ID A0A1W2CKG1_9PSEU Unreviewed; 2499 AA.
AC A0A1W2CKG1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Non-ribosomal peptide synthase domain TIGR01720/amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SMC85680.1};
GN ORFNames=SAMN05660733_02147 {ECO:0000313|EMBL:SMC85680.1};
OS Lentzea albidocapillata.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Lentzea.
OX NCBI_TaxID=40571 {ECO:0000313|EMBL:SMC85680.1, ECO:0000313|Proteomes:UP000192840};
RN [1] {ECO:0000313|Proteomes:UP000192840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44073 {ECO:0000313|Proteomes:UP000192840};
RA Varghese N., Submissions S.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; FWYC01000005; SMC85680.1; -; Genomic_DNA.
DR RefSeq; WP_051768842.1; NZ_JOEA01000003.1.
DR STRING; 40571.SAMN05660733_02147; -.
DR eggNOG; COG1020; Bacteria.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000192840; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd17652; A_NRPS_CmdD_like; 1.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 466..537
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1042..1116
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2411..2486
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 449..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2499 AA; 273307 MW; DBA16D67BC70A338 CRC64;
MFLTALFRAR VASSPHAPAV IAPSGTLTYA ELDVRTNRLA WWLRERGAGP ERVVALRMPR
SAEIVVAQLA VLKAGAAYLP VDPAYPAERI DFMLRDAAPL LTLESAVDTS GMRDVDPEAE
VDPAHPAYVI YTSGSTGRPK GVVVTHAGLA NFASAEIEHF QVRPGDRVLQ FSSPSFDASV
LELCMALPSG AALVVPPEGP LLGEQLAEVL RDNRITHALI PPVAMATVPE VPLPDFRTLI
VGGDACTPEL VERWSPGRRM INAYGPTEST VVSTWSEPLS PGGSPPIGTP IPGTVAHVLD
DDLRPAAEGE LYVTGTGLAR GYLDRPGLTA QRFVANPFGP GRLYRTGDVV RWRDGVLEFV
GRADHQVKIR GFRIEPGEIE AVLRDHPGVR EAVVVARSDQ GLKRLVAYVT GEAERTDLRA
LVASRLPEHM VPSAFVVLDA FPMSPNGKLD RSALAEPSGG AETATAPRTP AEHRVAQVWA
EVLGLDAAGP EDDFFQLGGD SVLAMRTLTL LGGGLPLRAL FEHRTVAALA AVLPDDRPAE
IRPTHTGQPV PLSRTQKRLQ GAEGPDSNTA VGVRLTGSLD LTRLQHALDL LVARHDALRT
TVHGHVQVIS PHGAVRLELA DDLEAELAKP FDLRTGPLTR ALLTRDQVLV LCQHHIITDG
RSVTVLLDEL ARLYEGEQLP RPRLQYPDFA LWQQEQPVPS VDYWRHKLDG LEPLDLRTDR
VRPPLRSTAG AVLRRRLGAG LVQRLTTLGR AHDATLFMTL TALVKVIMAR HSGQRDIAVG
TVNAGRDRAE LDGVSGFFVN TLVLRTWLDP RQPFTAYLDQ VRDTVLEAFA HDDVPFDQLV
EQLRPDRDPS RTPLVQAVVA LQQPLLTRTA FGDLAAEEVD LPRPAARFDL VTEFWPAQNR
GEGDDLTLTL EYNTDLFDAS TIERMADDLV ALCEAVTANP DHDLVEFAGE AEDVARVRGF
RVDPAVVEKV LRRMVDDAHV VMHDERLVGY VTRANPAELK GVLSQVLPDY LIPSAWVVLD
EIDRANLPEP PAPRIERARF VAPRTPVEAV LASVFAEVLG VGQVGVRDGF LELGGDSILA
IGVVTKARAA GLHLSARDVF QHQTIAELAP RVRSSSRASA EQGTVTGDVP LTPIQRWFFD
HHDGLSRFHQ SVVLDFAEDV DAERLARAVS TVVAHHDALR TRYTFDDGWR QRIEPSGHSQ
LETEIVAPRQ VRLSAHHLVV DGISWRIIAE DLRAAYRGEP LPPKTTSLRE WAHQLAGHAR
TGGFDDERTH WEQLTGGSSK TGTTASQRGV TVRLSGQDTR RVLREVPPVY RTQVNDVLLT
ALGCVLSGWT GSRRVLVALE GHGREELFDG VDLSRTVGWF TSMFPVALDV PEAGWGETLK
AVKEQLRAVP RRGIGYGALR YLTGDGLPDV TPEVGFNHLG RFDDDQRGMD LDADPDAPRP
HAIDVVSRVE GDQLEVTWFY STELHDEATI TRLADEMLVA LRDIAHHCAQ PDAGGRTPSD
FPLARLDQAS CDRIALPHVE DVYPLTPMQA GMVFHSLDGV YVQQTSFVVT ADPDELAAAW
QRAVDRTPVL RSSVVWEGVP EPVQVVHAQA PVPIRHLDWT RGDREELLRA LLESDRVEGM
DLATAPLMRL TLARLPEDEV QVLWTFHHVL LDGWSVFQVL TDVLGEPAER PPFRDYVEWL
HHQDDEPAER HWREVLGDFT EPTPLPFDRT PSGQHGSSTT ANLRISLSAE ESAALYAFAR
EQRLTPGSVV QGAWAVLLAR YGGRDDVCFG ATVSGRPADL PGVDDITGIF INTLPVRVAV
DDRAPVAAWL RGLQETQVEA RRFEHVPLTD LRAWSGVEGG VNLFDSVLVF ENYPAQGLPL
RDLRAVETTN FPLSATVYPD TELTVLLGYD PAAFDETTAR RLGGHLRVLL TGIAENADRQ
VGALPLLTAD ERQRVLVEWN DTAHEVPDRT LLDLLAPHGE EAVRFEGEAI SGAELERRAN
RLAHRLIAEG AGPERVVAVS LPRSFDLVVT LLAVLKAGAA YLPIDAGLPA ERVAFMTDDA
GPVLVIDSPL DASGYPSTAP ETALTQDHPA YVIYTSGSTG RPKAVVVPHR GVVNRLLWTQ
HEYGLTPDDR VLQKTPASFD VSVWEFFWPL IAGATLVVAK PEGHRDPAYL ADLVQRESIT
TVHFVPSMLR AFLREPAAKG CTGLRRVLCS GEALPPDLVR AWYETIDVPL HNLYGPTEAS
VDVTSWATCP GADVVPIGRP VWNTALRVLD AELRPVPPGV PGELYLAGAQ LARGYLNRPG
LTAGRFVADP FGRAGTRMYR TGDLARWRPD GSVEYLGRTD HQVKIRGLRV ELGEIEAVLG
DAVVVVRDER IVAYVTTPDV DALRKAAEAA LPDYMVPSAI VRLDEFPLSP NGKIDRRALP
DPEWTPVEHV PPRTPAEEAV ASIWAQALGV GRIGAEDDFF ALGGDSIRGM HVTSLLRDAF
GVELSPRDVL SARTVAALAD LVEELILREL EHTASLNEL
//
