ID A0A1V9YAA9_9STRA Unreviewed; 1289 AA.
AC A0A1V9YAA9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Ras-specific guanine nucleotide-releasing factor {ECO:0008006|Google:ProtNLM};
GN ORFNames=ACHHYP_15644 {ECO:0000313|EMBL:OQR82670.1};
OS Achlya hypogyna.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Achlya.
OX NCBI_TaxID=1202772 {ECO:0000313|EMBL:OQR82670.1, ECO:0000313|Proteomes:UP000243579};
RN [1] {ECO:0000313|EMBL:OQR82670.1, ECO:0000313|Proteomes:UP000243579}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 48635 {ECO:0000313|EMBL:OQR82670.1,
RC ECO:0000313|Proteomes:UP000243579};
RX PubMed=25527045; DOI=10.1093/gbe/evu276;
RA Misner I., Blouin N., Leonard G., Richards T.A., Lane C.E.;
RT "The secreted proteins of Achlya hypogyna and Thraustotheca clavata
RT identify the ancestral oomycete secretome and reveal gene acquisitions by
RT horizontal gene transfer.";
RL Genome Biol. Evol. 7:120-135(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQR82670.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JNBR01002425; OQR82670.1; -; Genomic_DNA.
DR STRING; 1202772.A0A1V9YAA9; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000243579; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000243579}.
FT DOMAIN 82..181
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REPEAT 674..706
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 707..739
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1012..1235
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1239..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1239..1253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1289 AA; 141374 MW; 6A4F519B82658755 CRC64;
MAACVGSSTG RDLLRDLWSF EEDEESAKKR LSGSSSCPRS PNPLLLIQTH DDSDSDDDIK
AYGGLDNGLR GLDLTVSPSA SMVLKEGWLV KRGHNWHTWK TRWFVLYRDA RLVYYKNPKL
RRVKGCVRLD DGIVKVQFAD TFQTKRPYCF QVVKGYYVLL CSSTSRTEAD AWVHALRRVR
SLSPSDTEGP VSLTSLVPNE AAVAATLASA QHARAIERQI ELFILRATTT VAGNNPLTPQ
ALLRFVSDLE TQIMQSIFLS SDATTRLAVR YYIEDKVFLP LIELFYAGLT RTVAAPSPAH
VQRLRNLPSH RLNPTDVDWS FAINSLSTLD TVSLPSHKLW VLMETIAWVA ETLRQAAPDA
DDAVLQRVLA YVVVHAAIDD LAGAAQLLQW THEHLPRCGH DADAVHLDAF ICALAWLQGY
TGAADTLAIA VTTLPFSTPE LGLQLSAIVG DRGARVAGIK KHSQASLCPA LCPDLVLLGI
NETLVAQWTL ADTVDCLRAA ALPKRLVFVS GTDYEKLVGS PDFDAYLACV AASRGDLPGL
LALVYEHSDG LLRRQCRWDR RHLVAGLPWL PPSHDTPLHA AVVGGHAAVV AELLDEFEVS
PVLVNAAGQT PLHVLRSHVP EIAPALVAVE PATLNAPDPR GCTPLMLQCS AGNVEGVVTL
LGLGADLRTV AWASGTTALA EAVVAGHADL VDLCLLRGAN VRHANLDGDT PLHLAARTCL
PRVIERLIAG GAVLTAQNRL GQSPAAVLLA HPPPTPKALL ECLALLATPA TLELADLWGR
HLVHIASQLP VGLKGAMELL LLRGANGHAV DLFGDTPREY RKHSKDHGAY VPPTAFMRHL
NVTLVQAAEA SPRLQLQSGR VEDLFTYLIA DKSMRLSEML AFVLNCNTYT EPTALLALLH
AKLTQNSKGL KKAWSVANFQ RDPCCGAAYF LVVTAYFFPT LVASAEFSCC WELVSSVPIA
TRVAALERYY RGPAPTPLYA DLYDHMTDMY GGKPQYTGCR PHLARLDVTT TRALDFARQC
TLVAHAVFAQ IPIRELLQPK CAHKGFLSAR HWFQHLSALV INYVLAEETP VDRARVVGFF
IDVAEICFES LQNFDTFVAI LYALQSTAIF RLKRTMANLP PATAAKLTKY QVYTQNGSRD
MNRVMKTVKP PCMPYLGLYL QNIVGLNELP KYEEESIVNF NRLRLLGSLA QDLLSYQSTP
FPITSSRKIE ELLHVDLAYT TDEARFDRSH AVESRSSIDA FEAESETPRR SSLSRDSIDS
TSSIFPRLRF SSFSSKRDRT SSASGLVWV
//
