ID A0A1V9ZRG0_9STRA Unreviewed; 1480 AA.
AC A0A1V9ZRG0;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Nephrocystin-3 {ECO:0000256|ARBA:ARBA00040387};
GN ORFNames=THRCLA_05922 {ECO:0000313|EMBL:OQS00577.1};
OS Thraustotheca clavata.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Thraustotheca.
OX NCBI_TaxID=74557 {ECO:0000313|EMBL:OQS00577.1, ECO:0000313|Proteomes:UP000243217};
RN [1] {ECO:0000313|EMBL:OQS00577.1, ECO:0000313|Proteomes:UP000243217}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34112 {ECO:0000313|EMBL:OQS00577.1,
RC ECO:0000313|Proteomes:UP000243217};
RX PubMed=25527045; DOI=10.1093/gbe/evu276;
RA Misner I., Blouin N., Leonard G., Richards T.A., Lane C.E.;
RT "The secreted proteins of Achlya hypogyna and Thraustotheca clavata
RT identify the ancestral oomycete secretome and reveal gene acquisitions by
RT horizontal gene transfer.";
RL Genome Biol. Evol. 7:120-135(2014).
CC -!- SIMILARITY: Belongs to the BicC family.
CC {ECO:0000256|ARBA:ARBA00007662}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQS00577.1}.
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DR EMBL; JNBS01001695; OQS00577.1; -; Genomic_DNA.
DR STRING; 74557.A0A1V9ZRG0; -.
DR OrthoDB; 50780at2759; -.
DR Proteomes; UP000243217; Unassembled WGS sequence.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00105; KH-I; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR024983; CHAT_dom.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR049052; nSTAND1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR Pfam; PF12770; CHAT; 1.
DR Pfam; PF00013; KH_1; 1.
DR Pfam; PF20703; nSTAND1; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF13374; TPR_10; 1.
DR Pfam; PF13424; TPR_12; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00322; KH; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50084; KH_TYPE_1; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000243217};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 4..84
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REPEAT 1195..1228
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1428..1480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1428..1446
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1458..1480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1480 AA; 166921 MW; 191B4480EF5BC17C CRC64;
METWSKERVG EWLVKAGFTD LVQVFVENDI DGGTLLKERN WHHILFFVAL LPDLTNEILR
NELKINSFGK RSQLLAAIRQ IKERDNVLDL AVLHAAPLVL KTTHNDVPTV LAMEKLDLEA
ERLALQQALN SDFLGRIQLR FDVATADSFR TLLTTWKCKV LHFSGHGVGY NEMLCFEDGS
GCAHLITPKA LCELIYSGAI EASDYLQVVF VSSCHSERLA NVFVEAGVPH VVAVHSDSRI
LDSSGNTFAK HFYLSLFAGK SVLAAFDIAK TAVRALPPTN KRACCCAHLH ERTCRWALSG
MDHSKHPPNR CCCKGESLSW PHDESSKFLL LGQPQKSMHD VVVFPKLPRG KLIDLTPHCP
SNLPAMHGQF VGRNIDTYNL VRSVVKGNVT VCTGAPGIGK SSLVIAAAHY ILQRRICPDG
VFYIDLEGLA GLDFSAVLYA CFLAISTADA TLLYRYAIAR NVGLTLGENT THTQLFAELG
SKRCLLVLDK VEELLDKDRR NCEAFLGQLV ATAHHTRLLL GSRRIPNIPN VTVTSINIAE
LPLSIATNLI RSMALQCTQA EAEKLATICG KLPLALRVVG RALANSRARI TPQDLIERLQ
LEDHRLEEMN NLSEAGQKEC LDRCIRSSFT QLEWPLRLAF MAMGLFRGVF DLKAACAVLQ
SSYQSPTLLK SHSSPSVLLD TRSPFTPPSL SRTFNSANQL NSHSMLDDGT SSVKSLGSEL
YELDDYFDKD DALTSMSYSL LNLESEEEVV ASTCDVTQAI PALELLNQWS LVEKVMPMRN
TKMHPQQARY RLHNMIQLFA EDEATKFSNE TSEGEALFLS WRRRFVRHYC LVVANASHAF
RYEGLLLKFD SERSNIESAL RIAHQLSEHA EYVAREHQAS GVEESKYVPV VDVLLHSNLV
VRGRFIFRAR MDPRYRLKLF AKSIKLSRSA RVLNCHCKHP ENDSTILDAS DTMSQYEPTQ
TPKTIDACEC PGVMELLELE VLMLMEMGYA HFDVNEDPNA EHMYRESLRI QQEVLHRTDH
SYVAEAMNYL GIVLSTRRGF SPVNAWKFRK AESLLLQAKE IRERVLGPVH PDFATSLNNL
GNFYKSALAM IKDDAVTPGG LGYGGVLLKT NDEIRELYEK SLAIYKSHLV EDHPLVARSL
NNMALFLVHT YDKIPKAKLP SREKLTEVDK EIESLYKQAL EIRRKKLGNK NPETAATLNN
LGNLKYNQGE FTAAEAYLRE ALTIRQQYYT NTNDRVSTTM LNLGRILVAQ EKYKEAEMIY
REAQAIRETL MPNSREHGFC IEKIGRCMIK QGREEEGKKL VLEGQLMKRK CAFQSRNSTA
SNDIETESLA SESCTDTFKE HIFIHEYLSA EVISSSDFNV EGQIIGKQGI NLRRIEEQSG
AQVHFFSQKR HRDGESANFE FVATCEDAVA QAKSLTIEHL KDIQFRYDKR QSKPRQFKDP
NRRPPRHEDR RRHNRGRGNQ NANNAPSSMQ FSLEDLINKK
//
