ID A0A1V9XXY0_9ACAR Unreviewed; 1482 AA.
AC A0A1V9XXY0;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=CD109 antigen-like {ECO:0000313|EMBL:OQR78344.1};
GN ORFNames=BIW11_02748 {ECO:0000313|EMBL:OQR78344.1};
OS Tropilaelaps mercedesae.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Mesostigmata; Gamasina; Dermanyssoidea; Laelapidae;
OC Tropilaelaps.
OX NCBI_TaxID=418985 {ECO:0000313|EMBL:OQR78344.1, ECO:0000313|Proteomes:UP000192247};
RN [1] {ECO:0000313|EMBL:OQR78344.1, ECO:0000313|Proteomes:UP000192247}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wuxi-XJTLU {ECO:0000313|EMBL:OQR78344.1};
RX PubMed=28327890; DOI=10.1093/gigascience/gix008;
RA Dong X., Armstrong S.D., Xia D., Makepeace B.L., Darby A.C., Kadowaki T.;
RT "Draft genome of the honey bee ectoparasitic mite, Tropilaelaps mercedesae,
RT is shaped by the parasitic life history.";
RL Gigascience 6:1-17(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQR78344.1}.
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DR EMBL; MNPL01002353; OQR78344.1; -; Genomic_DNA.
DR STRING; 418985.A0A1V9XXY0; -.
DR InParanoid; A0A1V9XXY0; -.
DR OrthoDB; 2970602at2759; -.
DR Proteomes; UP000192247; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.2950; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF176; GH01829P-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000192247};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1482
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011963732"
FT DOMAIN 451..587
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 707..798
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1322..1411
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1482 AA; 166510 MW; FA10B4E8BBDAD6EF CRC64;
MPAPGGGLLL LAVVGLLIWA PQQIWCQSRR GVYTIVAPAI LRPNVVFNVA ASVGDVPNPV
DMRLSIQGND ERGQFNQITR TAQVTPVRTE LISFEIGDWS PGNYTLKAEG TGSIQFTNQT
ALSFVHKSYS VFIQTDKAIY KPGQRVQFRM IVTDPFLQPS VTGAIDAWVT DGKGNRIHSW
KRQFTTRGVL GNEFELSDSP VLGDWTLHCE VLGQKFSKSF QVAEYVLPTF QVKVELPKYV
TYNESDVVAT VKAAYTYGKP VKGWVTLTVT PRSRYQQIRP RPYEQFQKKV PIDGEANIPL
KATRDLQLKT DFFQREIEFF ALVEEEFTGR KYNTTSYMPI YDKPVRCELV KTSDTFKPGL
KYTAFLKVAY QDDTPVQDPE NQITFRYGYN YDEEHWTEQK HWIPSNGVIR LEFVPPNAPT
TVVLGMHAEY KGHIFYLESI MPAKSPSFSF IQARLLSPEN PRVGDRLEFE VSSTHPLDHI
SYQVMGRGDI VTGATLALRN ETTHRFGFTA SFKLAPKARL VVYTVGVNKE VVTDGVNFDV
SGILRTPVDV AVSARQTSPG SRVEVTVSTT PSSYVGILGV DQSVLLLRTG NDLSEKQVVQ
ELESYDAGKK AKMWPPYYRR RRRRSLWYPG SYTAGDLFKD AGMIVLTNGF IFEQDEAQFR
SELVDYSSET LPEHMAGEIA SYEPHLDSKF ADSLTDIVRL RKNFAETWLW KDHTSSSDGR
AVISEVIPDT ITSWVITAFA MDQATGLGIA PSPAKITTFR PFFVTVSLPY SVKRDESIAI
QCVVFNYGNK PIEADVTLDN TRKDFIFTSE ASKPDRKRVT VQPQNGTPVT FLITPTKLGY
IDIKVMASHS YGGDSISKKL LVQPEGSRQY FNKAILLERR NSQAAPSKYN VSVTFPKNSV
PQSEHVYLTA VGDILGPSVS NLRDLLKMPH GCGEQNMVDF VPNVVVLDYL NASKRLTPYL
ESQARRNIEH GYQKQLTYKH DDGSFSAFGN TDKSGSTWLT AFVVKSFAHA MEYISVDENV
LKNATKWLMQ QHLQDGSFRE PGQVVYKPMQ SAAGSGAALA SYVLIALSEA RERNNYPDQI
RQTEEYLLRE LRTTGDPYVT ALITYALHIS NNPNRDQAYS RLASLATRDD QHIYWKDPSV
THNITDYELH QTDLFFKRHF KDIEMTAYAL LTLVNRGDNS QAIPVMQWLI NQQNSNGGFT
STQDTVIAIE ALSRIAATVA SPTISIDVTV KFGEVGGSRT LRIESRNALT LQKLELPSEL
KWVEIEATGF GTAIIQVSWE FNLIVSSEEP AFYLNPLLDK TSTESYMQLS VCTHYRGEGN
ASNMAVMEVG LPSGYVFDYD TLSSIHRTND VRRVESYDGD TNVVIYFDRV TKNELCVTVP
AHREFAVAHQ KPVPVKIYDY YDLAKSARIF YHPKKARVCD ICTEDECSET CNDVDSQHEP
EFAIGQAVDP SSSLRASTPF AVAIVTLICI ALLRNENVNF FR
//
