ID A0A1V9Z3P0_9STRA Unreviewed; 819 AA.
AC A0A1V9Z3P0;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ACHHYP_03594 {ECO:0000313|EMBL:OQR92522.1};
OS Achlya hypogyna.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Achlya.
OX NCBI_TaxID=1202772 {ECO:0000313|EMBL:OQR92522.1, ECO:0000313|Proteomes:UP000243579};
RN [1] {ECO:0000313|EMBL:OQR92522.1, ECO:0000313|Proteomes:UP000243579}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 48635 {ECO:0000313|EMBL:OQR92522.1,
RC ECO:0000313|Proteomes:UP000243579};
RX PubMed=25527045; DOI=10.1093/gbe/evu276;
RA Misner I., Blouin N., Leonard G., Richards T.A., Lane C.E.;
RT "The secreted proteins of Achlya hypogyna and Thraustotheca clavata
RT identify the ancestral oomycete secretome and reveal gene acquisitions by
RT horizontal gene transfer.";
RL Genome Biol. Evol. 7:120-135(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQR92522.1}.
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DR EMBL; JNBR01000455; OQR92522.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V9Z3P0; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000243579; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF98; TO DEHYDRATION PROTEIN, PUTATIVE, EXPRESSED-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 2.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000243579};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 16..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 664..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..171
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 191..294
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 343..386
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 399..675
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
SQ SEQUENCE 819 AA; 91379 MW; 1E2095AEA9A7ED72 CRC64;
MTATGGHRVD TDPDEAILLS VEIYFSLFVV GFVAFELVRH RLAIYFNCRA ADPKASCPLA
EQEYGFGGWV LPVLRATDDE IMEFCGLDAL CYLRFLRLGR KVAGVSILLS LGLMPIYATA
VQPSTANTTT QDLVARLAMA NMNVSLDPNR LWAPVAAGIV VTVCTLRLLV AEYKVYVSRR
HEFLGRDGLQ QYTVLMNDLP SSLRTHEALA KYLYRLFPTM VDSVHMVMEC RELEAQVIKR
ARVRDDLERA MVLAVTTGRR PTTAFKRGQV DAIDHWTQLL EKLNVSIRTE IATLRGYQAK
LHESMNDDSL EDALCVSSLH DGSASSDSAP PAVSVATMLA FMRPSAFVTF NTLQATQSAL
QMLQTDSPTE LRVRPAPDPA DILWHNLGRT LDNVTSWQFA SSLATIAVIV LWSFPTAFVT
TLGAMQQWRD EYPAVERTLA AHPWLVDCAK QLAPLGLVAL SGLAPYVFGA LSRREGLASQ
TEVDAATFAK LVTFQFCQTF VVALLSGSLN SLLPVLVDSP YLFVTIFSEA LSLQASLYIC
YMAILIGLTL LFKLYRVGPF VVGLLYYIFA PRLTPRDRRS PWKWLSPMSA VETCSQSTIL
PSYFLVLLLV LVFCPITPLV AFFGGLFFFL SEVVYRRLYF FVYAPGRFTT GVYWPSMYRS
IVRALYMAQV ILIALLWVKV SDAWTNRVAV TSPGTVPASV FEEYAYWFAM APSVVVSFLP
FVTYVVDSRV CSLYLRAATF LPLVDCYRID AVRTGAMRVR SATAEQHRDN AMYVQPALQA
GSGLKTEFTF EQAQRLFALK RQPTGDHYEP LHEDVSEPI
//
