ID   A0A1W1WW84_9NEIS        Unreviewed;       273 AA.
AC   A0A1W1WW84;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=bis(5'-nucleosyl)-tetraphosphatase (symmetrical) {ECO:0000256|ARBA:ARBA00012506};
DE            EC=3.6.1.41 {ECO:0000256|ARBA:ARBA00012506};
DE   AltName: Full=Ap4A hydrolase {ECO:0000256|ARBA:ARBA00032248};
DE   AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase {ECO:0000256|ARBA:ARBA00031248};
DE   AltName: Full=Diadenosine tetraphosphatase {ECO:0000256|ARBA:ARBA00033210};
GN   ORFNames=SAMN02745857_00032 {ECO:0000313|EMBL:SMC15867.1};
OS   Andreprevotia lacus DSM 23236.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales;
OC   Chitinibacteraceae; Andreprevotia.
OX   NCBI_TaxID=1121001 {ECO:0000313|EMBL:SMC15867.1, ECO:0000313|Proteomes:UP000192761};
RN   [1] {ECO:0000313|EMBL:SMC15867.1, ECO:0000313|Proteomes:UP000192761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23236 {ECO:0000313|EMBL:SMC15867.1,
RC   ECO:0000313|Proteomes:UP000192761};
RA   Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA   Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield
CC       ADP. {ECO:0000256|ARBA:ARBA00003413}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2
CC         H(+); Xref=Rhea:RHEA:24252, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58141, ChEBI:CHEBI:456216; EC=3.6.1.41;
CC         Evidence={ECO:0000256|ARBA:ARBA00001682};
CC   -!- SIMILARITY: Belongs to the Ap4A hydrolase family.
CC       {ECO:0000256|ARBA:ARBA00005419}.
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DR   EMBL; FWXD01000001; SMC15867.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W1WW84; -.
DR   STRING; 1121001.SAMN02745857_00032; -.
DR   OrthoDB; 9807890at2; -.
DR   Proteomes; UP000192761; Unassembled WGS sequence.
DR   GO; GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity; IEA:UniProtKB-EC.
DR   CDD; cd07422; MPP_ApaH; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004617; ApaH.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   NCBIfam; TIGR00668; apaH; 1.
DR   PANTHER; PTHR42850:SF11; BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [SYMMETRICAL]; 1.
DR   PANTHER; PTHR42850; METALLOPHOSPHOESTERASE; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192761}.
FT   DOMAIN          5..72
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
SQ   SEQUENCE   273 AA;  30202 MW;  6FF1C988015E7C76 CRC64;
     MARYAIGDLQ GCFVEFEQLL QRMEFDPLQD TLYLVGDLVN RGPASLPVLR WVMAQRHAVR
     MVLGNHDLHL LAVAAGLGKT KAGDTIDDVL QAPDCDAIID FLRQQPLMIS LGRTAIVHAG
     IWPGWSAAQA QALADEVSVA LCGPGWRDFL AAMYGNQPAL WQDDLQGVER LRFVVNAMTR
     MRFVNTDGSL QLKYKGELEK APAELYPWFD WPQRKQDARV VCGHWSALGL RQNGSLCALD
     TGCIWGGALT GIDLDSGRLY QVPAHRAYQA LAE
//