ID A0A1W1I1P2_9BACT Unreviewed; 882 AA.
AC A0A1W1I1P2;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:SLM46928.1};
GN ORFNames=NSJP_0756 {ECO:0000313|EMBL:SLM46928.1};
OS Nitrospira japonica.
OC Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC Nitrospira.
OX NCBI_TaxID=1325564 {ECO:0000313|EMBL:SLM46928.1, ECO:0000313|Proteomes:UP000192042};
RN [1] {ECO:0000313|EMBL:SLM46928.1, ECO:0000313|Proteomes:UP000192042}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Genome sequencing of Nitrospira japonica strain NJ11
RC {ECO:0000313|EMBL:SLM46928.1};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; LT828648; SLM46928.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W1I1P2; -.
DR STRING; 1325564.NSJP_0756; -.
DR KEGG; nja:NSJP_0756; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000192042; Chromosome i.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000192042}.
FT DOMAIN 711..727
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 824..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 637..644
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 882 AA; 97788 MW; 840529FEF9DAC856 CRC64;
MSDADVTPLM RQYHEIKRGY PEAILFFRVG DFYEMFGEDA KEASGLLSIA LTSRDKSSAA
PIPLCGVPHH AAQTYIAKLL KVGRTVALCE QVEDPRLAKG LVRREVVRLY TPGTLVDTEF
LPAGESSFLT AVSYAQQGGV KNGPVIGLAN LDVSTGEFWV TEFHGDQGTV ESALIDELVR
IEPKELLYAE SDRSLAPLLG RLDQTRLCAK PLAAFSAQEA TVLLTDHFGV HSLDGFGCAG
LTVGLAASGA VWRYFRETQP TASLSHVRRL QRRWHEESMH LDETTIRNLE LIRPLTGGDG
RLGSRHATVL SMLDRTSTSM GSRLLREWLT RPLLDRKAIQ SRLDAVGELT QYLSQRVALR
SVLRTVQDLA RLSSRIALGL AGPQECLALK NSLRALPELR SNLSVFTATL LADIRNSWDD
CRDIYETIER AIATDAPMSV RDGNVIREGF HPQVDALRKR KLEGKDWITA LESQERARTG
IDSLKVRFNQ VFGYYIEVTK ANLSKVPADF IRKQTLANAE RYMTPGLKDL EEQVTGAESQ
LYALEEELFI QVRERVAKDL PRLQSMAQAL SHLDVLAGLS ETAALHRYVQ PTIDEADEIR
IVEGRHPVVE QLSTDAPFVP NDTFLDGESH RVILLTGPNM AGKSTYLRQV ALIVLLAQIG
SFVPAAEAHI GLVDRIFTRV GASDNLAAGQ STFMVEMIES AQILNSATQK SLILLDEIGR
GTSTYDGLSI AWAIAEYIHD RRFLGARTLF ATHYHEMTQM ETLRDGIRNY RVAVQERNGD
VLFLRKIQPG GADKSYGIHV AKLAGLPDSV IIRAQEVLAK LEEPGSRTEG VHIREGRSDT
ARSDPQPHPL IEEVRQIDLF SLTPLDALNR LADLQKRATD SQ
//
