ID   A0A1V9ZXG2_9STRA        Unreviewed;      1163 AA.
AC   A0A1V9ZXG2;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   13-SEP-2023, entry version 18.
DE   RecName: Full=CRAL-TRIO domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=THRCLA_04949 {ECO:0000313|EMBL:OQS02694.1};
OS   Thraustotheca clavata.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Thraustotheca.
OX   NCBI_TaxID=74557 {ECO:0000313|EMBL:OQS02694.1, ECO:0000313|Proteomes:UP000243217};
RN   [1] {ECO:0000313|EMBL:OQS02694.1, ECO:0000313|Proteomes:UP000243217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 34112 {ECO:0000313|EMBL:OQS02694.1,
RC   ECO:0000313|Proteomes:UP000243217};
RX   PubMed=25527045; DOI=10.1093/gbe/evu276;
RA   Misner I., Blouin N., Leonard G., Richards T.A., Lane C.E.;
RT   "The secreted proteins of Achlya hypogyna and Thraustotheca clavata
RT   identify the ancestral oomycete secretome and reveal gene acquisitions by
RT   horizontal gene transfer.";
RL   Genome Biol. Evol. 7:120-135(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQS02694.1}.
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DR   EMBL; JNBS01001091; OQS02694.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V9ZXG2; -.
DR   OrthoDB; 50936at2759; -.
DR   Proteomes; UP000243217; Unassembled WGS sequence.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd04371; DEP; 1.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45824; GH16843P; 1.
DR   PANTHER; PTHR45824:SF6; GH16843P; 1.
DR   Pfam; PF00650; CRAL_TRIO; 2.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00049; DEP; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00516; SEC14; 2.
DR   SUPFAM; SSF52087; CRAL/TRIO domain; 2.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 2.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000243217}.
FT   DOMAIN          1..98
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          145..197
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          583..730
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
FT   DOMAIN          973..1134
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
SQ   SEQUENCE   1163 AA;  132209 MW;  4CF904025BBBE33B CRC64;
     MRGKVLLRAS EYQWISRIME LDSDALLFYE DTGKPTTLES VDLIGATCEV VVVSSEHLHC
     FRVVEVDAET KSTKEWILDA RSSQDKQNWI SSIQTTILNL KKTTRVPAPI VDIDASNGID
     RKRIDAARRL VHDLQAQRGS LFLRGKDVLD ILQKHVGCNS RTEALILGNT LLNEGFFKHM
     VSQYTLLDDD CLFETVSRTQ YNLHRQFHYQ RQDDDNIGSD DDDDEAQVAH LNQTNGYYCP
     ELHNLFVSML IEIEIFYIVE DPRPNESMSV SAVDLDLDFS SFDASKELTL KECFYGDDAV
     TCLMSVGLLN EEAALVLGNQ LLARGYFSPM DSETISFENA RTRYVLSPDV TRSIAPTAEE
     TIMDLQYQEE KYRNDLKSAM DMRHQGMQWL CISMGALLLF DSLQEMSLLY KIVFVAISWL
     GKFFLHDPHA SIPDQVPAIG QYTKLLRVKK NNAPPPVETM MSDNETRIRS ASAAALRQRF
     PKTSETTTPS KETTAVVSKT IASLSDEDRA RLETFKKMLT FDANSAFLFT DEYLFSVMNV
     KNRTMNYAAE KLLRCIAWRQ DYGAGSITAN EVMGQFLGCS MYWYGYDYAN RPIFWARPKR
     KNWAKMNAAI EIRAHVFMIE LGVKCMMPPG CTTFTFVTDC ANVGYREVDI RLMKGLMEVC
     SGNYPDRIGS ICIGPLTTLV KTLTRMLAPL LPARLREKAK FMRSPGKELE EFMPPEYIPT
     FMGGKATHIL NPHGQPDVFD FNYMLESQKE RMKHLPKKTN TESSVIHRFI LGMAMTSKGH
     EGMRWLAMSF LVILFLDSLA EVSFVQKIVL VVWCFFGKVY LFDFQSVEVM HPIKHLPTPR
     QVHLPKKKIE IKQEIIVPPL SVVEEVESTG KSMERTPSMA STVSTYCDSP PLSPASNNEE
     VDAFDVGLNG EDLKRVQTFR NMLNITEDAE FLFTDDYLHC VLSVPNRTVE YAAEKLNRVI
     AWRTEYKAST ITAEQVAPQL RTGSMYWYGY DHNNRPILWL RPKLKDWSTM DKELEIQAHV
     FMLELAIKEL MPPGVTSFTL VTDCANVGYR DVDIRLTKGM IQVCQGNYPD RIDNICIGPL
     TMLVKTLTKV ISPLLPKRLR DKAHFMDSPA TDLAKIMPAN LIPTYLGGTA THSLNSNGDS
     KQFDFNYLLA SQKERLQSVI QTS
//