ID A0A1V9Y2P0_9ACAR Unreviewed; 2366 AA.
AC A0A1V9Y2P0;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=BIW11_05366 {ECO:0000313|EMBL:OQR79980.1};
OS Tropilaelaps mercedesae.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Mesostigmata; Gamasina; Dermanyssoidea; Laelapidae;
OC Tropilaelaps.
OX NCBI_TaxID=418985 {ECO:0000313|EMBL:OQR79980.1, ECO:0000313|Proteomes:UP000192247};
RN [1] {ECO:0000313|EMBL:OQR79980.1, ECO:0000313|Proteomes:UP000192247}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wuxi-XJTLU {ECO:0000313|EMBL:OQR79980.1};
RX PubMed=28327890; DOI=10.1093/gigascience/gix008;
RA Dong X., Armstrong S.D., Xia D., Makepeace B.L., Darby A.C., Kadowaki T.;
RT "Draft genome of the honey bee ectoparasitic mite, Tropilaelaps mercedesae,
RT is shaped by the parasitic life history.";
RL Gigascience 6:1-17(2017).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- SIMILARITY: Belongs to the PIH1 family.
CC {ECO:0000256|ARBA:ARBA00008511}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQR79980.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MNPL01000487; OQR79980.1; -; Genomic_DNA.
DR STRING; 418985.A0A1V9Y2P0; -.
DR InParanoid; A0A1V9Y2P0; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000192247; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR InterPro; IPR012981; PIH1_N.
DR InterPro; IPR041442; PIH1D1/2/3_CS-like.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 3.
DR Pfam; PF08190; PIH1; 1.
DR Pfam; PF18201; PIH1_CS; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OQR79980.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000192247};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1815..1987
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 2082..2350
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 1731..1752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2366 AA; 265991 MW; 0C0BFEDBCA42FC1D CRC64;
MAAFLDVPST SSGPSIILNL VPENEQSYEI RDMLDAAMSM ATEKSKPLTP AKGYCVKFRR
NDCDQKAFIN LCHTKEIPPP DDISEDELTR TLESDNPAAY RIPLSLGIPH DEQDKSGKPC
IAYDVIINTE FFHKVTKSEL FKTFVILLAV QGVEDKYSAK LSREDYVILQ NKKYWGTMPE
HYIQNRGTVK PAPLIDEIDP TPSSEPSVTT DGGVTTAAKT DPRVRLSRVQ KPGRTVEHLV
AEIMLADVRS VNELALDLAK DRILIHRNTS GKVEVDLYLP LELNVESARA QFDYKTRALR
IDAPILCSTM AGMERSFHLE AVKAQARNLA RMTPAPEEKL QYLLRQCPDL SHSNFTITRR
HQDSVIALGI YLLESGLSHK QLIVGYLLKL LHGLPKASWA DETTLSPDER LPPVERFSFL
LNTLLTDVMM QDEILQEEIL TAQIDLFQTL LNMVRGLQTS DSQGPGKPSQ GKITLCRVVV
PLILGAGRAF GRCHPEQKSI FLVIFPAPKA PSPIRVNPLM NTFPKSRRTF NSFRPIIPRS
LSELTSDTSN SLESHSLEEP QNFNLVSIDY DPTTYFFRKI GSSYSQLLPQ TNKTPLLVPI
SKCQTLLTLA KKLSKNDILS YMDAQATQVY EANDLRVFPY KSLSEVVNLV MLGLLQELLC
RNPRSGIPGQ FTKDVQEFVK AIFLAGQTEL QKESKDEEFN AVTLVVQSNA ACVDLLVWAE
LDDIGADSLC GRLSERICTP SAPRTVVAHL PLLLVCLEGL GKLAERFPNL VETSISALRD
FLITPSPILE KLYYVTQEST NKNQQAASEK SGAGALPMVS PAIKAAYERL RDTAIENICR
VLRVGLHEDA ECVQAFLASL SNRLYQAEKF RPGEAGLVAQ NTILTLGHVA VALKDTPKTS
NSILQFFQQK FNQPASSLDI LIVDQLGWMV IAKVEKHVFD AILKMFSLVT MESSSQQYNV
GTNEDHKQGY RHVSLAVINA LANIAASLQG EESMSELLSN LLELFVQLGL EGRRLSERQS
TLKASSSAGN LGVLIPVIAV LIRRMTPIVN PKPRLHKLFW DFWHYCVVMG FTSESGLWPS
EWYDGVREIA CKSPLIVSKE HLRSSLQYNS AIRSDTVSVG ELQELRNQTL KLLKTDLPFT
VDISAIVNKL NFAQCTYLMA VLRLETLRAQ NLLQGDCHLD YMFQYLEFPT IQKDKSSLWQ
CMMAVSDKVF LALLEVMLAK PKNKERDDEL ERYATFLLVK FNHPQKQIRR IADKYLAALV
DKFPHLLWSG KVLWTMLNIL HVLAKSLELD PNHLNPSLKV PGTKYLLSLT DTLEAREGIV
QDFAARCQGI IQEAMKWAPK VTRSHLEEYL SCSSAKAVFT QHSGVSLALE SVLRFAGLNS
YSAPLPSATL EKWPSCVKNN SSEFVCAIGL RSRFGGEITG LLQGADDFHR VRNDLANQLL
SKLRSSWETR SAALHMESVF RITALLIHTK GVDRSLLHAL CWTTVEFFAA DAMRATVACW
HWLLAARPDL ELVFLQEMSS AWLRTVALRM GIFSVDPEQP DPTRPQEGVV LEPRTPFVEP
HAIWVMFLSE RIETAKYSSS DQVEILADFF QRSLAATVVS RDEPRLTKHV GTIGTRFRFL
NSGLSLLQGD VLTSSIFRTM LRERIYCAAL DFFCGPQMCP TQSDADLRDD ISVLIKFWTS
VYQEKKYLKS RNSPDAWEAP PVDGRGSTDL LSRTTPTGWI NTVGMSSGMS TISRRSSAGR
TKDGQTGGVA GSSHSNMQLF AEDYIKKRNL ILWLLSFEIE FLSTWYNPMS APEKTIPNEN
VLQSWRAQAM AERNQRETTR LAWDISPTLA VYLPYRFKTQ ETIAQEVSSL VRQNPTMVAH
IPDALQFLAT PDSVTADGPD LNHVLTWAHV SPIKALAFMS KQFSPHPITA QYAARVLERC
PPDTIMLYIP QLLQAMRCDE IGYLFAHQLI WNIKTNLYMD EESTQKDELF EEFNALLESI
LEALSGPAKA FYEREFDFFS RITDISGHIR HFPKGAERKK ACLEALSQIV VQPGCYLPSN
PEAVVVDIDY NSGTPMQSAA KAPYLARFKV RHCGIAAMES HGMQQNSVAL AKVSSPMSED
DMAREYYQAA IFKVGDDVRQ DMLALQVISL FKNIFNQVGL DLFLFPYRVV ATAPGCGVIE
CVPQAKSRDQ LGRQTDIGLY EYFLKKYGEE TSPAFQEARY NFIVSMAAYS VVGFLLQIKD
RHNGNIMIDA MGHIIHIDFG FMFESSPGGN LGFEPDIKLT DEMVMIMGGK VDAPSFKWFI
ELCVRAYLAV RPYRDDIITL VHMMLETKLP CFRGQTIKLL RQRFSPLAQS EKEAANYMIK
VIRDSFLNFR TRTYDMIQFY QNQIPY
//
