ID A0A1V9YX11_9STRA Unreviewed; 2720 AA.
AC A0A1V9YX11;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
DE Flags: Fragment;
GN ORFNames=THRCLA_09393 {ECO:0000313|EMBL:OQR90251.1};
OS Thraustotheca clavata.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Thraustotheca.
OX NCBI_TaxID=74557 {ECO:0000313|EMBL:OQR90251.1, ECO:0000313|Proteomes:UP000243217};
RN [1] {ECO:0000313|EMBL:OQR90251.1, ECO:0000313|Proteomes:UP000243217}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34112 {ECO:0000313|EMBL:OQR90251.1,
RC ECO:0000313|Proteomes:UP000243217};
RX PubMed=25527045; DOI=10.1093/gbe/evu276;
RA Misner I., Blouin N., Leonard G., Richards T.A., Lane C.E.;
RT "The secreted proteins of Achlya hypogyna and Thraustotheca clavata
RT identify the ancestral oomycete secretome and reveal gene acquisitions by
RT horizontal gene transfer.";
RL Genome Biol. Evol. 7:120-135(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the COX15/CtaA family.
CC {ECO:0000256|ARBA:ARBA00010773}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQR90251.1}.
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DR EMBL; JNBS01002567; OQR90251.1; -; Genomic_DNA.
DR STRING; 74557.A0A1V9YX11; -.
DR OrthoDB; 53593at2759; -.
DR Proteomes; UP000243217; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0016653; F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor; IEA:InterPro.
DR GO; GO:0006784; P:heme A biosynthetic process; IEA:InterPro.
DR CDD; cd20336; Rcat_RBR; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 9.
DR HAMAP; MF_01665; HemeA_synth_type2; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR003780; COX15/CtaA_fam.
DR InterPro; IPR023754; HemeA_Synthase_type2.
DR InterPro; IPR005821; Ion_trans_dom.
DR PANTHER; PTHR46586:SF3; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46586; ANKYRIN REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF13637; Ank_4; 2.
DR Pfam; PF02628; COX15-CtaA; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 19.
DR SUPFAM; SSF48403; Ankyrin repeat; 5.
DR SUPFAM; SSF140860; Pseudo ankyrin repeat-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 7.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000243217};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2422..2441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2461..2479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2491..2516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2528..2547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2586..2612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 1457..1489
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1490..1522
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1617..1649
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1686..1718
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1719..1744
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1967..1999
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2172..2199
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 2432..2623
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT NON_TER 2720
