ID A0A1V9ZK52_9STRA Unreviewed; 553 AA.
AC A0A1V9ZK52;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Cathepsin B, cysteine protease family C01A {ECO:0000313|EMBL:OQR98372.1};
GN ORFNames=ACHHYP_08684 {ECO:0000313|EMBL:OQR98372.1};
OS Achlya hypogyna.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Achlya.
OX NCBI_TaxID=1202772 {ECO:0000313|EMBL:OQR98372.1, ECO:0000313|Proteomes:UP000243579};
RN [1] {ECO:0000313|EMBL:OQR98372.1, ECO:0000313|Proteomes:UP000243579}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 48635 {ECO:0000313|EMBL:OQR98372.1,
RC ECO:0000313|Proteomes:UP000243579};
RX PubMed=25527045; DOI=10.1093/gbe/evu276;
RA Misner I., Blouin N., Leonard G., Richards T.A., Lane C.E.;
RT "The secreted proteins of Achlya hypogyna and Thraustotheca clavata
RT identify the ancestral oomycete secretome and reveal gene acquisitions by
RT horizontal gene transfer.";
RL Genome Biol. Evol. 7:120-135(2014).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQR98372.1}.
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DR EMBL; JNBR01000085; OQR98372.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V9ZK52; -.
DR STRING; 1202772.A0A1V9ZK52; -.
DR OrthoDB; 5475703at2759; -.
DR Proteomes; UP000243579; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF679; PEPT_C1 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:OQR98372.1};
KW Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:OQR98372.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000243579};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT TRANSMEM 518..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 79..327
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT REGION 11..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 59731 MW; A5F3B956882E8925 CRC64;
MLISSALVAA HNHDHEGRQH HEAKHDHSKY KHGHDKHDSR KDKCCKRTMR GREHLHPHHA
DYKAPTVTPA QQHEIDNVLP SAFDWCEQGV CGPSWNQHIP QYCGSCYLHG SLSAAQDRIK
ILHAKKGFTG ADVMLGRQSF LNCAPGHNMS NGCDGGEAID VWRFMADYGL PDETCLPYNA
TDHTKFTWTN GTCPPEGYCM NCMYTPESPK VAQCFPVTKM VRYRAKEYGS LQGEHAMMKE
LLNGPITCGI ACSDGFSYNY SAGIFNDTTG FMDIDHDVEI VGWGEENGVK FWHIRNSWGT
YWGENGFFRI VRGTNNLGIE ADCTYVVPDV SQEDLVWSKS PAYGGSIWGI KPFSDAAKAH
PSVGDTLDVT GGEGTPPPTP APATSSTVGA PTTADPDSHA TCYVPIVEIT PTKPTMTATA
DHGPSRAHHK EYFTIVPCAS CANMVTEVAP PSPAPTTKQL TLSPTTADPP IPTPASTTQR
VPVTSVPTPA QSGSAADAQS TITASGTSSL ASSTALPSSV YVCLGLLTAI VAGLVLGRYT
LRQPRRGAYD IIN
//
