ID A0A1V9ZX41_9STRA Unreviewed; 6274 AA.
AC A0A1V9ZX41;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Regulator of chromosome condensation (RCC1) {ECO:0000313|EMBL:OQS02576.1};
GN ORFNames=THRCLA_05068 {ECO:0000313|EMBL:OQS02576.1};
OS Thraustotheca clavata.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Thraustotheca.
OX NCBI_TaxID=74557 {ECO:0000313|EMBL:OQS02576.1, ECO:0000313|Proteomes:UP000243217};
RN [1] {ECO:0000313|EMBL:OQS02576.1, ECO:0000313|Proteomes:UP000243217}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34112 {ECO:0000313|EMBL:OQS02576.1,
RC ECO:0000313|Proteomes:UP000243217};
RX PubMed=25527045; DOI=10.1093/gbe/evu276;
RA Misner I., Blouin N., Leonard G., Richards T.A., Lane C.E.;
RT "The secreted proteins of Achlya hypogyna and Thraustotheca clavata
RT identify the ancestral oomycete secretome and reveal gene acquisitions by
RT horizontal gene transfer.";
RL Genome Biol. Evol. 7:120-135(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQS02576.1}.
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DR EMBL; JNBS01001111; OQS02576.1; -; Genomic_DNA.
DR STRING; 74557.A0A1V9ZX41; -.
DR OrthoDB; 52622at2759; -.
DR Proteomes; UP000243217; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00060; FHA; 1.
DR CDD; cd11709; SPRY; 1.
DR CDD; cd12885; SPRY_RanBP_like; 1.
DR CDD; cd14306; UBA_VP13D; 1.
DR Gene3D; 2.60.120.920; -; 4.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 4.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011498; Kelch_2.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR044736; Vid30/RanBPM/SPLA_SPRY.
DR InterPro; IPR041969; VP13D_UBA.
DR InterPro; IPR009291; Vps62.
DR PANTHER; PTHR22870; REGULATOR OF CHROMOSOME CONDENSATION; 1.
DR PANTHER; PTHR22870:SF437; X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR-RELATED; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF01344; Kelch_1; 1.
DR Pfam; PF07646; Kelch_2; 1.
DR Pfam; PF13418; Kelch_4; 2.
DR Pfam; PF00415; RCC1; 10.
DR Pfam; PF00622; SPRY; 3.
DR Pfam; PF06101; Vps62; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50188; B302_SPRY; 4.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 2.
DR PROSITE; PS50012; RCC1_3; 13.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000243217};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 289..340
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 341..395
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 396..448
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 449..500
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 501..551
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 552..603
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 604..658
