ID   A0A1W1ZMQ9_9FIRM        Unreviewed;       900 AA.
AC   A0A1W1ZMQ9;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Aldehyde-alcohol dehydrogenase {ECO:0000256|PIRNR:PIRNR000111};
GN   ORFNames=SAMN06297397_1073 {ECO:0000313|EMBL:SMC49674.1};
OS   Clostridiales bacterium.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales.
OX   NCBI_TaxID=1898207 {ECO:0000313|EMBL:SMC49674.1, ECO:0000313|Proteomes:UP000192328};
RN   [1] {ECO:0000313|Proteomes:UP000192328}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WTE2008 {ECO:0000313|Proteomes:UP000192328};
RA   Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA   Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the iron-containing
CC       alcohol dehydrogenase family. {ECO:0000256|ARBA:ARBA00035645,
CC       ECO:0000256|PIRNR:PIRNR000111}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the aldehyde
CC       dehydrogenase family. {ECO:0000256|ARBA:ARBA00035641,
CC       ECO:0000256|PIRNR:PIRNR000111}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:SMC49674.1}.
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DR   EMBL; FWXZ01000002; SMC49674.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W1ZMQ9; -.
DR   OrthoDB; 9804734at2; -.
DR   Proteomes; UP000192328; Unassembled WGS sequence.
DR   GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:1990362; F:butanol dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR   GO; GO:0015976; P:carbon utilization; IEA:InterPro.
DR   CDD; cd08178; AAD_C; 1.
DR   CDD; cd07122; ALDH_F20_ACDH; 1.
DR   Gene3D; 3.40.50.1970; -; 1.
DR   Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR   InterPro; IPR034789; AAD_C.
DR   InterPro; IPR001670; ADH_Fe/GldA.
DR   InterPro; IPR018211; ADH_Fe_CS.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR044731; BDH-like.
DR   InterPro; IPR012079; Bifunc_Ald-ADH.
DR   PANTHER; PTHR43633; ALCOHOL DEHYDROGENASE YQHD; 1.
DR   PANTHER; PTHR43633:SF1; ALCOHOL DEHYDROGENASE YQHD; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   Pfam; PF00465; Fe-ADH; 1.
DR   PIRSF; PIRSF000111; ALDH_ADH; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR   PROSITE; PS00913; ADH_IRON_1; 1.
DR   PROSITE; PS00060; ADH_IRON_2; 1.
PE   3: Inferred from homology;
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|PIRNR:PIRNR000111}.
FT   DOMAIN          11..404
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   DOMAIN          461..853
FT                   /note="Alcohol dehydrogenase iron-type/glycerol
FT                   dehydrogenase GldA"
FT                   /evidence="ECO:0000259|Pfam:PF00465"
SQ   SEQUENCE   900 AA;  98108 MW;  8856789BB2E52103 CRC64;
     MDHKPYETTD SPETLEAAIA RVREAQRLYA SYTQEQVDKI FLAAATAANQ ARIPLAKLAV
     EETGMGVVED KVIKNHYASE YIYNAYRDTK TCGVIEEDKA GGMKKIAEPI GVVAAVIPTT
     NPTSTAIFKS LICLKTRNGI IISPHPRAKK ATIEAAKVVL EAAVKAGAPE GIIAWIDVPS
     LEMTNTLMKE ADIILATGGP GMVKAAYSSG KPALGVGAGN VPAVIDESAD ILLAVNSIIH
     SKTFDNGMIC ASEQSVIVAD SIYDSVKAEF ASRGCWFLKG NDLDRVRKTI LINGALNAKI
     VGQSAYNIAK LAGVTVPEGT KVLIGEVESV EITEEFAHEK LSPVLAMYRA ADLEDAFAKA
     EKLIADGGYG HTASLYINTQ KKQEVLDAFA ARMKTCRIVV NEPSSQGGIG DLYNFRLTPS
     LTLGCGSWGG NSVSENVGVK HLLNIKTVTE RRENMLWFRT PEKIYIKKGC LPVALGELKS
     VMGKKKAFVV TDSFLYHNGN TKPITDKLDE MGIRHATFFD VAPDPTLACA KAGAEQMRLF
     EPDVIIALGG GSAMDAAKIM WVLYEHPEVD FMDMAMRFMD IRKRVYTFPK MGEKAYFVAV
     PTSAGTGSEV TPFAVITDER SGVKYPLADY ELLPDMAIID TDFHMTAPKS LTAASGIDAV
     THALEAYASM LATDYTDGLA IRALQNIFAY LPRAYDDGLT DVEAREKMAN AATMAGMAFA
     NAFLGVCHSM AHKLGAFHHI AHGVANALMI EEVIRFNAAE TPAKMGTFPQ YDHPRTLRRY
     AEVAEALGIT EGTDSEKLET LIRKINDLKA YVGIKPTIRD YVPDEKDFLD RLDAMTEQAF
     DDQCTGANPR YPLMSEIRQM YLNAYYGGKH FTETAKPTEY DIATYEDDPA KKAYRPGHKQ
//