ID A0A1W0B4V1_9NOCA Unreviewed; 1918 AA.
AC A0A1W0B4V1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ONM45992.1};
DE Flags: Fragment;
GN ORFNames=B0T46_25410 {ECO:0000313|EMBL:ONM45992.1};
OS Nocardia donostiensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1538463 {ECO:0000313|EMBL:ONM45992.1, ECO:0000313|Proteomes:UP000188836};
RN [1] {ECO:0000313|EMBL:ONM45992.1, ECO:0000313|Proteomes:UP000188836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=X1655 {ECO:0000313|EMBL:ONM45992.1,
RC ECO:0000313|Proteomes:UP000188836};
RX PubMed=26914251; DOI=10.1007/s10482-016-0667-8;
RA Ercibengoa M., Bell M., Marimon J.M., Humrighouse B., Klenk H.P.,
RA Potter G., Perez-Trallero E.;
RT "Nocardia donostiensis sp. nov., isolated from human respiratory
RT specimens.";
RL Antonie Van Leeuwenhoek 109:653-660(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ONM45992.1}.
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DR EMBL; MUMY01000038; ONM45992.1; -; Genomic_DNA.
DR STRING; 1538463.B0T36_25625; -.
DR OrthoDB; 4516163at2; -.
DR Proteomes; UP000188836; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 3.40.50.11460; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000188836};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 34..447
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1720..1795
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1811..1918
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1391..1427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1918
FT /evidence="ECO:0000313|EMBL:ONM45992.1"
SQ SEQUENCE 1918 AA; 200553 MW; A691EFA4AAF1DD90 CRC64;
MSVSSEALLE ALRVAARDNA VLRQTHDRLL AELSEPIAII GMACRFPGEV TTPEQLWRLV
SEGRDAIGPF PEDRGWDVAG LYDPDPDADG KSYVRHGGFL YDAAEFDAGF FGISPREAVT
MDSQQRLLLE TVWEALEDAA IDPYTLRGSD TGVFAGVMYH DYPFSAGSGS IVSGRVAYTL
GLEGPAVSVD TACSSSLVAL HQAVRSLRAG DCAMALVGGV TVMATPDTFV GLSRQRVLAA
DGRCKSFAES ADGTGWGEGA GVLVVERLSR ARELGHEVLA VVRGSAVNSD GASNGLTAPN
GPSQQRVIGR ALASAGVGAG DVDVVEAHGT GTVLGDPIEA QALIATYGQD RAPESPLWLG
SIKSNIGHTQ AAAGVAGVIK MVQAMRHEML PRTLHVDAPT PHVDWSGGAV RLLTEQQPWP
RREDRPRRAG VSSFGISGTN AHVILEEAPP PPPPIDSTDT APVQDSDATP AIRGTVAWVL
SARDRTALAE QARRLIEHLR SRPDDTPTAI GWSLVSGRAR LEQRTVVLGT GRDDLLAKLA
VIAADPATAI VSGAPSAPVP TGARARGRTV FVFPGQGTQW VGMGRELLDS APVFAATIAA
CEVTLTDRVP WSLTAILRAP DDDPTAAALL ERIEVLQPVL FAVMVGVARV WEALGVRPDA
VVGHSQGELA AAAVAGALSV DDALRIVLER SRLFAEKLTG RGAIASLGMP ADTATEQLAR
YPGLTLAGVN GPAAVSVAGE LPELDRLVTD LTAAGVRARL IATTVASHSA AVEPLRDELI
GALSFVRPQR ARIPIYSTVT AAEIDGTELN ARYWYDNCRQ PVRFQDTVRA LRSDGFGIFV
ETGPHPVLTM PVEQTVAEVD GPEAIVVGSL RRGDGSARQL LDTAARLFVA GAPVDWSALY
HGREPRRIPL PTYPFQRRRY WLEPTGAGSA AAALGQWEAD HPLLRAVVAA PDSGGVTITG
RLSLRTHPWL ADHAFAGTVL FPATGFLELA LRAGDETGSP VVDELNLLQP LLLPDDRTIR
LQTVVGGPDE HGRRPVSVYS SADGEPGGIW VRHAEGRLTP HLAVDGPESG TQWPPAGFAP
ADIDGVYEDL ADAGYGYGPV FQGLRAVWRR DTDLCAEVAL PDTVTDAERY AVHPALLDAV
LHALGAVTDP ATGAGPVLPF SWAGVTAQLH GATALRAEIT SAETDAISLR VTDMQGHPVL
SVRSLTTRPV PLDRLTSPQQ PLLTVAWRGL PHAAAPETEV RYEPWARCAN QNDTAAPVVV
LDCRWHDGRT VIAETHAATA NVLAVLQTFT GSARFTTSRL LVITHGAVSV AGEDIGDLAA
TAVWGLVRSA QSEEPGRIVL LDTDTGEPSV ASIAAVLACG EPQLALRGET LYVPRLTRLP
GIDTTPLVGG TAPSVGGTAP SVGGTASPVG GATPSVGGTA PSVGDIASPA TDTAPALAAD
ATVLVTGGTG GLGAAVARHL VAAYDVRSLV LASRRGPAAP GATALVDELS AAGARVRVVA
CDVSDRAAVA DLIAAVPADN PLGGIVHAAG VLDDGVIGSL TPQRLDTVLA AKADAAWYLH
ECTQDRDLAM FVLFSSAAAV FGSPGQGNYA AANLFLDALA AHRHATGAVA TSIGWGLWTT
VTDATAHLDA ADTARIRRGG ITGLSAEQGL ALFDAAVRQP QPAVTAVRLD RMVLAEQARA
GLLPPLLREL APAARQNGSS GGSGALARRL AEADNRDRTQ LLLDLVRAQV AVVLGHDGPA
AVETERNFQE LGFDSLTAVE VRNRLAAVTE LALPATLVFD HPTPLAVARY LQDRLLGTVV
RTEPVARAAT SEPIAIVGVG CRFPGGVDGP EALWRLVTDG GDTLSEFPSD RGWEVEKIYD
PDPDPDAVGR SYVRHGGFLS GAGGFDAGFF GVSPREAVVM DPQQRVLLEV VWEALEDA
//