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 634..834
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 2255..2448
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REPEAT 2993..3047
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3048..3101
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3102..3153
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3154..3208
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3209..3260
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3261..3316
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 4034..4088
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 5059..5261
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 5387..5574
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 5623..5654
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 5908..6260
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 3317..3338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3673..3703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3320..3334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 6223
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 6274 AA; 693160 MW; 57C4D5E3F355DE4B CRC64;
MGQAAVDDNF DEGKDTVAHL LDVGVDLSKL PPRNVDTDGW SAQEAQQLDV IVDAVDSING
LFGHISKLAS DLGMKKDGDV TSMDTTLPTS DFDVRLAKYV KNLTNLTTST KKEKHKYEQR
MLSVRNVSKS QRKVSPPPLP IPTQNCMVLG WDMAIQLMRA TRQEGGKTYL QALKMVQENI
ATLKPMVYLD GMYLAPSASN SFNLLCDFLI EAAEPIATNP IHIEQEICRQ TITVLAELAL
ARGSLSYLLS STLWMLSRHP NTEIDVNNLL TKLVAIKEQS LYGICEASGE LYCCGQNSYG
ELGIGDDIER HQLTFVPFGG WDDIRQVVSG NEILAILTNS GVVLTAGLNK SGQCGHGHFD
ERVMLLRPIE ALRSQRIRFL AASNGCEHII AITDTGLAYS WGYNDRGQLG HENLTTKIHL
PKLIDTLRDK KVTFAAVSYH HSALVSDKGE LYTFGMNDCG QLGHDTTQHQ SLPQVVKALD
GYVVTMVSCG LYHTIVCTAL GELFTFGKND YGQLGVGHNR QSKTPCLVSI PNEPICFVTC
GYYHSLVVGT SGRVFSFGRN DYGQLGIGTK VHQNVPHVIT LTPSLRITRA ACGCYHTVIL
SEQGHVFAFG RNNKGQLGNR GSTDSLLPVP LKVRPEKSSR RVLDIAAGFY TTSLIVERRK
ENEEDASSMD QSWVIPLCGR IDIDRSGEIE GLSNFGSLST IGVSLFRGKW FYEVEVVTSG
LIQIGWIDGY FQGSSDQGEG VGDHAHSWSY DGNRQRRWNS GSSTYGEKWK AGDIIGCLLD
LDASEMRFFR NGIDLGVAYT QFIINPLNLR SGMMPGISLE RGEIIRLNLG HTSFVFPPTR
EHESISKAIA YPATQVLLHP MALPNLHTAP EALHGSAKVL VGDRLFVIGG VLSHPSVLSE
GLKDGATNKV WVFNLKEKKW DRWSDLPIAL RFHQALLIDE HNILVIGGES DGAVSRHLDL
YKCSTVPNAD GSFPSWELVQ ATSTTSLPPS RAYHTVSAIR VRLETLVFLF GGRSSEDQIL
GDAWFLSLED YSWAKLPSSI ALDPGPRVGC LSCVVGESVY IFGGIDKEDR YRADLWRYNT
FDRVWHLCHD DYIHTPRENK TETKLPEFNP VIPVIRANHS LAADMGNIWL YGGENRKGES
FGDLWCFSLT RGTWSQVEVT SDEEIVGISH ASLFVEAGRV CSFESTSQSA ISLSESSCFL
YGGKCTAIVN GTQISKWETT IRCFTSSSSH KLHQISDNPR SSTSLIGKSS TVLSLLRSKH
PKAQCIPVCL DSASCILGHL DRLLGNDVPQ YDVDAIQPSR CSYRSLCIDA KESSFAALYR
ILSLLSKKYL WPEDAAMPSA DKLYPLLVVL RLIKFNFFEL STSCLVIDDL GFSPSSTENG