FT /evidence="ECO:0000313|EMBL:OQR90251.1"
SQ SEQUENCE 2720 AA; 306993 MW; 969CC072503128FD CRC64;
MLSRSRNAIR SSRLVHASIH QTVACPRVMG PTPKFMSSVA ATLENVAANR PIAYWLFGCA
GMVGTMVAVG GATRLTRSGL SMVTWKPHGG LPPMTTAEWE EEFELYKTFP EWQTRKNMTL
DEFKGIYFWE YSHRMLGRTI GLAFAGPLAY FVLKKRMPKE LYGRMAFLLG LGGFQGLVGW
WMVRSGLEDV DTANRKEIRV SPFRLATHLA LAFTTCGLLA WTGFSVLEPA LPERLNLERD
TITPDALKKM LRVRKALKHT TNILAFTILS GAFVAGIDAG MAFNTFPKMD DKWIPDGLFE
MEPKWRNFFE NTPLVQFDHR VLAMTTLAGF ATAYGLARHP QVWWQLPTPA KTALNLNIAA
VSGQVLLGIT TLLNCVPVPL AVAHQTGALV LLTSSVYTLH TLRFARPLSS VFHRIPKKPY
TWHFNYQSIM NTAIDTSSRQ CDICFDPVPL WDGVTQLCHT NCPAYLCMEC TETYFGQCLS
EFIPGILSKV HCPICVIPMP LTKCKAYATE DEVDYAETCL FASSEVRCPS CDNSTPFVQS
SSPIPPPLLL PSSLRQKIPW LRRLGTKFCR YKLTAAALYD YIAQKFTSHF HLTYQHVLHL
IHDPERRATF VLYHLHQIRQ VKTPCCKYQV CFECKSQGHS GECDVLSKPA YNSVVTCPLC
NIWIVRGDGC DSMKCVCSTY FSWNEQVLIA TQRKYDECLK SLFTRIHGRN AMIQVCNYLR
QLVWRRRRFR TVLYQFKVIC NKKTWIKVQV YLQNRILQRK LCRQNVLDEL TMKLKNGQLV
SKSKLMMHSS IPIASIAQLH IRTFSYYIRM AEPRSKVPRT VAYGNGNEFN VLLNTGLMDL
IQSFNDGKRL VDWTDGELAM KFGYLFLVIH AQKLEFPNEN AIDVAAAHGH LELVQWLHRN
PQFTWTGSPA AIDCAALGGY EDLVRWLVLN RSDGCTSEAL SNAAAGGHLN ILKFINEEYQ
DIPIPAGSYH EAAENGHVNV LKWLPWNFVK NDENGPSCLM DSAAKNGHIK VAEFLEKINA
VESMKAMDYA AEGGHLEMLK WLHERGYQSI STDAMNWAAN CGHLEVIKYL HEHREEGCTT
DAADFAAENA FLDILKWLFT NRSEGETAGA FDLAAKNGHL HIVEWLHANR GVGGTTAAMD
GAARRGNIKM LDWLRVHRTE GCSTNAMEFA AEKGHIDVLN WLQKHTTAGC TTDAMDSAAM
HNQLDALIWL HENRTEGCTA EAMAFAAEQG HLRIIQWLHE NRTEGCTTDA MDWAARNNHL
HVVHWLHDNR GEGCSADIVD VIIRAGHLRL LQWWYQHRRE RCTLNAIGLA CEYGHLPIVV
WLHEIGEKTT FKAMNLAAEG GYLHIVKWLH TNRTEGCSID AIEAVLTEEH PQIFKWLCIN
RTELKLSKCL KLTKELGSRA QVQWLKQFVQ TKKDLHKGNK ENKIAMDELN SLREADLVRW
TSKSKKSDVS SYRSAQKMEN MLHIAARRGF EAWTRILLEK SVNVNDQDAK GQTPLIVAIE
MNNFNVFQVL LDANTDLTLK TSSGQTAFAI AAHLKQTHMT QAMLPKLKDH GAMELFIALQ
EQSVDSLREL LDTGISPAIY RPDASQLPAL HATIDNELLL QVLLKKDASI VDMKDRLGQT
ALALAAMQGN LKACQTLIKF GANIDSRDIK GRSVGFLVAI HEQEEVLKYF LAQFPKSFSI
NTKDDEQRTP LHVHAENGNL SGCQLVVKYH AKLNALDAFG WTPMHLASSL GHMEVCAYLS
GQGALQLDCN DSAICKPLNI PSMWISVTYA RLCLIYNELF ECGLPQTIAK YGTLRIRDLE
MNTLLHLAAQ HVSMINADYL LKALQSTGSI PVNVHNCYNQ TPLHESQTKQ RHFNSTVLKS
MGSKDYTSLR GLLLQDQKLN EFNQCEPSKL SVLLSEISEG YCYLGDQSTQ CISSSDGNTV
LHALIETFKE KSPFPTVESQ IEILSSPNWL GSHEAGVEYL IEKTNWFGLT PLHIAASIGA
TGFCKVLVDH GANVSTECGP LDERLKDPGS IATEGWRALN FALESNASEE LVLYFLDQSN
SLPKTSAAIA HLKSAIANNY PILLPLLHHR LDDESKSNSV IMEATTRCEE FFQSNGHDEI
DNSAILLFKI VIEADLYGID ILKKYECKDL VIRPTGDTLL HVFVADTSRD RIPELAYLVT
QAKIPVNSTN NRRMTALHYA CKYHRVAIVS FLLGKGADIC AICYTSPSFS RQEPDILGAN
RIRKEDKKII SNNPAERAMW STPLQLCLSH KLEKLDPKQL QANSTIIEML LQYPESLMET
SARWDGSHLS DNALCHWNEF IFDKIATDFQ FALPLYLNHY MSSKVWYGTT TQTFYEVKQV
CQNLVRITQC DNSRVMLHPT VRNALRAKWK LFGRRIYRKE LCLAVLLLLF FTASNYKLAS
ENEAQNGSSN LSLSFDTADD CIAGIFKILA WLLALYHLVY VEIWQEWRLN TATYWRSWWN
YINFTSYLLL LLSIPMDLLN VPPSIKESCL SVASILLLFG LMQSLLVFSY FSVLLFTFSR
MLNVALKFCL LYTILLVGFT GAFYLIYHGS LGNTSLTESL ATVFFITFGE LNFRDNYASA
VNPYRYTFGL VIIVVYLICV NIVGINMLIA MMTSEYDVIK NRAEVLAVKE LASTLHRYES
WLGAKALEKV YESDELQSFT KHQFDTDRHA AFASKLENNK NPKNASKSLL DQLQNDLSRT
IERSEDAQAL KSQLNLVSKE
//
