ID   A0A1W2AI95_9FIRM        Unreviewed;       409 AA.
AC   A0A1W2AI95;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=2-isopropylmalate synthase {ECO:0000313|EMBL:SMC60425.1};
GN   ORFNames=SAMN02745168_1748 {ECO:0000313|EMBL:SMC60425.1};
OS   Papillibacter cinnamivorans DSM 12816.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Papillibacter.
OX   NCBI_TaxID=1122930 {ECO:0000313|EMBL:SMC60425.1, ECO:0000313|Proteomes:UP000192790};
RN   [1] {ECO:0000313|EMBL:SMC60425.1, ECO:0000313|Proteomes:UP000192790}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 12816 {ECO:0000313|EMBL:SMC60425.1,
RC   ECO:0000313|Proteomes:UP000192790};
RA   Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA   Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FWXW01000004; SMC60425.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W2AI95; -.
DR   STRING; 1122930.SAMN02745168_1748; -.
DR   OrthoDB; 9804858at2; -.
DR   Proteomes; UP000192790; Unassembled WGS sequence.
DR   GO; GO:0046912; F:acyltransferase activity, acyl groups converted into alkyl on transfer; IEA:InterPro.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   Gene3D; 1.10.238.260; -; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR002034; AIPM/Hcit_synth_CS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000891; PYR_CT.
DR   PANTHER; PTHR42880; HOMOCITRATE SYNTHASE; 1.
DR   PANTHER; PTHR42880:SF1; ISOPROPYLMALATE_HOMOCITRATE_CITRAMALATE SYNTHASE FAMILY PROTEIN; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS00816; AIPM_HOMOCIT_SYNTH_2; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000192790};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          29..283
FT                   /note="Pyruvate carboxyltransferase"
FT                   /evidence="ECO:0000259|PROSITE:PS50991"
SQ   SEQUENCE   409 AA;  44982 MW;  245EEC1556692C4F CRC64;
     MSCKTNEYWV TEFNYLDEVT ETLDIPERVE IYDVTLREGN QTPGCIMRKE EQFALAKDLD
     DLGVNFLEFF PAVSKDDEEV VTELMKTGVL KHAKVSALVR PRTIDLDLAA KCGAKHIFLE
     GPSHLASAGL MGYASESELI QSFVDTAKRA REYGMGITSC PWDCGKANLP LLERWVKELA
     AAGVEDIAYG DTFGYTMPWT TIAMVRKYRQ WAGPDVTISC HFHNDYGMAT AGTLAAVAGG
     ATRVQVAMNN LGERAGNAAL DEVAVNLALN MGVKTDINLK KLYPVSKRIE AITKIPVGRK
     KPILGDETFV MGSGIVVDML LQLAEKHAEY GMMPFDPALV GQPPYRIVYG KGAGTNMVSD
     LLRRMGISAT KEQVQKITVA IKEEALLTKS LLSEFRVREL IGDILAETK
//