ID A0A1W2A5Q0_9FIRM Unreviewed; 640 AA.
AC A0A1W2A5Q0;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=SAMN02745168_1525 {ECO:0000313|EMBL:SMC55980.1};
OS Papillibacter cinnamivorans DSM 12816.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Papillibacter.
OX NCBI_TaxID=1122930 {ECO:0000313|EMBL:SMC55980.1, ECO:0000313|Proteomes:UP000192790};
RN [1] {ECO:0000313|EMBL:SMC55980.1, ECO:0000313|Proteomes:UP000192790}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12816 {ECO:0000313|EMBL:SMC55980.1,
RC ECO:0000313|Proteomes:UP000192790};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; FWXW01000003; SMC55980.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W2A5Q0; -.
DR STRING; 1122930.SAMN02745168_1525; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000192790; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000192790}.
FT DOMAIN 209..327
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 457..597
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 340..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 640 AA; 68241 MW; 6153538BAD665B67 CRC64;
MPRILQLDSH VADLIAAGEV VERPGSVVKE LLDNAIDAGA SAVTVEIRSG GMSYIRVSDN
GCGIPSEDVE TAFLRHATSK IRDESDLAAI GTLGFRGEAL AAVAAVSRVE LLTCSSEEEM
GTALSLEAGV PGEREPAGCP RGTTLVVRNL FYNTPARLKF MKKDSAEAAN VAAVVQNAAL
SHPEVSFKFI RDGKEEMLTP GDGKLLSAIY GALGREFALG LMEVSSSGAD ARVWGYVTKP
LSGHGTRGYQ HFFVNGRYVK SRLMTAALEE AYKNRAMTGK FPGCVLHLRL HPGAVDVNVH
PAKTEVKFLS ERRVFDAVYY AVLSALEGEL SHPEMALRAQ DGARRTDTPE HGGFPAGPEV
RVGPPSAASG FQTSVFPADT ELKDGGLALE SGRFLTYGVP SASVRLPYRE TDSSITAPSV
SPGSVSVQSA LAPDREERQQ PHESAPLPPE SPGLFRILGE ALETYIVVEK PGGLLLIDKH
AAHERILFDR LVKEPGSVMA QVLLSPAVVA LPKEESAVLL ENRGMLSEFG FEVEDFGGGS
LIVRQTPWDI DPGGIPSALS ELAGCILDAK RVDPKSVRGE VLSSIACKAA VKAGSKSSPE
EMTALVEEVM AGRVRYCPHG RPVAISLSRA QLEKQFGRIQ
//
