ID A0A1W2C870_9BURK Unreviewed; 298 AA.
AC A0A1W2C870;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:SMC81389.1};
GN ORFNames=SAMN06296008_12022 {ECO:0000313|EMBL:SMC81389.1};
OS Polynucleobacter kasalickyi.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Polynucleobacter.
OX NCBI_TaxID=1938817 {ECO:0000313|EMBL:SMC81389.1, ECO:0000313|Proteomes:UP000192708};
RN [1] {ECO:0000313|EMBL:SMC81389.1, ECO:0000313|Proteomes:UP000192708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VK13 {ECO:0000313|EMBL:SMC81389.1,
RC ECO:0000313|Proteomes:UP000192708};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FWXJ01000020; SMC81389.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W2C870; -.
DR STRING; 1938817.SAMN06296008_12022; -.
DR OrthoDB; 9777604at2; -.
DR Proteomes; UP000192708; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000192708}.
FT DOMAIN 2..161
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 166..288
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 170
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 298 AA; 31934 MW; B0AE434D280F0D5D CRC64;
MKILFIGVGK MGLPMSCHLL NQGHDIRVLD PDPIRLQEAA IKGLEVASQA NDSVEDFIWA
DYIFSSLPND HAFLEVANQV AQKAAKNTKY IDTSTISISA SAKAAEILEN AGVQYLRVAV
SGNNHMAAAA NLTILASGPK PVYDEALPLL SSWGSSQFYL GDKEQARLMK LVVNLLIAQT
SAMLAEGLTL GRLGNLDWQD MWQVLSASAV GSPILKAKSA QLGLPLGERD FSPTFTVHQM
IKDLQLITSA GDDLGASLAQ TKTTLGWMNQ AIAQGDGGLD YAAIIRVLER QVGITDLS
//
