ID A0A1V9XY55_9ACAR Unreviewed; 652 AA.
AC A0A1V9XY55;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 28-JUN-2023, entry version 26.
DE SubName: Full=Rap guanine nucleotide exchange factor 4-like {ECO:0000313|EMBL:OQR78399.1};
DE Flags: Fragment;
GN ORFNames=BIW11_06437 {ECO:0000313|EMBL:OQR78399.1};
OS Tropilaelaps mercedesae.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Mesostigmata; Gamasina; Dermanyssoidea; Laelapidae;
OC Tropilaelaps.
OX NCBI_TaxID=418985 {ECO:0000313|EMBL:OQR78399.1, ECO:0000313|Proteomes:UP000192247};
RN [1] {ECO:0000313|EMBL:OQR78399.1, ECO:0000313|Proteomes:UP000192247}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wuxi-XJTLU {ECO:0000313|EMBL:OQR78399.1};
RX PubMed=28327890; DOI=10.1093/gigascience/gix008;
RA Dong X., Armstrong S.D., Xia D., Makepeace B.L., Darby A.C., Kadowaki T.;
RT "Draft genome of the honey bee ectoparasitic mite, Tropilaelaps mercedesae,
RT is shaped by the parasitic life history.";
RL Gigascience 6:1-17(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQR78399.1}.
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DR EMBL; MNPL01002282; OQR78399.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V9XY55; -.
DR STRING; 418985.A0A1V9XY55; -.
DR InParanoid; A0A1V9XY55; -.
DR OrthoDB; 5473909at2759; -.
DR Proteomes; UP000192247; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113:SF327; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000192247}.
FT DOMAIN 74..226
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 302..382
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 407..650
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 20..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OQR78399.1"
SQ SEQUENCE 652 AA; 73552 MW; B378C97D0A8BCE37 CRC64;
DVEANTVRLK EHGQDVLVLQ KTGPQNQEAQ QGLPTGGASG PGGNSQLQTG PNGQQSNSPF
ASNQNNVVYN ASHYKYTVMA GTPQKMLEHL LETRIGERSD EQQVLLSSGG STSGADSFLE
DFLLTHIIFM PSHTLCPELM RHYRLDAVNQ RQEREFILAS KRRVVHFTAA WAGVVREPFY
QDPVVQGFLE ELLTALEEDQ IRYPGHSLVD QKAIVQRLFD IVDKYRTDPS HTSGQKWKVD
AYGQIRHLSS GSTQADDSTN QAGTNASGST QANNSGSGVA SSTSGNGTQH DQYHIRPFKE
DDEIIFRVYC ADHTYVTLKT PIGATADQIK RLAAEKTALN QEEAVLVEVK SNGERLPFNE
AEVSVATGLS INGRLFIVPI EHIDSLTPVT EQNLSMEGTA NILEALSSQD IAYHMAVYEW
KLFTTVHEYE LIYQVFGRHQ FRRSMSNLDV FQRRFNIVQF WVVTEMCLAN SLSRRVQLLK
KFIKIAQHCR EYQNLNALFA IVMGLGNQAV SRLSQTWERL PSKLRRTFEE LENLIEPSRN
HKRYRSAVAK LQPPLIPFMP LLLKDMTFCH LGNKTYIDGL VNFEKMHMIG QTLRHLRYAR
SQRLTIEHPH PQAASKSANH NDAVADYIRN LKVIDNQRTL SKLSLALEPR RS
//
