ID   A0A1V9UG81_9PSED        Unreviewed;       267 AA.
AC   A0A1V9UG81;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=2,5-didehydrogluconate reductase B {ECO:0000313|EMBL:OQR28729.1};
GN   ORFNames=BWR59_20720 {ECO:0000313|EMBL:OQR28729.1};
OS   Pseudomonas sp. Bc-h.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=1943632 {ECO:0000313|EMBL:OQR28729.1, ECO:0000313|Proteomes:UP000192462};
RN   [1] {ECO:0000313|EMBL:OQR28729.1, ECO:0000313|Proteomes:UP000192462}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bc-h {ECO:0000313|EMBL:OQR28729.1,
RC   ECO:0000313|Proteomes:UP000192462};
RA   Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQR28729.1}.
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DR   EMBL; MUIN01000011; OQR28729.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V9UG81; -.
DR   STRING; 1943632.BWR59_20720; -.
DR   OrthoDB; 9804790at2; -.
DR   Proteomes; UP000192462; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR   GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR   CDD; cd19139; AKR_AKR3F2; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR   PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR   Pfam; PF00248; Aldo_ket_red; 2.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   4: Predicted;
FT   DOMAIN          8..184
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   DOMAIN          190..251
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        39
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         97
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            64
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   267 AA;  29335 MW;  1AC6D108554E8185 CRC64;
     MTVPAFGLGT FRLKDQVVID SVTTGFELGY RVVDTAQIYG NEAEVGQAIA QSGVPREDLF
     ITTKIWTDHY AADKLIPSLK ESLAKLRTDY VDLTLIHWPS PGGKVSVAEF MGALLEAKQQ
     GLTREIGVSN FTIALMKEAI AAVGAENIAT NQIELHPYLQ NRAVVGFAQQ QRIQITSYMT
     LAYGEVIKDP VIQQIAQRHN ATPAQVTLAW AMQLGYAVIP SSTKRENLES NLKAVDLKLS
     NEDMAQIARL DRGHRLTSPA SLAPQWD
//