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Database: UniProt
Entry: A0A1W0WEE5_HYPDU
LinkDB: A0A1W0WEE5_HYPDU
Original site: A0A1W0WEE5_HYPDU 
ID   A0A1W0WEE5_HYPDU        Unreviewed;       564 AA.
AC   A0A1W0WEE5;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   31-JUL-2019, entry version 13.
DE   SubName: Full=ATP-sensitive inward rectifier potassium channel 12 {ECO:0000313|EMBL:OQV13584.1};
GN   ORFNames=BV898_12221 {ECO:0000313|EMBL:OQV13584.1};
OS   Hypsibius dujardini (Water bear) (Macrobiotus dujardini).
OC   Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC   Hypsibioidea; Hypsibiidae; Hypsibius.
OX   NCBI_TaxID=232323 {ECO:0000313|EMBL:OQV13584.1};
RN   [1] {ECO:0000313|EMBL:OQV13584.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Z151 {ECO:0000313|EMBL:OQV13584.1};
RC   TISSUE=All body {ECO:0000313|EMBL:OQV13584.1};
RA   Yoshida Y., Koutsovoulos G., Laetsch D., Stevens L., Kumar S.,
RA   Horikawa D., Ishino K., Komine S., Tomita M., Blaxter M., Arakawa K.;
RT   "Comparative genomics of anhydrobiosis in the tardigrade Hypsibius
RT   dujardini.";
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OQV13584.1}.
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DR   EMBL; MTYJ01000121; OQV13584.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:OQV13584.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM    167    190       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    245    269       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      132    274       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      281    452       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION       69     91       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      543    564       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   564 AA;  63708 MW;  F8A1FB9F6E61EE28 CRC64;
     MIIVEWLLGG PRRIFMKTRR SIDAAPLGFS VTQRGNAVGE SASSATLALL DVEAGVSVHS
     GEPTTLSRRQ VNGYLSVPTP PGGSESDRSR STSPLYIGHN GFIFPHPAEG GLGGGSSSMM
     SQKAANAMMR FVSKTGDCNV RHSNVKRKGL KYLADIFTTL VDCQWRWCAL IFALGFFSTW
     LMYALLYFVF SWLHDDLNRA NLDSSEWTPC INKIHDFTSA YLYSVETQHT IGYGYRFANT
     ECPHVIITLC LQCLTGVALQ SILVGVLFAK LSRPKMRSET LMFSKEACIC KRDGRMHFMF
     RIGDMRRSHI VEAHIRVMCM KERVTEEGEE IPFYQYDMDV GFSDGTDRLF LVWPTIVTHE
     IDERSPLFNL SSEDLRMQRL EIIVILEGIV EATGLTTQAR TSYLPNEIRW GYRFEKVVRP
     YKDGSVRIDH DYFNKIYQVE STPRCSPKDL YQRQADDKVA ENVAKGLPPD TLIPAPPPKP
     QYRRRSYTPQ YMPQPHLQPE NVNITFESVM TPTTSQQIRR CSTPGPTARE EAASGAVIYQ
     DPLRCSPANP PAISMQPIEL PRIR
//
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