GTLFLMRELL FDIANYISPR SNSVEWDWFC AAIKKETVAA INCGFSIMFP SVIDRLLILT
RLFQDHSKTD VSDLLLPMLV PTFACPKTLF ELMGEPIFEN SNPNNDIEKY VQVSTNFAET
LLQSLWQATL SSMDSLTMLS SIEESLAFQS FNVLLRSAIS WASSSIHGWD IVKYLTRRLV
YYMTSLISHV RTASPCLVLQ HSFAGKQLPF ILISVLQLSS IRPIFATAIM DIWPDIEGLL
IALQNILRNT QSEGLSSSVS AQQNLTEEMK YSSVPLRVSP KLLEALQIPS NRVLTGAELS
SILWDAVRSL CSIRRLPSTV RDFELFRIVL PPPLAIVLSQ RSLTLGYCGS VSCEDLSSMA
FDDTKFTWKF AWTAITCHIA PVSTILQEVP LVATPTAEGD TEWVADLQSI LSYLGAQFAS
CLIKGELTAN QANPQIERWV FSSLFRGGLD EDNAKDDRNN QILSQILTNE GAGKKLVEKV
KLACDPGAIV NPKLRATRLK RQDSVERTLE KSGGFEAVDS AVRATFAVLI KHSHISYMSD
PVTRDGMPSD ALVDAWRTAL QLRRWIVREQ QKLAVSLSDS KTIVDENDDS DVTKERQQVL
YNQVCAPIIL RAKLLLELSP VPMPPSVSTN SSPFKILPGI SKTPFDFTKS ETPSIPADPE
QEQWLRQLNK LMETKSMEMI EEEDEKNQTD IFAFLQQPEG QSIDHEIQLL LKNHQQRALQ
RLQGLTIFFT LLKVTSSIPM ARFHLLPILA SSFVRVSSTN ERIKVHYSHE LELAGHKKIQ
EIATQYFTLM AYVLEGSSSS MLTLKNEYCG GNELKKPSVQ TMHQIVQDIL LALDSCSIPY
MGSDWQFIEH SCLPKFLSEL TSWQSWRDIF LIEDVDDAST NESDTQKSPV LAVGVGMSQV
IFYSGMDITV DSETHIISCL KKPSVPFAGT QISCDAGGMV MVQRVLSKGR WYWEILLRHH
GAYPVFIGVG SASVNVNLAY TSDNTVGVLV CKDKLTCNGP PLLVWPRGNP VGVLLDCDTK
TLEFFSGHKK IHSLSVQGLC HSGIGVYPIV GLVDCELQWD LYAPVPARIW SMIPKFTTPF
VAGGLTHDTF GGAALSWSGV LKGPHIQLSS DCSAIIAGDV MIASSVLETV VANKSFSDGH
LYLELTILAV GHKGKSLIVL GIVDTLFSGV HEGLLENGLL VEYDEFDCDQ DLIGVLFDFN
EGRITVYQKR KEPLVYMIDL SILDGSYVPA ISCSCNGTVI ATNFHPRARP QLPLSAIYPM
EKGTYATAAS SEKQVGKTLE FNVLSCDGGE FSVSHAVTNA LLDDNSVYSS SLGSNVNLVL
KHINDTPFTI TYVTMRGPGA GYTAPLQHAA IFILSSLPDL EELEQYSNLT PEEFAGLPSA
PTEARAKRDE TMPVMYFVLD GNCSQVSKRL VVPITGRYIV VKMLRPSLGM NIDVGYIGFC
GAFDKENGPA YSDLYWDDYM CIECHSSPVP GVCYVCDEDE TIKLCCVCYD DNRSNLERSY
YACVATEDEE RESTSSVLCP PRKLWSTTVM ALFDQSKPLA SLSGDNHVVV KTEPEDIYED
VELFACGQNN YGELCLGHCN STSKLEHVPL FTSKSVKQMT GGNEVLAVVM RDGVVYTCGL
NKSGQCGNGT FEERVVLATP VRALSGIPIT MVAASNGCEH MIAVAADGSA YSWGYNDRGQ
LGLGSTISKS HTPKLIESLH EKYFIITAGV SYHHSAVVTI NGELLTFGMN DCGQLGLDHT
QHQHTPQLVD ALSSQVVTKV SCGLYHTVVV TAGGDVYTCG KNDYGQLGLS HARSVKVPNH
MKLGPNESEE KVINSWSGYY HTTLITDKGK LITFGRNDYG QLGIGSKEHK NSPQVVPLPM
GSKVTSAACG CYHSLILLAN SRVMVFGRNN KGQLGAGART LPSADLPLPI PTSSYSEDDV
VAVAAGFYSS YILTGRRSDG CKKPQSKDEG TSKEGVSDQQ NVSCEALFES LMREMDRNAL
SEANDATSPL SLKRSNTSKK LPLLKLLSGA WAMTRALMYQ SLQVQLPKPT VNPVLKSFVL
SMLNNLAETV KSTDAVVGTA ENERFFSLAD ACVGLIKYCA SACSNGPVSQ LFSNQVLWVL
LLCGSVNSEV CSVIASSQVV LHEIVSGLMS TTLSSSIICL RLGMLLFPLT SVSAVNKVYR
SIVSPTNPPD IISFLFSVVG MPMVLRPQLC KHEMGIESTT TTLCKYFNCS KGVVVDGSML
LELNHVVKKH HINNAKACEA TALIRYLTLY PTWKKAVGAL ITRSLEKTDM VDELLQTIIK
FYDHFANSTE DKLAAEDKDE DQARQPEVAS ASPEVDENAV QTSVANAKKE RKIDVISESL
SFDKKAAALR KNAKEALDHA MLLLASICVV GGHTEVLREG GHVLFEDFEM RGRYKSGVLT
SLKKTTCGTV DGCITLAEES NQTTVPITSL QAVERIPAIP NMFDENLSDV LQSLSKLIIP
