UniProt: A0A1V9YH72

Database: UniProt
Entry: A0A1V9YH72_9STRA

LinkDB:  A0A1V9YH72_9STRA 
Original site:  A0A1V9YH72_9STRA

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Ontology (6)   
   GO (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (14)   
   InterPro (10)   
   Pfam (2)   
   PROSITE (1)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (23)   

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ID   A0A1V9YH72_9STRA        Unreviewed;      1451 AA.
AC   A0A1V9YH72;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=ACHHYP_12413 {ECO:0000313|EMBL:OQR85051.1};
OS   Achlya hypogyna.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Achlya.
OX   NCBI_TaxID=1202772 {ECO:0000313|EMBL:OQR85051.1, ECO:0000313|Proteomes:UP000243579};
RN   [1] {ECO:0000313|EMBL:OQR85051.1, ECO:0000313|Proteomes:UP000243579}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 48635 {ECO:0000313|EMBL:OQR85051.1,
RC   ECO:0000313|Proteomes:UP000243579};
RX   PubMed=25527045; DOI=10.1093/gbe/evu276;
RA   Misner I., Blouin N., Leonard G., Richards T.A., Lane C.E.;
RT   "The secreted proteins of Achlya hypogyna and Thraustotheca clavata
RT   identify the ancestral oomycete secretome and reveal gene acquisitions by
RT   horizontal gene transfer.";
RL   Genome Biol. Evol. 7:120-135(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQR85051.1}.
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DR   EMBL; JNBR01001827; OQR85051.1; -; Genomic_DNA.
DR   STRING; 1202772.A0A1V9YH72; -.
DR   OrthoDB; 211439at2759; -.
DR   Proteomes; UP000243579; Unassembled WGS sequence.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR   CDD; cd05778; DNA_polB_zeta_exo; 1.
DR   CDD; cd05534; POLBc_zeta; 1.
DR   Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR   Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR   Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR   Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR030559; PolZ_Rev3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR45812; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR   PANTHER; PTHR45812:SF1; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000243579};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN          607..789
FT                   /note="DNA-directed DNA polymerase family B exonuclease"
FT                   /evidence="ECO:0000259|Pfam:PF03104"
FT   DOMAIN          855..1300
FT                   /note="DNA-directed DNA polymerase family B
FT                   multifunctional"
FT                   /evidence="ECO:0000259|Pfam:PF00136"
FT   REGION          246..288
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          310..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          365..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1451 AA;  161179 MW;  93A7D175033D5776 CRC64;
     MEDDTVVRVE VVDVSYYLAK PLPVQAVKAL PEGPCYERAR QVPVVRVFGA TPEGPKCCLH
     VHGVFPYFYM RCENDPAFDD VATLMELLPT IGRDLEAALR SMATAPETDA QKAKTKPSKP
     IPPSIAKLVI VKGIPFYGYH ATEVFFVKVF FYDPAKTSRI VQAVESGHVA ARMFADYHIE
     GMNYLRVRDA TFRTQTGTST DWPVRQSNCA IEADVSCKNI LNPQFVNLDS DACYVPSLAP
     LWEEEKQRRR DQGLAATPEA APSIPRDALR RRHSEPDGSP SQSPLSQSHF NTRMWASLNE
     IIRQAASKHG NSEMLSNDGS ESPFPAGLDD SNFAYSQLDH APKDDEADAS DELLRLLSRL
     QEDRLREAVA PPSSPDAASD DEADDDHTDE AAAEERNAQA ILDSQRDFEL QSSQDVLPLE
     ECEKPTTAPA WWERDQSICE SQCSVDELGA PRILSPDRAA SQAAASFAAA DISPLSQSHG
     GRRYTWRYTV PAPKLDDLLP LPPSATPSVF YSNAADVPDK PVVYAGQRYA FPKPGVEHLP
     EFPSTHRALA ALKPPAPSTR IRRRRTPLRL PPTWQELQAT TGPASMPSPP TPTPAPVARP
     AHLHISNLTL LSVEVHASSR GELLPDPSFD AVEAIAMVVD TTFQQLQTRR YSLLVLDAAL
     ALTPLRLHGH DYAVEYVPTE RALLERFVER VAEWDPDFLV GFEIQVATYG YLIDRGAQLD
     PPINLIETLS RLPHTRMDSR NQALAEGNVG AAHGMKKAAG IWIYGRHILN VWRCARSELK
     LARYTFEAVV AHVLKRRFPK HAPATLSAWF IAGGSQRLRT LEHVGERADV TLQLVDRLQL
     VTRTSEMARL FGIDFFSVLS RGSQYRVEAV NIRVTKRLNY IMVSASRAQV AAQPPMEIIP
     LVMEPLSSFY AEPVVVLDFQ SLYPSMVIAY NLCYSTFIGR LVNGLDPALE TVLGVVADHR
     PNVDALRAAG GDTIVTPNGA LFCPKAHRLG VLPRVLDEIL STRIMIKQAM KQTTDKRLVK
     VLDARQLALK MIANVTYGYT AASFSGRMPC AQLADAIVHS GRVTLEAAVR LVESHPTWHA
     RVVYGDTDSL FVQLRGRSLR DAWAIGQEIA TAVTAANPKP VCLKLEKVYM GSFLVSKKRY
     VGLKFEGPDE VKGVLDAKGI ETVRRDSCGV VQKPMRRWLE LMFTKRDVSK GKAYLQQYWQ
     NMHHQRIPLR DFIFAKEVRL GTYAGQGPPA VLVATKAMAK DPRAEPRYAE RVAYVVVRGP
     PGARLMDLVV PPEELACHDK YTLNVDYYVT KQMLPSLERL ALLMGVNVRQ WYLELPRVVE
     KALPSLGASS VMRIDAYYAS QHCVLCGALN SRPRRLADGG WLCPACKHEP QKSFLLLQNY
     KSGLERQLLA ARSTCAQCMG STSHDADWTE RRHMVCVNDD CDVWNRWLRG AALLEACGDP
     MQLTANSHED G
//

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