ID A0A1W0VUT7_SORBI Unreviewed; 663 AA.
AC A0A1W0VUT7;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN ORFNames=SORBI_3010G253500 {ECO:0000313|EMBL:OQU77014.1};
OS Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum.
OX NCBI_TaxID=4558 {ECO:0000313|EMBL:OQU77014.1, ECO:0000313|Proteomes:UP000000768};
RN [1] {ECO:0000313|EMBL:OQU77014.1, ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=19189423; DOI=10.1038/nature07723;
RA Paterson A.H., Bowers J.E., Bruggmann R., Dubchak I., Grimwood J.,
RA Gundlach H., Haberer G., Hellsten U., Mitros T., Poliakov A., Schmutz J.,
RA Spannagl M., Tang H., Wang X., Wicker T., Bharti A.K., Chapman J.,
RA Feltus F.A., Gowik U., Grigoriev I.V., Lyons E., Maher C.A., Martis M.,
RA Narechania A., Otillar R.P., Penning B.W., Salamov A.A., Wang Y., Zhang L.,
RA Carpita N.C., Freeling M., Gingle A.R., Hash C.T., Keller B., Klein P.,
RA Kresovich S., McCann M.C., Ming R., Peterson D.G., Mehboob-ur-Rahman,
RA Ware D., Westhoff P., Mayer K.F., Messing J., Rokhsar D.S.;
RT "The Sorghum bicolor genome and the diversification of grasses.";
RL Nature 457:551-556(2009).
RN [2] {ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=29161754; DOI=10.1111/tpj.13781;
RA McCormick R.F., Truong S.K., Sreedasyam A., Jenkins J., Shu S., Sims D.,
RA Kennedy M., Amirebrahimi M., Weers B.D., McKinley B., Mattison A.,
RA Morishige D.T., Grimwood J., Schmutz J., Mullet J.E.;
RT "The Sorghum bicolor reference genome: improved assembly, gene annotations,
RT a transcriptome atlas, and signatures of genome organization.";
RL Plant J. 93:338-354(2018).
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
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DR EMBL; CM000769; OQU77014.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W0VUT7; -.
DR STRING; 4558.A0A1W0VUT7; -.
DR EnsemblPlants; OQU77014; OQU77014; SORBI_3010G253500.
DR Gramene; OQU77014; OQU77014; SORBI_3010G253500.
DR InParanoid; A0A1W0VUT7; -.
DR Proteomes; UP000000768; Chromosome 10.
DR ExpressionAtlas; A0A1W0VUT7; baseline and differential.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11764:SF64; TERPENE CYCLASE_MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU362003};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000768};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 58..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..160
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 325..655
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 663 AA; 76262 MW; 2E4089DB8518EC38 CRC64;
MQYAKLNQRL HPSTPSMKLE NSEEVTEEIL LTSLRRALSQ HSTLQAHDGH WPGEYSGLLI
IMPMFIFSLY VTGSINTIIS LEHRREILRY IYNHQNEDGG WSTHVLRTST MLGSCLNYAA
LRLLGEVAHG ENDALSKGQA WILSHGSATA LPQWGKIWLS DDSIAFSGWY ICQWHIFMGR
NLFWPITPIV LALREELYNI PYDNINWKEA RHSCSKEDLL YPRSQVQNII FTCLNKFVEP
MLNCWPINKL RERALHNLME HIHYEDETTK YICLCPVNKV LNMICCWVEN QNSDAFKKHL
PRIYDYLWLA EDGMKAQVYN GCQSWETILT VYAFCSTNLI DEFGPTIERA HEYIKRSQVL
KDQPNYQSYY RQRSKGSWTL STVDSGWNSP DITAEALKVL ILLSKISPDL VGNPIEEQKL
YDAVDCILYS MNKGGTFSSY ECQRTTSWLE ILNPSENFVN IVIDYPYVEC TSSVLEAFIL
FKELYPLYRT QEIDECINNA AMFIENKQRK DGSWHGTWGI CFTCGTMFAV KGLVAAGRTY
DTSSSIRKAC NFLLSKQQTT GGWGESYLSS ETGKYSNGDT HAVNTAWAML SLIYAGQVER
DPIPLYQAAR ELINMQLDTG DFPQQEHIGC FNSNFYLNYA NYRNLYPIWA LGEFHHRLGA
NKN
//