STMSPLEPKQ AFNPAIYSIL GNTIKSFKNQ IRWRSSKALS SILKQLPALD TSMSNNLDVA
IVSNIAALLA SENAFKISKL DDLPLLHNKW FCIREHQIYL AAENVIDSAL DSIEGHVRDE
VVRRLGDENA LSWGIDAIQS PKKRSSNFFQ AKPTSTDTKP EVPLGVWGML CPVQSAESID
APFISNFHLR SPVVRVGRAT DSCDIVINDR SVSGRHFHLR RARQGSADEY FELQDFSKNG
TIVNGVRVHG ASIQVTHGSR ISLILSRGGM VTYEFHVIPQ TSAPIHLDTA SEPQQTQQHE
FAEPRSPAEV QNRGMMNNIR ARLGPQGLRL ITTIGESDLP RALISPNPAM DSPRASSGAL
AVNPPPIAIS THSPRTPAVG SPASIPLAPH MLLSPASFQQ RESANTESSS PVAQRTEMAV
SEALRIALGR ESLNREGMQE MMQRTRVVTA SGDVVPAKKA TLPAPKPVGD TISTTDVARD
LYQRVRDLGG QHVELELCER ALQLHQGDVV RALKYVQESI SKSQSLGLSP QHRLAARSLA
HVLGQSTSLC SQALKQSNNN IGIALRSLLF NRSTYSHNEN DEDHRDDLVS DQFDKFVAQA
VDQLSSHDAT EENPSYSLLE TTAPNCVSPR RSIVRQSPVR KSIKICEEVM PWSTSNAHLD
SRIRTLNWHE VESEEEQLGQ VLCAAHARKL LLQVIRLLQP HQNRVDESSP LYSFGDRSTL
RQLVLFPENT PGEESLDEQS HHRHTQGRIQ QILARISSDV MNSSCNQTLE TNMRVFQNVS
TLASSIDKTD QLLASHANHN TIHEVVRTLL SSELTSERPI CEDLVMDTMM HVISKTFSAK
CEYDGRRETE YPKGPFLVSS GLEVTIVATY ERCWSIPHPD PLLVYRHKWR KKVPLDKESR
AAFDCGMTLW RPVFPASFKS TLVAPEKWFA LSDVVKAGSD APTTPIALVR DNEDGCVAPP
LRFECVDVSG KGLPKNSEID SEFERKQLRS MWYPIAPPGY VAMGCFAGNK ESPYDPPPVE
TCRCVRQDLV QFIDIASCVW QTPSVSLWNV ASDYSHHILP TSEQLQEATQ APVLLLTEDD
RILCSPVTTA TVLRFINVIL HANQFVQGKS ILAPELTSAL FVLVKQALGE KRSTSVSIEL
VRALATLVRH GCPWRDKEGV LYCRSKVMFL HQDQEGSLML SALLQALVEL LLVVENQNRV
ERLEIFRQMP VYETTATLPY TFTKEPTAHS FSHAQSSRIR IDPVDEKLSE WSVSFTEPSD
ASKADDFGSL RYDHTSILEI FMEKCKIAVL SYFEVTILDS KPSPSKTPGF SLGYSMGDFV
LDGICVGVQA KSYSFTPSTG KIQAGDPLVD VWSWHDSANA TNIGDVFGCG LRLDTHEIFF
TKNGKLLGTA FSSILGDDQL QPTISLDSEM LLRVRIGAQA TFAFPMDTTD WDAPMSGFDW
FEHLSQVYSI MNSLVNRKPL PDEFMLSADN FLSTLSKDVC KTFESKHPYE LDLQEETVHI
ALATSIRIKL DSNCETSGSH CLQIAQGSDE TAESEVRTFT GSCGGQEITV DGNEFTWRFP
VQSNFQCRID RVRKGPYIKL ENRDTRLSLT RDKGWQTAIG VARFDSGIHT WEVKISFVTA
SSNIFLGIAR KDVRFDSYLG KDNRGWGWIG NRALWHNGSK QRGTYGEKFK TGDVVRLILD
LKRGTLSYAL NGKDLGVAFG PGGTGPKLEG TFYPGFALYN QRDIVELVGG HRMEDSDISP
VALPGSIPVD ESGEIYGSDD EDGDVEGSVE AVPNYRVELA TVLSQMGFPM DWCVYALKHC
DDDAEQAADF ILSNMHAMES LVREEAEAYS RMLAAREEVA MLTTSAVTEV ELPTTETEAP
PIDNEPQALA NIEKWGISFT VVPEFSVAGR HLLAFKYAKE LTSLHNAHRL FTLEHDEAIV
TLVNDMCEAR AEASIACDPL RLRPEEFTPS QDALREYPCL ASLALESLQS RFLVLRNFNS
RLQHVLSFID FSALDSTLTK CLRELRGCVF QSVKLAWWFS ILKEQQTPAA ARPEIEVDRH
RAAECTNDKM GVVDSVFTQC FNQLQTLQGS LLRGHDRAFK CQFVGEFGDD FGGLYRECLA
QMSTELQSPI LPLLKPCPNQ VLQMGENREF FVPNIHLRND PKLIQMAEFL GKIMGIAIRS
KTPLDLNLPP VVWKFLVDQR ITRYDIESIH NGCFQVVDTI NNITKHGITR SMFDDLIDAS
FTVLSSDRKE VELVPGGRLV RLTWDDKDEY AMAAEAYRLT EFQPVCTDIA RGLSTILPVP
TLSLLTWRDL SVLTCGKATV DIDLLKRRTT YGDGCAATDA HIAYFWEVLK ELSDAQKALF
LRFVWGRSRL PTHAADFTQD FKISGMPKAV GKPDAYLPLA HTCFFSIDMP AYTSKAVMKE
KLLYAITHCT AIDADNTTVA QRAGQGLNWT RTSD
//