ID A0A1V9KIU5_9ACTN Unreviewed; 422 AA.
AC A0A1V9KIU5;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 08-NOV-2023, entry version 21.
DE SubName: Full=Beta-ACP synthase {ECO:0000313|EMBL:OQQ19386.1};
GN ORFNames=B0675_21665 {ECO:0000313|EMBL:OQQ19386.1};
OS Streptomyces sp. M41(2017).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1955065 {ECO:0000313|EMBL:OQQ19386.1, ECO:0000313|Proteomes:UP000192467};
RN [1] {ECO:0000313|EMBL:OQQ19386.1, ECO:0000313|Proteomes:UP000192467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M41 {ECO:0000313|EMBL:OQQ19386.1,
RC ECO:0000313|Proteomes:UP000192467};
RX PubMed=28326787; DOI=10.1021/acs.orglett.7b00545;
RA Wyche T.P., Ruzzini A.C., Beemelmanns C., Kim K.H., Klassen J.L., Cao S.,
RA Poulsen M., Bugni T.S., Currie C.R., Clardy J.;
RT "Linear Peptides Are the Major Products of a Biosynthetic Pathway That
RT Encodes for Cyclic Depsipeptides.";
RL Org. Lett. 19:1772-1775(2017).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQQ19386.1}.
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DR EMBL; MWFK01000001; OQQ19386.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V9KIU5; -.
DR STRING; 1955065.B0675_21665; -.
DR OrthoDB; 9808669at2; -.
DR Proteomes; UP000192467; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Reference proteome {ECO:0000313|Proteomes:UP000192467};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 2..416
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 422 AA; 44674 MW; 209DE0007B8D4766 CRC64;
MTRRVAVTGI GVVAPGGTGT KAFWDLLASG RTATRGITLF DPAGLRSRIA AECDFDPLAH
GLDPQLVRDA DRYIQFAVVA AGEAVRDAGI DTAEQDPWRV AVSLGSAVGG TTRLEHDYVK
VSEGGSRWDV DHRTADPQLH LAFSPSTLAS VVAEEFGAQG PVQTVSTGCT SGLDAVGYAF
HTIEEGRADI CIAGASDSPI SPITMACFDA IKATSPDNDD PEHASRPFDA HRNGFVMGEG
AAVLILEEYE HARARGAHIY CEIGGYATYG NAYHMTGLTS EGLEMSRAID TTLDQARLDP
TLIDYVNAHG SGTRQNDRHE TAAVKRSLGD HAYGTPMSSI KSMVGHSLGA IGAIEVVACV
LALKHQVVPP TANYETPDPE CDLDYVPRTA RPRKLRNVLS VGSGFGGFQS AVLLTGPEGR
TR
//
