ID A0A1V9XZ54_9ACAR Unreviewed; 657 AA.
AC A0A1V9XZ54;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=sn-1-specific diacylglycerol lipase {ECO:0000256|ARBA:ARBA00026104};
DE EC=3.1.1.116 {ECO:0000256|ARBA:ARBA00026104};
GN ORFNames=BIW11_06217 {ECO:0000313|EMBL:OQR78732.1};
OS Tropilaelaps mercedesae.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Mesostigmata; Gamasina; Dermanyssoidea; Laelapidae;
OC Tropilaelaps.
OX NCBI_TaxID=418985 {ECO:0000313|EMBL:OQR78732.1, ECO:0000313|Proteomes:UP000192247};
RN [1] {ECO:0000313|EMBL:OQR78732.1, ECO:0000313|Proteomes:UP000192247}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wuxi-XJTLU {ECO:0000313|EMBL:OQR78732.1};
RX PubMed=28327890; DOI=10.1093/gigascience/gix008;
RA Dong X., Armstrong S.D., Xia D., Makepeace B.L., Darby A.C., Kadowaki T.;
RT "Draft genome of the honey bee ectoparasitic mite, Tropilaelaps mercedesae,
RT is shaped by the parasitic life history.";
RL Gigascience 6:1-17(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty
CC acid + H(+); Xref=Rhea:RHEA:33275, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17389, ChEBI:CHEBI:17815,
CC ChEBI:CHEBI:28868; EC=3.1.1.116;
CC Evidence={ECO:0000256|ARBA:ARBA00024531};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33276;
CC Evidence={ECO:0000256|ARBA:ARBA00024531};
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQR78732.1}.
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DR EMBL; MNPL01001875; OQR78732.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V9XZ54; -.
DR InParanoid; A0A1V9XZ54; -.
DR OrthoDB; 373802at2759; -.
DR Proteomes; UP000192247; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd00519; Lipase_3; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002921; Fungal_lipase-like.
DR PANTHER; PTHR45792; DIACYLGLYCEROL LIPASE HOMOLOG-RELATED; 1.
DR PANTHER; PTHR45792:SF8; DIACYLGLYCEROL LIPASE-ALPHA; 1.
DR Pfam; PF01764; Lipase_3; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000192247};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 79..177
FT /note="Fungal lipase-like"
FT /evidence="ECO:0000259|Pfam:PF01764"
FT REGION 468..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 657 AA; 70701 MW; 34E688720C550E1F CRC64;
MAMYLCRCIC CLWKRDADTG GANRSIVIED NCCLCNFAAL NQMLMKNNPN VQVIFVSYHV
NVNETPFLIA LDHERRTVVV SVRGTLSLQD IITDLNADGE LLPVDPPRVD WIGHQGMVKA
AEYIKSKLID DGLLNYAFSY SSDRGTSTYD LVLVGHSLGA GTAAVLSILL KKAYPNLWKI
IVGGMMCCSC GAELAEGDQL AAQMLHERSG LRHSESNITL NCSEPLFPPG KIIHIVRSHP
KNNLHPSGAP CPPGSGEGTP RMEKSMWRKL GFSSDEEPVY QALWTDPRDF DKVLVSPSMI
QDHMPDKVLE ALRKLLTKFG PAKPKRGVLA KTDILMSLHG ESLVLDPLAP MLPSGADPLA
PLETFEGEEH FAERVRALQR ARVVTEPPQA SGGGGSLSSL GLSLGGLSFK VPNSTGAPLA
SPETLSEVSS VSGFCADSRG RRSSVIERVH SDQLVTEQCD VPLYMKRDLV GSGRPSPNPE
EEKAPPSTCG EAATVEVGET TDDSLLLTPP TSILKAGHGG SPSISVSASS ATSRRSPAKK
VRISLGVPPS DDDDDDDDRG TSPLVRDSVA EPDDITNGDG VDAEAEVGWL ASCSSDSPTT
EDETQLTLED QMAVVRQPLP REQDYDSDVD ETASERSSSQ VSDSPLHSGQ DKRQKLL
//
