ID A0A1V9XBZ1_9ACAR Unreviewed; 789 AA.
AC A0A1V9XBZ1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=[histone H3]-lysine(27) N-trimethyltransferase {ECO:0000256|ARBA:ARBA00012186};
DE EC=2.1.1.356 {ECO:0000256|ARBA:ARBA00012186};
GN ORFNames=BIW11_01575 {ECO:0000313|EMBL:OQR71039.1};
OS Tropilaelaps mercedesae.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Mesostigmata; Gamasina; Dermanyssoidea; Laelapidae;
OC Tropilaelaps.
OX NCBI_TaxID=418985 {ECO:0000313|EMBL:OQR71039.1, ECO:0000313|Proteomes:UP000192247};
RN [1] {ECO:0000313|EMBL:OQR71039.1, ECO:0000313|Proteomes:UP000192247}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wuxi-XJTLU {ECO:0000313|EMBL:OQR71039.1};
RX PubMed=28327890; DOI=10.1093/gigascience/gix008;
RA Dong X., Armstrong S.D., Xia D., Makepeace B.L., Darby A.C., Kadowaki T.;
RT "Draft genome of the honey bee ectoparasitic mite, Tropilaelaps mercedesae,
RT is shaped by the parasitic life history.";
RL Gigascience 6:1-17(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQR71039.1}.
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DR EMBL; MNPL01015526; OQR71039.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V9XBZ1; -.
DR STRING; 418985.A0A1V9XBZ1; -.
DR InParanoid; A0A1V9XBZ1; -.
DR OrthoDB; 902834at2759; -.
DR Proteomes; UP000192247; Unassembled WGS sequence.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR048358; EZH1/2_MCSS.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR Pfam; PF21358; Ezh2_MCSS; 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM01114; CXC; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:OQR71039.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000192247};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OQR71039.1}.
FT DOMAIN 547..648
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 655..770
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..371
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 789 AA; 88587 MW; 94DDB0B557E1D080 CRC64;
MEGRASRSQT NAAEREAKEA KGGSTVITRS ERKDAEAARV EIPGRIRRRV EQEYVKIRNA
HKEKRTRQII EKYSDNRRYV RETLEATRAS RKYGVKPQSV FPEMPAQGKL VKKVSVEVYS
GGSGGSSVRQ AVPCKLMTAV QAIPTMYTWA PTQQNFLVED ETVLHNIPYM GDDQDDSFIE
ELINNYDGKI HGDNDRKNTV NDERLIELVN ALMKYEDVAT MYTQKELEDN LSDPPEYLFA
CVHAVFPSLA GSPHDLLEKY RQLTGKGPKV PVGQCTPNID GPVALSVPRE QSMHSFKALF
CRRCYKYDCF LHSQGSVPQH KRRYYDMKVD SEPCGDKCYL HLSHVKEERA KEAKEAEEAK
EAREAREHQW DLAGGSEAAP GLIGADGTFL EGAIKIESRN LEQGITPGTA ALAHHPDSGN
EGSDDSNDAH IARDGLGQTR QKVTVNSLAT ESERAKQAPS SPQSELSARE SSEVWSAAEQ
SLFRVLSKPF YKNFCAMAAI MVTKTCAQVY TFAQNEPVDV APPPEDTDDD SRRAKKKKKH
KMWSTHSRKF AVKNAAGPGL ACQYSPCHHP GQPCDTTCPC VQLRNFCEKF CHCSPDCLHR
FPGCRCKAQC NTKQCPCYLA VRECDPDLCQ ACGADQLQVS NITCKNVCLQ RGLRKHLLMA
PSDIAGWGIF LKDAAAKNEF ISEYCGEIIS QDEADRRGKV YDKYMCSFLF NLNSDYVVDA
TRKGNKIRFA NHSIQPNCYA KVLMVNGDHR IGIFANRNIL PGEELFFDYR YGPTEQLKFV
GIEREIEYL
//
