ID A0A1V9Z2F2_9STRA Unreviewed; 1001 AA.
AC A0A1V9Z2F2;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=EamA domain-containing protein {ECO:0000259|Pfam:PF00892};
GN ORFNames=THRCLA_22397 {ECO:0000313|EMBL:OQR92215.1};
OS Thraustotheca clavata.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Thraustotheca.
OX NCBI_TaxID=74557 {ECO:0000313|EMBL:OQR92215.1, ECO:0000313|Proteomes:UP000243217};
RN [1] {ECO:0000313|EMBL:OQR92215.1, ECO:0000313|Proteomes:UP000243217}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34112 {ECO:0000313|EMBL:OQR92215.1,
RC ECO:0000313|Proteomes:UP000243217};
RX PubMed=25527045; DOI=10.1093/gbe/evu276;
RA Misner I., Blouin N., Leonard G., Richards T.A., Lane C.E.;
RT "The secreted proteins of Achlya hypogyna and Thraustotheca clavata
RT identify the ancestral oomycete secretome and reveal gene acquisitions by
RT horizontal gene transfer.";
RL Genome Biol. Evol. 7:120-135(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQR92215.1}.
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DR EMBL; JNBS01002347; OQR92215.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V9Z2F2; -.
DR OrthoDB; 5606996at2759; -.
DR Proteomes; UP000243217; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3730.20; -; 1.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR004626; RarD.
DR NCBIfam; TIGR00688; rarD; 2.
DR PANTHER; PTHR22911; ACYL-MALONYL CONDENSING ENZYME-RELATED; 1.
DR PANTHER; PTHR22911:SF137; PROTEIN RARD; 1.
DR Pfam; PF00892; EamA; 2.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 7.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000243217};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1001
FT /note="EamA domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012484024"
FT TRANSMEM 31..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 582..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 608..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..747
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 759..779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 785..808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 815..833
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 839..854
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 866..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 898..921
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 928..948
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 954..972
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 137..273
FT /note="EamA"
FT /evidence="ECO:0000259|Pfam:PF00892"
FT DOMAIN 695..829
FT /note="EamA"
FT /evidence="ECO:0000259|Pfam:PF00892"
SQ SEQUENCE 1001 AA; 110899 MW; 65381F82986EB47C CRC64;
MTLETAILFL VALIHLIVVD CQHTGAFLHV IVSLNLLLVG GGIVTVVTLL LFSAAVQLIP
LSLLGVLQYI APSLQFLLGV LVYDEPMSTK LIGFILVWIA LAIYTLEGLI CRREKKDDVV
IATPSGSGNS SISFEEIGIV YCVIAYIVWG VLPIYWKQLD VVPAEQLALH RIVWSFFFLL
VVLTVTKQWT TFLEQARGWR VFWIYSLAGV LILGNWMTYI WAVNAGYIVQ TSLGYFITPL
INVVVGVVIF KEKLRKWQWA AIVLALGGVL VVAIAYGKFP WVAITLGASF SVYGVVKKQA
PLNALHGLTY ETGVLFIPSV IYLVVVESTG SGVFLHISTA ATVLLIGAGI VTVIPLLLYS
SAAQSIPFSL LGMLQYIAPS LMFIMGVAVY HESFSTTKLI GFILVWIALI IYSAEGYIFQ
KKQPKINTVD SPRDRETAYE RNFSPRYFIT PMINVIVGVV IFKEKLRMWQ WVAIALALAG
VLVVAIAYGK FPWVAITLGV SFSIYGFVKK QAPLNALHGL TYETGVLFNP SMIYLVGKES
TGSGVLLCIS TTEIILLIGA GIVTVIPLLL YSSAAQSIPF SLLGMLQYIA PSIVFIMGIA
VYHESFSTTK LIGFILVWIA LIIYSAEGYI FQKKEPKTNI VDTPQDNRTA YECGFSICWF
IRDLLNCLPP LQNNWYVNLP FHIDCQYKIL AAMRTGILHC VGAMVFWGFM PMYWKQLEEV
PALELSLHRI VWALFFQVLG IVLTGRWSDF RKQISDWKVV GLYAIASVFI FANWLIDIWA
INAGYILQTS LGYFLMPLIS IVLGVLCFKE KPRAWQWLAI FLATSGVLVC AIAYGEFPWV
AISLALVFAF YGVAKKKAPL NAFYGLTLET AILFPPSLVY LIVLQATNKA ALGRVDLLHN
FLLVGSGICT IVPLVLFASA AQRISLSLLG MLQYIAPSII FIVGVVIYHE PFSIIKLVGF
ILVWIAVVLY SGEEFLHYKK QPKVVAVNSP NEHIDASFVG V
//
