ID   A0A1W2ARW5_9FIRM        Unreviewed;       577 AA.
AC   A0A1W2ARW5;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Molybdopterin or thiamine biosynthesis adenylyltransferase {ECO:0000313|EMBL:SMC63262.1};
GN   ORFNames=SAMN02745168_1906 {ECO:0000313|EMBL:SMC63262.1};
OS   Papillibacter cinnamivorans DSM 12816.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Papillibacter.
OX   NCBI_TaxID=1122930 {ECO:0000313|EMBL:SMC63262.1, ECO:0000313|Proteomes:UP000192790};
RN   [1] {ECO:0000313|EMBL:SMC63262.1, ECO:0000313|Proteomes:UP000192790}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 12816 {ECO:0000313|EMBL:SMC63262.1,
RC   ECO:0000313|Proteomes:UP000192790};
RA   Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA   Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FWXW01000004; SMC63262.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W2ARW5; -.
DR   STRING; 1122930.SAMN02745168_1906; -.
DR   OrthoDB; 4088010at2; -.
DR   Proteomes; UP000192790; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   CDD; cd01483; E1_enzyme_family; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR032701; Prok-E2_B_dom.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   PANTHER; PTHR10953:SF102; ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3; 1.
DR   PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR   Pfam; PF14461; Prok-E2_B; 1.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotidyltransferase {ECO:0000313|EMBL:SMC63262.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192790};
KW   Transferase {ECO:0000313|EMBL:SMC63262.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        247..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          45..133
FT                   /note="Prokaryotic E2 family B"
FT                   /evidence="ECO:0000259|Pfam:PF14461"
FT   DOMAIN          306..533
FT                   /note="THIF-type NAD/FAD binding fold"
FT                   /evidence="ECO:0000259|Pfam:PF00899"
SQ   SEQUENCE   577 AA;  64471 MW;  F503D0ECCB001121 CRC64;
     MVDLEKVIRD VNIKQGLSFQ PSSHPTEDGN SYVACYSGHY LSYGEITIAF EASFPYALPD
     IFIKNTSKPH VHVTPAGKIC LTDESALLLD INRPEQLVID CLDRVAQILS ILPGTDLYQE
     ELKKEFLSYW GIYTPGIIYF SILQIPKKEG FIQEFPLFKY GKSLLLANST DDANRYICET
     LGLDSTAAVD SPEEYALVIG LKQGCAFPSP FKQHNWFSVM HYIRDNTDAQ ISHEFFKLMN
     ARVKNKIINI IFISPGADGN ILFGVVVGFS NRRKTPMKSS IKTSVMQINL LREDRDYLLA
     RGGSALSLTD KRVLLLGCGS VGGYLANNLC QMGITQIDLL DKDTFKSENV YRHFMGYDAL
     RRPSSKSKAD LLRGVLSDKY PDVDIDSMNY QDRSVEAVIL SNPERLSQYD LVISALGEPT
     INLAINKALV ENNIPTPFIV CFNEPYGIGG HVITTNLSQK SCLRCYYSDF LEGTLRPFRG
     SLVAPNQNFK KSLSGCSSTF VPYSALDSQQ TAIHAAHKAV DILTGKLNRN NFFTWRGDSS
     LLLSQGYEVS DFYNSENPSD EITNPKCPVC QRRHSVS
//