ID   A0A1W1W3A3_9BACT        Unreviewed;       608 AA.
AC   A0A1W1W3A3;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Penicillin-binding protein transpeptidase {ECO:0000313|EMBL:SMC00109.1};
GN   ORFNames=SAMN00120144_2524 {ECO:0000313|EMBL:SMC00109.1};
OS   Hymenobacter roseosalivarius DSM 11622.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC   Hymenobacter.
OX   NCBI_TaxID=645990 {ECO:0000313|EMBL:SMC00109.1, ECO:0000313|Proteomes:UP000192266};
RN   [1] {ECO:0000313|EMBL:SMC00109.1, ECO:0000313|Proteomes:UP000192266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11622 {ECO:0000313|EMBL:SMC00109.1,
RC   ECO:0000313|Proteomes:UP000192266};
RA   Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA   Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR   EMBL; FWWW01000098; SMC00109.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W1W3A3; -.
DR   STRING; 645990.SAMN00120144_2524; -.
DR   OrthoDB; 9766847at2; -.
DR   Proteomes; UP000192266; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192266};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..608
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012822735"
FT   DOMAIN          55..213
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          251..582
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   608 AA;  66831 MW;  EAA5F3A3947DEE5B CRC64;
     MRTAFTIWKT SLLATLLLLA ACSSPEKQSE APTKDPETSE VYTQRRVIVA DSLIRGRVLD
     RNGTVLVDTR PQYRLKLPRR PPLDTLALGQ LLGWDSVTIH RRIADALPYE EAPAGYPVQL
     SLTAAEAKRV RRDSSDWPKL TLTEGRQRAY TANAGAPVLG YMSAEAQAFF RQAKSYHRGR
     FYRLRSGGVE SYYNGLLHGH RGYLHPLVNK QGQTRGSWAT DTAFQQGQDL HLSIDGKLQA
     YAEKLMGNRK GYLVALDPRT GEILCYVSAP VYKPATITAP DQAGVRAKLL EHENMPLLNR
     PAMLANPPGS VFKLVNAAVA LQLGAISSTT SFGCDQSLLS CVHQHPQANS LTAGLKYSCN
     PYFYQVMRNL ISRVPDSLAQ DSTAARHLNL ALWRRYARSF GLDSVLGVDV SRESPGFLPT
     PAYYDKARRT SRWTYRSIYS LSIGQGEINL TGLQMANMAA IIANRGWYYT PHLVRCIGEG
     GPLPRFTEKH HTLIDSVHFA ALVPGMVAVM QRGGTAETSS LADVGITVAG KTGTVENDEG
     DDHAAFVGFA PAQNPKIAVA VYLENAGFGA TAAAPCAALV MEKYLRGNIA PRRKRWEARI
     QRRARNGY
//