ID A0A1V9YWA3_9STRA Unreviewed; 966 AA.
AC A0A1V9YWA3;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Protein HIRA {ECO:0000256|RuleBase:RU364014};
GN ORFNames=THRCLA_09472 {ECO:0000313|EMBL:OQR90005.1};
OS Thraustotheca clavata.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Thraustotheca.
OX NCBI_TaxID=74557 {ECO:0000313|EMBL:OQR90005.1, ECO:0000313|Proteomes:UP000243217};
RN [1] {ECO:0000313|EMBL:OQR90005.1, ECO:0000313|Proteomes:UP000243217}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34112 {ECO:0000313|EMBL:OQR90005.1,
RC ECO:0000313|Proteomes:UP000243217};
RX PubMed=25527045; DOI=10.1093/gbe/evu276;
RA Misner I., Blouin N., Leonard G., Richards T.A., Lane C.E.;
RT "The secreted proteins of Achlya hypogyna and Thraustotheca clavata
RT identify the ancestral oomycete secretome and reveal gene acquisitions by
RT horizontal gene transfer.";
RL Genome Biol. Evol. 7:120-135(2014).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQR90005.1}.
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DR EMBL; JNBS01002615; OQR90005.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V9YWA3; -.
DR STRING; 74557.A0A1V9YWA3; -.
DR OrthoDB; 5478541at2759; -.
DR Proteomes; UP000243217; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000243217};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 14..47
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 61..102
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 121..162
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 168..209
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 680..866
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 436..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 966 AA; 106256 MW; 68BC034F27E7C7D2 CRC64;
MLLEKPSEVR HSNAAGQDCA IYAIDAHPNQ LKVATGGGDT CVKIWSIVDK DGPCFELLAT
LAWHEKSVNC VRWSHSGKYL ASGSDDHSVF IYEFKEGAPS AVPFGSKQQP NKEKWERCAI
LKNHTMDVQD VAWSPDDRML ATCSIDNSIL IWSMDQITPV MTHPIQHLTG HNGWVKGVAW
DPVGKYLTSA GEDKSVIVWK VDTWEIEERI QTPFELCASS SHFRRLSWSP DGSLICATHA
HKSKQDVGAL VERKSWVNEV NFVGHRGVVT TARFNPRLLA KKSTNKEFTC CALGGDDCTV
SIWLADVARP LAVVKDCFDA SVTDLSWSHD GFTLFSSSLD GSICFFQFTA DELGTPITPQ
QQSRLLQQKY GSLAGLTSGS TLVEDPLQLE LEACEKSTGP TSTMDMLAKR ITPMGEASQV
LNQAPAPSVF TLTARPKSTT APEKDIATPK TTDNNEPQAP AANTLVPRPK PIAITNTENI
SPKTAQPPTI AVTEPTAVKA AQKALEPTTN TVKPTAPASE PTANSITTLV ARPKSKAPAT
TSAPPSSIQK DDDNAPIKRK RNLEVTPAAK ARSSMLVYSI ALVAGLLKFF CRVEADERED
VLAEISPRDV FNHTITLPRN KTRTLECRVS DDSCNITCTE AGDCLWMDRL PGHVVCMAGN
QSFCAFGTED GSLYIVSATG RRLFPCMALG HGFASIETSP NATPYLLVVL RNGAVKTWNV
LQPSLFIDTT LRSMVTFKST LIRSLVTDKG QPIVTMALSS GGRSRLHSFT FDLAMKCWMR
VADDHFSYSD FTTSVLTDTI VVASEVPVGP LRRLQNASSH ARNAKNMLDN FTNINLQRHV
TRTHLEQQLT SAIALQSRGE YKYWLVDLKG TFLSDDYCIR LKIYARYLAQ EGDVARLEEL
CTDLVGPMSA SSTTVNNPRQ TWQPLIMDMV KRDLLRTIVM PQMATNRILQ RLVTKYRVQL
DTHGST
//
