ID   A0A1V9KAL2_9ACTN        Unreviewed;       805 AA.
AC   A0A1V9KAL2;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Helicase {ECO:0000313|EMBL:OQQ16620.1};
GN   ORFNames=B0675_05175 {ECO:0000313|EMBL:OQQ16620.1};
OS   Streptomyces sp. M41(2017).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1955065 {ECO:0000313|EMBL:OQQ16620.1, ECO:0000313|Proteomes:UP000192467};
RN   [1] {ECO:0000313|EMBL:OQQ16620.1, ECO:0000313|Proteomes:UP000192467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M41 {ECO:0000313|EMBL:OQQ16620.1,
RC   ECO:0000313|Proteomes:UP000192467};
RX   PubMed=28326787; DOI=10.1021/acs.orglett.7b00545;
RA   Wyche T.P., Ruzzini A.C., Beemelmanns C., Kim K.H., Klassen J.L., Cao S.,
RA   Poulsen M., Bugni T.S., Currie C.R., Clardy J.;
RT   "Linear Peptides Are the Major Products of a Biosynthetic Pathway That
RT   Encodes for Cyclic Depsipeptides.";
RL   Org. Lett. 19:1772-1775(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQQ16620.1}.
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DR   EMBL; MWFK01000001; OQQ16620.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V9KAL2; -.
DR   STRING; 1955065.B0675_05175; -.
DR   OrthoDB; 9787585at2; -.
DR   Proteomes; UP000192467; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   InterPro; IPR027785; UvrD-like_helicase_C.
DR   PANTHER; PTHR11070:SF45; ATP-DEPENDENT DNA HELICASE UVRD2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF13245; AAA_19; 1.
DR   Pfam; PF13538; UvrD_C_2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000192467}.
FT   DOMAIN          238..656
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          357..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         259..266
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   805 AA;  87432 MW;  7F71514C5E3525F3 CRC64;
     MAAQAQQESA VGSVRPSAAE KSAQDDSVRD REIGVEQHHL DRVYRRLEEK IHEAEFLMND
     AAQRGQVGTP GALAERDAQV FRAGIHLNRL NNEFEDFLFG RIDLLLGKDG KKGPDGAYTA
     VEPAEGAVRE DNTADIAETL HIGRIGVLDA DYSPLVIDWR APAAAPFYRS TPVDPGRVVR
     RRVIRSKGRK VLGVEDDLMR PELTAALDGR RLSVVGDGAL MAALGQARSH SMRDIVASIQ
     AEQDLVIRAP AASVTYVEGG PGTGKTAVAL HRAAYLLYQD RRRYAGGILI VSPTPLLVAY
     TEGVLPSLGE EGQVAIRAIG SLVDGVSATL YDAPAVARAK GSYRMLKVLR KAARGALETP
     GGANGRNGSG GSRDADSGQL AFGEPDTAPA GPPTRLRVVA FGRRIELESA ELDRIKHNAL
     GGTAPVNLLR PRARKLLLDA LWARSGAGTR HSDPELAAEL RSSFDEDVTS EDSFLTFLDA
     WWPELTPRGV LTAMADERRL GRWARRILNP GEVRRVARSL KRDGLSVHDV AMLDELQAIV
     GMPARPRKRR DLEPLDQLTG LEELMPVREE SQRERAERLA QERTEYAHVI VDEAQDLTPM
     QWRMVGRRGR HATWTVVGDP AQSSWSDPDE AAEARDEALG TRPRRRFTLT VNYRNPAEIA
     ELAAKVLALA MPGSDSPSAV RSTGVEPRFA VVRESLAQTV RAEAARLLDR VDGTVGVVVA
     MNRREEAARW LAGLGDRVVA LGSLEAKGLE YDANVVVSPA EIADESPAGL RVLYVALTRA
     TQQLTVVSSD RDDPDASGVP DLLRD
//