ID A0A1W1YEZ4_9FIRM Unreviewed; 688 AA.
AC A0A1W1YEZ4;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=HD domain-containing protein {ECO:0000259|PROSITE:PS51831};
GN ORFNames=SAMN06296952_0539 {ECO:0000313|EMBL:SMC34381.1};
OS Oscillospiraceae bacterium.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae.
OX NCBI_TaxID=2485925 {ECO:0000313|EMBL:SMC34381.1, ECO:0000313|Proteomes:UP000192633};
RN [1] {ECO:0000313|Proteomes:UP000192633}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KHP2 {ECO:0000313|Proteomes:UP000192633};
RA Varghese N., Submissions S.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FWXP01000001; SMC34381.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W1YEZ4; -.
DR OrthoDB; 9806952at2; -.
DR Proteomes; UP000192633; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR011624; Metal-dep_PHydrolase_7TM_extra.
DR NCBIfam; TIGR00277; HDIG; 1.
DR PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR Pfam; PF07697; 7TMR-HDED; 1.
DR Pfam; PF01966; HD; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 479..626
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
SQ SEQUENCE 688 AA; 76525 MW; 87B80C3BBAD7D9B3 CRC64;
MKKGFGLRFQ QLMTLILTTV IIILIVFYGY RPVSYNLSVG SVCSTDIYAP RSFVDTYQTE
YNALVAKNTV NPVEIRSETE SEDNVTRIQN FFTLVRQTRE LRIDENGVPI ENFDQEFESL
KVNLEELLGN VPSDNDLHTF ISMSSSAFNL IEDRSISITE LIMMDNVSNS ASLNDAIDAH
IDSFSEANPS YASYASTMKN VLVLLLSPNS VYDEVATQEA AENAYLTALN ESVMVDKGTK
IISAGEVIND HSYQILVDLE LIRSESFDAV ILVRIAVYEL VLAVVMLIYI ATVHKNDFSD
MRITYALVVT FIIPIGASVY LTDMSTLLIV TLFFATICAS YIGIAAGIML SLIEMLMMWP
LYSFDSEFVF VNVIGILICA IWSGNKKRMY NSAAQIILPA AFCVLSAVCY NWLLGSTVNV
FIESCVWIGV SAAFSIIIAI GLMPIYDLVS NAVSPVRLIE LSQPGHPLLK RLFMEASGTY
HHSMMVANLA DSAAEAIGAD ALLCKVAAYY HDIGKLENPK FFTENQAEGV NPHDDKTTEE
SVAIITKHTE DGVKLARKHR LPDPIVRIID EHHGTTYPAY FYNKAVKQAE EQGLPAPDVN
AFRYKGHIPA TRESAILMIA DTCEAAVRSS KLEDPDSIEA LIRKLIKSKI DQDQLISSGL
SFDDIEKMIE AFMHVYAGVF HERIQYPE
//
