389.1}.
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DR   EMBL; MWFK01000001; OQQ16389.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V9K9Z1; -.
DR   STRING; 1955065.B0675_03800; -.
DR   Proteomes; UP000192467; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR031634; PknG_rubred.
DR   InterPro; IPR031636; PknG_TPR.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR24363; SERINE/THREONINE PROTEIN KINASE; 1.
DR   PANTHER; PTHR24363:SF0; SERINE_THREONINE-PROTEIN KINASE DDB_G0277989-RELATED; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF16919; PknG_rubred; 1.
DR   Pfam; PF16918; PknG_TPR; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:OQQ16389.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192467};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527,
KW   ECO:0000313|EMBL:OQQ16389.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          202..491
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          40..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          514..534
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..118
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   850 AA;  90052 MW;  2F23C2566FB65330 CRC64;
     MSEHAVGERQ GCQRPGCEGS YEDMGGGELY CDTCGLAPVV SAKGTVNSPP TGVTAGGGAA
     RGSTSGSVRG SSRASSRTSS RSSQSRRSVS GRLSRSVSGG STGRSVSVRS SGSTAGSSGR
     GRLGAGLVEV PGVPRPDPRE MVQENPEVPE RKRFCSRSDC GAPVGRSRGD LPGRTEGFCT
     KCGHPYSFVP KLQSGDIVHG QYEVAGCLAH GGLGWVYLAV DRAVSDRWVV LKGLLDTGDQ
     DAMAAAISER RFLAEIEHAN IVRIYNFVEH LDQRTGSLDG YIVMEYVGGK SLKEIANDRR
     TADGRRDPLP VEQACAYGIE ALEALGHLHS RNLLYCDFKV DNAIQTEDQL KLIDMGAVRR
     MDDDESAIYG TVGYQAPEVA EVGPSVASDL YTVARTLAVL TFDFQGYTNV FVDSLPDPGH
     IEVFRQYESF YRLLVRATDP DPARRFASAQ EMAEQLTGVL REVVSLQTGR ARPSLSTLFG
     PETKVTDTEL FGSVAGDVSR LGARVVPVRG RRAAPSLPAG GNGAAALPPP PDSPTLVKPV
     PAAAAALALP VPRVDPGDPN AGFLAGLIAS APAELIAALH AAPAGSPELR LRELRARLEM
     GEVAAAQHGV EALETDHPDD WRVVWYRGVT ALATGGNEIA ALSFDAVYDA FPGEPAPKLA
     LGLCAEVLGQ LDNAAEYYRL VWTTDPSYVS AAFGLARVQL AAGDRRAAVS TLESVPESSI
     HYTAARVAAV RARLRQRPVA DAAAPPFLDD LTAAAGQVEA LDGFGLDAVR REQLSTEVLG
     CALDWVLSGS QGSAPASGGG HVLLGSALDE RGLRFGLERS YRTLARLARG GEERIDLVER
     ANRYRPRTWV
//