ID A0A1W2B870_9SPHN Unreviewed; 338 AA.
AC A0A1W2B870;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=SAMN06272759_105360 {ECO:0000313|EMBL:SMC68578.1};
OS Novosphingobium sp. B1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1938756 {ECO:0000313|EMBL:SMC68578.1, ECO:0000313|Proteomes:UP000192500};
RN [1] {ECO:0000313|Proteomes:UP000192500}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B1 {ECO:0000313|Proteomes:UP000192500};
RA Varghese N., Submissions S.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
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DR EMBL; FWXL01000005; SMC68578.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W2B870; -.
DR STRING; 1938756.SAMN06272759_105360; -.
DR OrthoDB; 9778962at2; -.
DR Proteomes; UP000192500; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SMC68578.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 26..74
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 86..293
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 338 AA; 37897 MW; 7260F8AA810EA12B CRC64;
MTSKAAKLVH VDDSLPGVTR RRCGRGWAYF DAKGQRVTDR EEISRLNAIA LPPAYVDTWF
CPAANGHILA TGIDAKGRKQ YRYHPDFRAE REGEKFDRCA AFGRLLPLVR ARVEDELSSR
GLSRDRCIAS VVRLLDTGGI RVGNEAYARS NDSFGATTLR MKHAQVKGQV LRLRFRAKSG
KDREMRITDR SLVRFVKKMQ DLPGQNLFQY ITYDGTPCAI GSADVNDWLR EVMGEDFTAK
HFRTWRASVL GFEALANAQG KVQLKELLTQ VSDHLGNTPA IARKSYVHPA VMALVDEQET
WRAGLRLPRA TRWLSREERG LITLLEEGPA AAELLAAG
//
