ID   A0A1W1YTL4_9FIRM        Unreviewed;       665 AA.
AC   A0A1W1YTL4;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Heterodisulfide reductase subunit A {ECO:0000313|EMBL:SMC39555.1};
GN   ORFNames=SAMN06296952_0966 {ECO:0000313|EMBL:SMC39555.1};
OS   Oscillospiraceae bacterium.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae.
OX   NCBI_TaxID=2485925 {ECO:0000313|EMBL:SMC39555.1, ECO:0000313|Proteomes:UP000192633};
RN   [1] {ECO:0000313|Proteomes:UP000192633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KHP2 {ECO:0000313|Proteomes:UP000192633};
RA   Varghese N., Submissions S.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the HdrA family.
CC       {ECO:0000256|ARBA:ARBA00006561}.
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DR   EMBL; FWXP01000002; SMC39555.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W1YTL4; -.
DR   OrthoDB; 9758544at2; -.
DR   Proteomes; UP000192633; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.20; -; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR039650; HdrA-like.
DR   PANTHER; PTHR43498:SF1; COB--COM HETERODISULFIDE REDUCTASE IRON-SULFUR SUBUNIT A; 1.
DR   PANTHER; PTHR43498; FERREDOXIN:COB-COM HETERODISULFIDE REDUCTASE SUBUNIT A; 1.
DR   Pfam; PF12838; Fer4_7; 1.
DR   Pfam; PF13450; NAD_binding_8; 1.
DR   SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 3.
DR   PROSITE; PS51379; 4FE4S_FER_2; 4.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          234..264
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          285..319
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          581..610
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          622..651
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
SQ   SEQUENCE   665 AA;  72436 MW;  EE9437FEB0A40EB5 CRC64;
     MQRIGVFVCH CGTNIAATVD VKKVVELVRF EPGVVFADDY MYMCSEAGQE KIIAAIKEHD
     LTGLVICSCS PRMHEKTFRA CAEKAGLNPY MVEVANIREQ CSWIHKDREE ATEKAVILAR
     AAIAKVNLNT PLQEGESPVT KRALIIGGGI AGIQTALDIA DAGYEVDIVE REPSIGGRMS
     QFDKTFPTLD CASCILTPKM VEVNQHPNIT LYTYSEVEGV SGYVGNFDVK IRKKARSVDM
     SACTGCGECQ AKCPLGKMGK IPSEFDRGLR TRPAIYMPFA QAVPAVPVID RENCTYFKTG
     KCGVCAKICP SKAVNYEQED EIVTVKYGAI VVATGFDIIN LDKFGEYAYN ESPDVITSIE
     LERLMNASGP TGGHLERMSD HKQPKDIVFI QCVGSRCDDE KGKPYCSKVC CMYTAKHAML
     IKDHWPDTNI TVFYIDVRTP GKNFDEFYRR AVEQYHVNYV KGQVGKVIPQ PDGSLLVQGV
     DLLDNKQIMK KTDMVVLAAA VEPNKGVRKI ATMLTASIDN NDFLTEAHAK LRPVESPTAG
     IFLSGMAQGP KDIPETVSQA GAAAVKVVGL LAKDKLKTNP CTAKCDPMFC NGCSTCANVC
     PYGAITYEDQ QVRGPGVNET RRVAVVNNAL CQGCGACTSA CPSGAMDLQG FSNRQITTEV
     DSICR
//